Foodborne Pathogens: Infections and Pathogenesis of Microorganisms (Second Edition)

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Food Microbiology".

Deadline for manuscript submissions: closed (31 December 2024) | Viewed by 20793

Special Issue Editors


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Guest Editor
Department of Infectious Diseases, National Institute of Health Dr Ricardo Jorge, 1649-016 Lisbon, Portugal
Interests: foodborne pathogen; molecular epidemiology; AMR; virulence
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Guest Editor
National Institute for Agrarian and Veterinary Research, Oeiras, Portugal
Interests: molecular microbiology; one health
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Special Issue Information

Dear Colleagues,

This Special Issue is the continuation of our previous Special Issue titled ‘Foodborne Pathogens: Infections and Pathogenesis’, which was published in 2022. 

Foodborne microorganisms have a major effect on food safety, causing a great number of human infectious diseases worldwide, thereby significantly impacting public health and the economy. Animals are the major reservoirs of many foodborne zoonotic bacterial pathogens, and food products of animal origin are the main vehicles of transmission. Thus, consumption of animal products contaminated with vegetative pathogens or their toxins are the main source of illness, since most of these microbes are zoonotic.  Bacteria are the causative agents of two-thirds of human foodborne diseases worldwide, with a particularly high burden in developing countries. S. aureusSalmonella species, Campylobacter species, L. monocytogenes, and E. coli are the major zoonotic bacterial pathogens. Viruses (e.g., Hepatitis A and Noroviruses, among others) and parasites (e.g., Toxoplasma gondii and Trichinella spiralis) are also important causative agents of foodborne diseases. Currently, the emergence of multidrug-resistant zoonotic bacteria associated with the consumption of contaminated animal products is a great concern for public health.

This Special Issue aims to collate recent research on the infection and pathogenesis of foodborne pathogens. We cordially invite microbiology professionals, specifically food microbiologists, clinical and veterinary microbiologists, as well researchers and academics involved in food microbiology and food safety-related research or teaching to submit their manuscripts. This Special Issue will cover the following topics:

  • Foodborne zoonotic bacterial pathogens;
  • Molecular and cellular mechanisms of infection;
  • Virulence factors and their regulation in the host and in the environment;
  • Production of toxins in the outcome of foodborne infections;
  • Pathogenicity models;
  • Host–pathogen interaction;
  • The role of the immune system in the disease process;
  • The role of microbiota in the disease process;
  • Biofilm production and the outcome of foodborne infections;
  • Antimicrobial resistance, including novel mechanisms;
  • Foodborne parasites;
  • Viral foodborne agents;
  • Food safety: Control of foodborne pathogens.

Dr. Mónica Oleastro
Dr. Ana Botelho
Guest Editors

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Keywords

  • foodborne zoonotic bacterial pathogens
  • host-pathogen interaction
  • virulence
  • toxins
  • biofilms
  • gut microbioma
  • antimicrobial resistance
  • foodborne parasites
  • viral foodborne agents
  • salmonella
  • campylobacter
  • listeria
  • food safety

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Published Papers (3 papers)

