Special Issue "Recent Advances in Understanding Epstein-Barr Virus"

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Medical Microbiology".

Deadline for manuscript submissions: closed (31 March 2019)

Special Issue Editors

Guest Editor
Prof. Hironori Yoshiyama

Department of Microbiology, Faculty of Medicine, Shimane University, Izumo, Japan
Website | E-Mail
Phone: 81-853-20-2146
Interests: infection-associated cancers; EBV; Helicobacter pylori; micro RNA; immunodeficiency
Guest Editor
Prof. Teru Kanda

Department of Microbiology, Faculty of Medicine, Tohoku Medical Pharmaceutical University, Sendai, Japan
Website | E-Mail
Interests: EBV; viral genome sequencing; reverse genetics; cancer biology; cell biology

Special Issue Information

Dear Colleagues,

The Epstein-Barr virus (EBV) is a human gamma-herpesvirus and more than 90% of population is infected with the virus. EBV infects with oropharyngeal naïve B lymphocytes through saliva then spread to the adjacent B lymphocytes and epithelial cells. Immunological maturation of infected host divides initial infections to asymptomatic infection in infancy and infectious mononucleosis in adolescence. The initial productive lytic infection will shift to persistent latent infection, where limited viral transcripts are expressed to support persistent infection. In most of the cases, EBV associates with the infected person without any symptoms during the person’s life. Primarily resting memory B lymphocytes in peripheral blood provide a permanent reservoir for the virus. However, EBV sometimes shifts from latent to lytic infection in association with local or systemic immunological suppressions. The life long persistence and regional activation may induce oncogenic activation of infected cells in some persons. Thus, EBV sometimes associates with lymphoid or epithelial cancers (Burkitt’s lymphoma, Hodgkin lymphoma, NK/T lymphoma, nasopharyngeal carcinoma, EBV-associated gastric cancers, and so on). EBV-specific immunity controls shift from lytic to latent infection as well as formation of EBV-associated cancers. In order to understand the complex interactions between EBV and host, this Special Issue will collect reviews or original research articles regarding recent advances in Epstein-Barr virus research, which is spanning from basic biology to potential clinical implications.

Prof. Hironori Yoshiyama
Prof. Teru Kanda
Guest Editors

Manuscript Submission Information

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Keywords

  • EBV
  • Helicobacter pylori
  • micro RNA
  • infection-associated cancers
  • immunodeficiency
  • viral genome sequencing
  • reverse genetics
  • cancer biology
  • cell biology

Published Papers (1 paper)

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Review

Open AccessReview Extracellular Vesicles in Epstein-Barr Virus’ Life Cycle and Pathogenesis
Microorganisms 2019, 7(2), 48; https://doi.org/10.3390/microorganisms7020048
Received: 28 January 2019 / Revised: 8 February 2019 / Accepted: 9 February 2019 / Published: 11 February 2019
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Abstract
Extracellular vesicles (EVs), including exosomes and microvesicles, are evolutionarily conserved phospholidpid membrane-bound entities secreted from most eukaryotic cell types. They carry bioactive cargos such as protein and nucleic acids derived from their cells of origin. Over the past 10 years, they have been [...] Read more.
Extracellular vesicles (EVs), including exosomes and microvesicles, are evolutionarily conserved phospholidpid membrane-bound entities secreted from most eukaryotic cell types. They carry bioactive cargos such as protein and nucleic acids derived from their cells of origin. Over the past 10 years, they have been attracting increased attention in many fields of life science, representing a new route for intercellular communication. In this review article, we will discuss the current knowledge of both normal and virally modified EVs in the regulation of Epstein-Barr virus (EBV)’s life cycle and its associated pathogenesis. Full article
(This article belongs to the Special Issue Recent Advances in Understanding Epstein-Barr Virus)
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