Advances in Porcine Virus: From Pathogenesis to Control Strategies

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Veterinary Microbiology".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 450

Special Issue Editor


E-Mail Website
Guest Editor
Institute of Virology, Free University Berlin, Berlin, Germany
Interests: molecular virology; porcine reproductive and respiratory syndrome virus (PRRSV); equine arteritis virus (EAV); viral protein processing and modification (glycosylation and acylation); cell tropism and cellular receptor; pathogenesis; antivirals

Special Issue Information

Dear Colleagues,

Swine viruses are considered to be the main pathogens affecting pigs and can cause significant economic losses in the swine industry. The prevention and control of disease-causing viruses is typically more difficult than other causes due to the high frequency of mutations and recombination between strains. In addition, numerous viruses have emerged or re-emerged in pigs in recent years. Some cause severe clinical symptoms in pigs, such as African swine fever virus (ASFV), new variant strains of porcine epidemic diarrhea virus (PEDV), and porcine reproductive and respiratory syndrome virus (PRRSV). Some of the emerging swine viruses have potentially zoonotic potential, for example, swine enteric alphacoronavirus (SeACoV). It made the situation even worse. Research is essential and urgently needed to investigate the mechanisms underlying the pathogenesis of these viruses and to elucidate the virus replication strategy, immune escape mechanism, etc. This knowledge has paved the way for the development of novel diagnostic tools and preventative measures for the early detection and containment of viral outbreaks. The aim of this Special Issue is therefore to provide experts with a platform to exchange research advances related to the mechanisms of replication, pathogenesis and control of swine viruses.

As Guest Editors of this Special Issue, manuscripts containing research articles, review articles, and short communications on the above topics are welcome.

Dr. Minze Zhang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pathogenesis
  • porcine viruses
  • African swine fever virus
  • zoonotic potential
  • antivirals
  • porcine reproductive and respiratory syndrome virus

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

13 pages, 5013 KiB  
Article
Porcine Epidemic Diarrhea Virus Is Inhibited by GS-441524 During an In Vitro Infection
by Shijuan Dong, Rujing Sun, Bingqing Chen, Fusheng Si, Chunhua Li, Daojing Zhang, Ruisong Yu and Huili Liu
Microorganisms 2025, 13(5), 1089; https://doi.org/10.3390/microorganisms13051089 - 8 May 2025
Abstract
Porcine epidemic diarrhea virus (PEDV), the etiology of porcine epidemic diarrhea (PED), continues to impose severe economic burdens on pig farms in China. The continuous emergence of new variant strains makes it difficult for vaccinated sows to provide protective immunity to piglets. Hence, [...] Read more.
Porcine epidemic diarrhea virus (PEDV), the etiology of porcine epidemic diarrhea (PED), continues to impose severe economic burdens on pig farms in China. The continuous emergence of new variant strains makes it difficult for vaccinated sows to provide protective immunity to piglets. Hence, there is an urgent need for efficacious therapeutic drugs in clinical practice. In the present study, the antiviral activity of GS-441524, a nucleoside analogue, against PEDV was evaluated. It can efficiently inhibit the proliferation of trypsin-dependent and trypsin-independent PEDVs in a dose-dependent manner, exhibiting greater efficacy against the trypsin-independent strain. GS-441524 can inhibit trypsin-independent PEDV proliferation in Vero cells with EC50 and CC50 values of 2.6 μM and 104.4 μM, respectively. As expected, GS-441524 exerts its inhibitory effect during the replication phase of the four stages of the PEDV proliferation cycle. Even at a high viral infection dose of MOI 0.5 or added 6 h post-viral infection, 20 μM GS-441524 can still effectively inhibit PEDV proliferation. These findings emphasize the potent antiviral activity of GS-441524 against PEDV, and its therapeutic efficacy on PEDV-infected piglets warrants further investigation. Full article
(This article belongs to the Special Issue Advances in Porcine Virus: From Pathogenesis to Control Strategies)
Show Figures

Figure 1

Back to TopTop