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Research

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15 pages, 2589 KiB  
Article
Involvement of Campylobacter Species in Spotty Liver Disease-like Lesions in Broiler Chickens Detected at Meat Inspections in Miyazaki Prefecture, Japan
by Piyarat Jiarpinitnun, Akira Iwakiri, Naoyuki Fuke, Pornsawan Pongsawat, Chizuru Miyanishi, Satomi Sasaki, Takako Taniguchi, Yuto Matsui, Taradon Luangtongkum, Kentaro Yamada and Naoaki Misawa
Microorganisms 2024, 12(12), 2442; https://doi.org/10.3390/microorganisms12122442 - 27 Nov 2024
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Abstract
Spotty liver disease (SLD) affects free-range laying hens, leading to mortality and reduced egg production. Campylobacter species, including Campylobacter hepaticus, have been associated with SLD cases worldwide. However, the cause of SLD-like lesions found in broilers in Japan still remains unclear. The [...] Read more.
Spotty liver disease (SLD) affects free-range laying hens, leading to mortality and reduced egg production. Campylobacter species, including Campylobacter hepaticus, have been associated with SLD cases worldwide. However, the cause of SLD-like lesions found in broilers in Japan still remains unclear. The present study aimed to investigate the involvement of Campylobacter spp. in broiler SLD by conducting microbiological, molecular biological, serological, histopathological, and immunohistopathological examinations using specimens of liver, bile, cecum, and serum from SLD-like and non-SLD chickens. C. jejuni was predominantly isolated and detected in approximately 40% of both non-SLD livers and SLD-like livers, with no significant difference between them. However, C. hepaticus was neither isolated nor detected in this study. Gross and histopathology revealed multifocal necrotizing hepatitis, suppurative granulomatous hepatitis, and cholangiohepatitis. Hepatitis stages are classified as no hepatitis, subclinical, acute, and chronic hepatitis. C. jejuni was more frequently present in acute-stage SLD-like livers, and high IgG antibody levels were noted in both subclinical and SLD-like-affected chickens, indicating C. jejuni infection. Immunohistochemical examination also supported these findings. The findings suggest that C. hepaticus was not involved in SLD-like in broilers in Japan, but C. jejuni translocation from the intestines to the liver may be a contributing factor. Full article
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11 pages, 1252 KiB  
Article
Prevalence, Antimicrobial Susceptibility, and Resistance Genes of Extended-Spectrum β-Lactamase-Producing Escherichia coli from Broilers Sold in Open Markets of Dakar, Senegal
by Abdoulaye Cissé, Bissoume Sambe Ba, Ousmane Sow, Abdoul Aziz Wane, Issa Ndiaye, Cheikh Fall, Makhtar Camara and Yakhya Dieye
Microorganisms 2024, 12(11), 2357; https://doi.org/10.3390/microorganisms12112357 - 19 Nov 2024
Cited by 3 | Viewed by 1201
Abstract
Extended-spectrum β-lactamase-producing Escherichia coli (ESBL-Ec) poses a significant public health concern due to its widespread prevalence and resistance to multiple antibiotics. This study aimed to assess the prevalence, resistance profile, and carriage of ESBL-encoding genes in ESBL-Ec isolates from broilers [...] Read more.
Extended-spectrum β-lactamase-producing Escherichia coli (ESBL-Ec) poses a significant public health concern due to its widespread prevalence and resistance to multiple antibiotics. This study aimed to assess the prevalence, resistance profile, and carriage of ESBL-encoding genes in ESBL-Ec isolates from broilers in two markets of Dakar, Senegal. Sampling over a one-year period revealed that 61.7% of broilers carried ESBL-Ec in their cecum. Antibiotic susceptibility testing of 186 ESBL-Ec isolates showed high resistance to β-lactam antibiotics, including ampicillin, ticarcillin, and third-generation cephalosporins. Notably, all isolates were susceptible to imipenem. Multidrug resistance was frequent, with 91.4% of the isolates displaying this phenotype. Comparison between the two markets revealed variations in resistance to quinolones. PCR analysis detected blaCTX-M genes in all isolates, with blaCTX-M-1 being the most prevalent subgroup. Additionally, blaTEM and blaOXA genes were found in 26.3% and 2.7% of isolates, respectively, while no blaSHV genes were detected. Combinations of ESBL genes were common, with blaCTX-M15-blaTEM being the most frequent. These findings highlight the widespread prevalence of ESBL-Ec in broilers from Dakar markets, indicating a potential risk of transmission to humans through the food chain. Effective surveillance and intervention strategies are crucial to mitigate the spread of antimicrobial resistance in humans and animals. Full article
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Review

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27 pages, 1729 KiB  
Review
Salmonella Infection in Poultry: A Review on the Pathogen and Control Strategies
by Syamily Shaji, Ramesh K. Selvaraj and Revathi Shanmugasundaram
Microorganisms 2023, 11(11), 2814; https://doi.org/10.3390/microorganisms11112814 - 20 Nov 2023
Cited by 63 | Viewed by 17659
Abstract
Salmonella is the leading cause of food-borne zoonotic disease worldwide. Non-typhoidal Salmonella serotypes are the primary etiological agents associated with salmonellosis in poultry. Contaminated poultry eggs and meat products are the major sources of human Salmonella infection. Horizontal and vertical transmission are the [...] Read more.
Salmonella is the leading cause of food-borne zoonotic disease worldwide. Non-typhoidal Salmonella serotypes are the primary etiological agents associated with salmonellosis in poultry. Contaminated poultry eggs and meat products are the major sources of human Salmonella infection. Horizontal and vertical transmission are the primary routes of infection in chickens. The principal virulence genes linked to Salmonella pathogenesis in poultry are located in Salmonella pathogenicity islands 1 and 2 (SPI-1 and SPI-2). Cell-mediated and humoral immune responses are involved in the defense against Salmonella invasion in poultry. Vaccination of chickens and supplementation of feed additives like prebiotics, probiotics, postbiotics, synbiotics, and bacteriophages are currently being used to mitigate the Salmonella load in poultry. Despite the existence of various control measures, there is still a need for a broad, safe, and well-defined strategy that can confer long-term protection from Salmonella in poultry flocks. This review examines the current knowledge on the etiology, transmission, cell wall structure, nomenclature, pathogenesis, immune response, and efficacy of preventative approaches to Salmonella. Full article
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