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Microorganisms
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Advances in Microcystis aeruginosa
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Advances in Microcystis aeruginosa

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Environmental Microbiology".

Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 9806

Special Issue Editors

Prof. Dr. Leda Giannuzzi

E-Mail Website
Guest Editor
Area of Toxicology, School of Exact Sciences, National University of La Plata (UNLP), La Plata 1900, Buenos Aires, Argentina
Interests: Microcystis aeruginosa; microcystins; cyanobacteria bloom
Dr. Marcelo Pablo Hernando

E-Mail Website
Co-Guest Editor
Department of Radiobiology, National Atomic Energy Commission, San Martin, Province Buenos Aires, Argentina
Interests: microalgal; microcystis aeruginosa; harmful algal blooms

Special Issue Information

Dear Colleagues,

Microcystis aeruginosa is a species of freshwater cyanobacterium that can form harmful algal blooms of economic and ecological importance. It is one of the most frequently studied cyanobacteria due to its worldwide distribution. A strong impact on important ecosystem services such as recreation and fishing, aquaculture, irrigation and drinking water treatment has been indicated in the literature. Many strains of Microcystis produce various hepatotoxins called microcystins. Management strategies, including chemical and biological controls, are important tools that can prevent or mitigate the proliferation of toxic M. aeruginosa blooms.

Research on M. aeruginosa and microcystins across diverse fields is rapidly expanding, due to their impact on human health and on the biota. However, despite being one of the most studied cyanobacteria, there are still gaps in the knowledge that require more in-depth study.

This Special Issue covers subjects related to the adaptive strategies of M. aeruginosa in a scenario of global change, and the ecological role of its distribution in bodies of water. Another topic of interest is the potential mutualist interaction between Microcystis and their microbiome of associated bacteria. In addition, the function of microcystins production, changes in gene expression due to biotic and abiotic factors, and the release and degradation of microcystin are topics of importance. Studies on the removal and control of M. aeruginosa and microcystins in the environment and water treatment plants are welcome, as well as toxicological studies of microcystins in human and animal models.

We invite the submission of original research findings, case reports, or review articles for this Special Issue, which focuses on various aspects of M. aeruginosa and its toxins.

Prof. Dr. Leda Giannuzzi
Dr. Marcelo Pablo Hernando
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Microcystis aeruginosa
  • microcystins
  • physiological characteristic
  • cyanobacteria bloom
  • watershed management
  • drinking water treatment
  • metabolome
  • HRMS (UPLC-QTOF)
  • human and animal toxicity

Published Papers (5 papers)

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Editorial

Jump to: Research, Review

4 pages, 209 KiB  
Editorial
The Eco-Physiological Role of Microcystis aeruginosa in a Changing World
by Leda Giannuzzi and Marcelo Hernando
Microorganisms 2022, 10(4), 685; https://doi.org/10.3390/microorganisms10040685 - 23 Mar 2022
Cited by 2 | Viewed by 1474
Abstract
Among the bloom-forming cyanobacteria, Microcystis aeruginosa is one of the most harmful species [...] Full article
(This article belongs to the Special Issue Advances in Microcystis aeruginosa)

