Biofilm Implant Related Infections, 2nd Edition

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Biofilm".

Deadline for manuscript submissions: 15 October 2024 | Viewed by 92

Special Issue Editor

Guest Editor
Department of Biochemical Sciences for Health, University of Milan, Milan, Italy
Interests: microbiota and probiotics; prosthetic and joint infections; biofilm implant related infections; osteomyelitis; diagnosis for bone-joint infections; antimicrobials and antimicrobial devices
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Biofilm formation is the key factor in the pathogenesis of implant-associated infections. The most common pathogens isolated from such infections are Staphylococcus species, opportunists belonging to the physiological flora of the skin, but other bacteria or fungi can also be involved in these types of infections. Biofilm formation starts with the adhesion of microorganisms and colonization preferentially occurring on the surfaces of a foreign body material. As an interactive symbiotic “city of microbes”, biofilm formation represents an efficient survival strategy for bacteria. In clinically apparent infections, biofilms induce a local host response, involving the infiltration of phagocytic immune cells. Biofilm implant-related infections represent serious acute as well as chronic complications, with high morbidity for the patient and elevated costs for the healthcare system. These infections are typically due to the presence of several bacterial species that are able to produce biofilms. Biofilms are able to adhere to implanted biomaterials (e.g., prosthetic implants, endotracheal tubes, intravenous catheters, indwelling urinary catheters, tissue fillers). Microbial biofilms make infections more refractory to treatment, while slowing tissue repair by stimulating chronic inflammation at the implant site. Preventive measures should be focused primarily on discouraging biofilm formation by protecting implant surfaces with coatings that are able to inhibit bacterial adhesion while maintaining the functional activity of host cells for good implant integration. Further investigations are needed to develop reliable animal models that more closely mimic different infections and allow for the evaluation of the efficacy of surgical procedures as well as systemic or local therapies. To enhance the detection of implant-related infections, additional investigative methods are being explored, such as culture-independent molecular techniques. The purpose of this Research Topic is to provide the reader with an updated overview of infections related to implants. We welcome manuscripts presenting the current state of the art and providing novel scientific knowledge in view of an improvement in the knowledge on implants, new etiologic agents, and biofilm-related infections.

Dr. Lorenzo Drago
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • biofilm-related infections
  • implants
  • diagnosis
  • treatment

Related Special Issue

Published Papers

This special issue is now open for submission.
Back to TopTop