Meningococcal Infections

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Molecular Microbiology and Immunology".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 658

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National Meningitis Reference Laboratory, Laboratory of Infectious Diseases Surveillance, Department of Public Health Policy, School of Public Health, University of West Attica, 115 21 Athens, Greece
Interests: bacterial meningitis; N. meningitidis; S. pneumoniae; H. influenzae
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Dear Colleagues,

Invasive Meningococcal Disease (IMD) is an acute, severe bacterial infection caused by N. meningitidis that can manifest as meningitis and/or septicemia. Rarely, meningococcus can be recovered from unusual sites causing various infections outside the bloodstream or Central Nervous System, such as respiratory, ocular, joint, and urogenital.

During the COVID-19 pandemic period, IMD cases declined; however, during the post-COVID-19 era, an increase in incidence has been observed worldwide. High-quality surveillance is needed to monitor disease incidence trends, serogroup distribution, and strain characterization (‘finetyping’—MLST, porA, and fetA typing; antibiotic resistance; and vaccine antigens).

MDPI’s Microorganisms announces the launch of the Special Issue “Meningococcal Infections”. The aim of this Special Issue is to attract submissions of research articles (original and review articles) concerning trends in IMD epidemiology or new atypical presentations due to N. meningitidis, antibiotic resistance, the emergence of new clones, vaccine coverage, or disease burden studies.

We look forward to receiving your contributions.

Dr. Athanasia Xirogianni
Prof. Dr. Georgina Tzanakaki
Guest Editors

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Keywords

  • meningococcal infections
  • N. meningitidis
  • IMD
  • atypical presentations
  • IMD epidemiology
  • N. meningitidis vaccines

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Published Papers (1 paper)

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9 pages, 548 KB  
Case Report
Two Cases of Rare Manifestations Due to Neisseria meningitidis During the Post-COVID-19 Era in Greece
by Kalliopi Avgoulea, Genovefa Chronopoulou, Athanasia Xirogianni, Stelmos Simantirakis, Theano Georgakopoulou, Anastasios Tsakalos, Constantinos Karamalis, Lampros Nikolopoulos, Fotios Roussos, Maria Gryllia, Nektarios Marmaras, Efterpi Oikonomou, Diagoras Zarganis, Maria Orfanidou, Anastasia Pangalis, Muhamed-Kheir Taha and Georgina Tzanakaki
Microorganisms 2025, 13(9), 2071; https://doi.org/10.3390/microorganisms13092071 - 5 Sep 2025
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Abstract
Background/Objectives: Neisseria meningitidis is a human-specific pathogen capable of causing life-threatening illnesses. Occasionally, it is recovered from unusual sites, other than the bloodstream or the central nervous system. Herein, we describe two rare manifestations due to N. meningitidis within a year (2024) [...] Read more.
Background/Objectives: Neisseria meningitidis is a human-specific pathogen capable of causing life-threatening illnesses. Occasionally, it is recovered from unusual sites, other than the bloodstream or the central nervous system. Herein, we describe two rare manifestations due to N. meningitidis within a year (2024) in Greece. Methods: Atypical infection due to N. meningitidis was diagnosed in two different patients: Case-1 presented with an inflammatory swelling in the mid-line of the neck, and Case-2 presented with swelling of the left knee. Both patients had high fever and no neurological signs at admission; Case-2 progressed to meningoencephalitis. Phenotypic and genotypic identifications were carried out in both cases. Results: Case-1 and Case-2 isolates were identified as follows: MenX: 18, 25-44, F5-5, ST-823; 198cc and MenB: 7-1, 1, F3-3, ST-7460; 32cc for PorA, FetA and MLST, respectively. MenX was identified for the first time in Greece and finetyping revealed rare genotypic characteristics. Both isolates were susceptible to cefotaxime, ceftriaxone and rifampicin, while Case-2 isolate expressed reduced susceptibility to penicillin and resistance to ciprofloxacin. Both patients recovered fully. Conclusions: Although uncommon, N. meningitidis may be isolated from atypical sites and specimens. Clinicians and microbiologists should remain aware that meningococcus is a potential cause of infections beyond meningitis and septicaemia. Full article
(This article belongs to the Special Issue Meningococcal Infections)
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