Drug Resistance and Molecular Research of Staphylococcus spp.
A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Medical Microbiology".
Deadline for manuscript submissions: 31 January 2026 | Viewed by 2602
Special Issue Editor
Special Issue Information
Dear Colleagues,
Research on drug resistance and molecular characteristics of various Staphylococcus species, including Staphylococcus aureus, which is classified by the WHO as a high-priority antibiotic-resistant pathogen, and other coagulase-negative staphylococci (CoNS), has focused on several key areas: mechanisms of drug resistance; genomic and molecular studies; epidemiology and surveillance; clinical implications; and new substances and approaches with antimicrobial activity. Despite significant progress, there are several research gaps that need to be addressed:
- Understanding of Resistance Mechanisms: There is limited knowledge of the comprehensive array of genetic determinants and regulatory pathways contributing to drug resistance in diverse Staphylococcus Incomplete understanding of the role of epigenetic modifications and non-genetic factors in resistance development.
- Genomic Diversity and Evolution: Insufficient characterization of the genomic diversity of various Staphylococcus species and how this diversity impacts resistance profiles. Limited insight into the evolutionary dynamics of resistance, including the emergence and dissemination of novel resistance mechanisms.
- Application of Genomic Data: Challenges in translating genomic data into actionable insights for clinical management, treatment selection, and infection control strategies. There is a need for improved tools and platforms for the rapid analysis and interpretation of genomic and molecular data in real-time clinical settings.
- Development of Novel Therapeutics: There is limited clinical data on the efficacy and safety of emerging therapeutic modalities, such as nanoparticles, phage therapy, and antisense antibiotics, specifically for Staphylococcus There is insufficient research into host–pathogen interactions and immunotherapeutic strategies for combating drug-resistant Staphylococcus species.
- Surveillance and Epidemiology: Inadequate integration of surveillance data from diverse geographical regions and healthcare settings, hindering a comprehensive understanding of global resistance trends. Poor understanding of the environmental reservoirs and transmission dynamics of drug-resistant Staphylococcus
For this Special Issue, we encourage researchers to submit original research articles, comprehensive reviews, and communications focusing on the above-mentioned topics, which can advance our understanding of drug resistance and molecular research on Staphylococcus species, leading to improved strategies for combating antimicrobials.
Dr. Jaime Bustos-Martínez
Guest Editor
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Keywords
- immunotherapeutic strategies
- Staphylococcus spp.
- Staphylococcus infection
- genomics
- antimicrobial
- resistance mechanisms
- new antibacterials
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