Research

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18 pages, 5848 KiB  
Article
In Silico Analysis of a GH3 β-Glucosidase from Microcystis aeruginosa CACIAM 03
by Gustavo Marques Serra, Andrei Santos Siqueira, Fábio Alberto de Molfetta, Agenor Valadares Santos and Luciana Pereira Xavier
Microorganisms 2023, 11(4), 998; https://doi.org/10.3390/microorganisms11040998 - 11 Apr 2023
Viewed by 1726
Abstract
Cyanobacteria are rich sources of secondary metabolites and have the potential to be excellent industrial enzyme producers. β-glucosidases are extensively employed in processing biomass degradation as they mediate the most crucial step of bioconversion of cellobiose (CBI), hence controlling the efficiency and global [...] Read more.
Cyanobacteria are rich sources of secondary metabolites and have the potential to be excellent industrial enzyme producers. β-glucosidases are extensively employed in processing biomass degradation as they mediate the most crucial step of bioconversion of cellobiose (CBI), hence controlling the efficiency and global rate of biomass hydrolysis. However, the production and availability of these enzymes derived from cyanobacteria remains limited. In this study, we evaluated the β-glucosidase from Microcystis aeruginosa CACIAM 03 (MaBgl3) and its potential for bioconversion of cellulosic biomass by analyzing primary/secondary structures, predicting physicochemical properties, homology modeling, molecular docking, and simulations of molecular dynamics (MD). The results showed that MaBgl3 derives from an N-terminal domain folded as a distorted β-barrel, which contains the conserved His–Asp catalytic dyad often found in glycosylases of the GH3 family. The molecular docking results showed relevant interactions with Asp81, Ala271 and Arg444 residues that contribute to the binding process during MD simulation. Moreover, the MD simulation of the MaBgl3 was stable, shown by analyzing the root mean square deviation (RMSD) values and observing favorable binding free energy in both complexes. In addition, experimental data suggest that MaBgl3 could be a potential enzyme for cellobiose-hydrolyzing degradation. Full article
(This article belongs to the Special Issue Advances in Microcystis aeruginosa)
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15 pages, 6514 KiB  
Article
A Promising Use of Trimethyl Chitosan for Removing Microcystis aeruginosa in Water Treatment Processes
by Leda Giannuzzi, Julián Bacciadone and Graciela L. Salerno
Microorganisms 2022, 10(10), 2052; https://doi.org/10.3390/microorganisms10102052 - 18 Oct 2022
Cited by 1 | Viewed by 1568
Abstract
The increase in cyanobacterial blooms linked to climate change and the eutrophication of water bodies is a global concern. The harmful cyanobacterium Microcystis aeruginosa is one of the most common bloom-forming species whose removal from fresh water and, in particular, from that used [...] Read more.
The increase in cyanobacterial blooms linked to climate change and the eutrophication of water bodies is a global concern. The harmful cyanobacterium Microcystis aeruginosa is one of the most common bloom-forming species whose removal from fresh water and, in particular, from that used for water treatment processes, remains a crucial goal. Different biodegradable and environmentally friendly coagulants/flocculants have been assayed, with chitosan showing a very good performance. However, chitosan in its original form is of limited applicability since it is only soluble in acid solution. The objective of this work was therefore to test the coagulant/flocculant capacity of trimethylchitosan (TMC), a chitosan derivative produced from residues of the fishing industry. TMC has a constitutively net positive charge enabling it to remain in solution regardless of the pH. Results show that even at alkaline pHs, common during cyanobacterial blooms, TMC is effective in removing buoyant cyanobacteria from the water column, both in test tube and Jar-Test experiments. Cell integrity was confirmed by fluorescent stain and electron microscopy. Our findings lead us to conclude that the use of TMC to remove bloom cells early in the treatment of drinking water is both feasible and promising. Full article
(This article belongs to the Special Issue Advances in Microcystis aeruginosa)
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14 pages, 1265 KiB  
Article
Environmental Exposure to Cyanobacteria Hepatotoxins in a Pacific Island Community: A Cross-Sectional Assessment
by Brenda Y. Hernandez, Jason Biggs, Xuemei Zhu, Patrick Sotto, Michelle Nagata, Ana Joy Pacilan Mendez and Yvette Paulino
Microorganisms 2022, 10(8), 1607; https://doi.org/10.3390/microorganisms10081607 - 09 Aug 2022
Cited by 1 | Viewed by 1399
Abstract
(1) Background: Cyanobacteria produce a wide range of secondary metabolites, including tumor-promoting hepatotoxins. We recently reported evidence of an independent association between oral cyanobacteria and hepatocellular carcinoma in a U.S. population. We sought to characterize the nature, sources, and health correlates of cyanotoxin [...] Read more.
(1) Background: Cyanobacteria produce a wide range of secondary metabolites, including tumor-promoting hepatotoxins. We recently reported evidence of an independent association between oral cyanobacteria and hepatocellular carcinoma in a U.S. population. We sought to characterize the nature, sources, and health correlates of cyanotoxin exposure in the U.S. Pacific Island territory of Guam, which has a high incidence of liver cancer. (2) Methods: Seventy-four adult males and females were enrolled in a cross-sectional study to quantify cyanotoxins in saliva, urine, and blood and their correlation with health behaviors, medical history, and environmental exposures. Plant samples were collected from locations throughout the island. Microcystin/nodularin (MC/NOD), cylindrospermopsin (CYN), and anabaenopeptin (AB) were measured in biospecimens and in plant extracts by ELISA. (3) Results: Overall, among study participants MC/NOD were detected in 53.9% of saliva, 7.5% of urine, and 100% of serum.; CYN in 40.0% of saliva, 100.0% of urine, and 70.4% of serum; AB in 30.8% of saliva, 85% of urine, and 92.6% of serum. Salivary MC/NOD levels were significantly higher in individuals using municipal tap water as their primary source of drinking water; both salivary and urinary MC/NOD levels were higher in those not using store-bought/commercial water. Urine MC/NOD levels were highest among individuals consuming fruits and vegetables exclusively from local sources. Urine MC/NOD levels were elevated in individuals with hypertension and hyperlipidemia and salivary MC/NOD in those with recent alcohol consumption. Cyanotoxins were prevalent in plant samples including MC/NOD (46.6%), CYN (35.1%), and AB (51.7%). (4) Conclusions: Our study provides evidence that exposure to cyanobacterial hepatotoxins, including tumor promoters, may be prevalent in Guam and may originate from environmental sources. Population-based epidemiologic studies are needed to investigate the role of cyanotoxins in liver cancer development. Full article
(This article belongs to the Special Issue Advances in Microcystis aeruginosa)
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Review

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23 pages, 1111 KiB  
Review
Recent Advances in the Research on the Anticyanobacterial Effects and Biodegradation Mechanisms of Microcystis aeruginosa with Microorganisms
by Yun Kong, Yue Wang, Lihong Miao, Shuhong Mo, Jiake Li and Xing Zheng
Microorganisms 2022, 10(6), 1136; https://doi.org/10.3390/microorganisms10061136 - 31 May 2022
Cited by 6 | Viewed by 2449
Abstract
Harmful algal blooms (HABs) have attracted great attention around the world due to the numerous negative effects such as algal organic matters and cyanobacterial toxins in drinking water treatments. As an economic and environmentally friendly technology, microorganisms have been widely used for pollution [...] Read more.
Harmful algal blooms (HABs) have attracted great attention around the world due to the numerous negative effects such as algal organic matters and cyanobacterial toxins in drinking water treatments. As an economic and environmentally friendly technology, microorganisms have been widely used for pollution control and remediation, especially in the inhibition/biodegradation of the toxic cyanobacterium Microcystis aeruginosa in eutrophic water; moreover, some certain anticyanobacterial microorganisms can degrade microcystins at the same time. Therefore, this review aims to provide information regarding the current status of M. aeruginosa inhibition/biodegradation microorganisms and the acute toxicities of anticyanobacterial substances secreted by microorganisms. Based on the available literature, the anticyanobacterial modes and mechanisms, as well as the in situ application of anticyanobacterial microorganisms are elucidated in this review. This review aims to enhance understanding the anticyanobacterial microorganisms and provides a rational approach towards the future applications. Full article
(This article belongs to the Special Issue Advances in Microcystis aeruginosa)
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