Active Components of Natural Products as New Antimicrobial Agents

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Antimicrobial Agents and Resistance".

Deadline for manuscript submissions: closed (30 June 2024) | Viewed by 1728

Special Issue Editor


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Guest Editor
Faculty of Agrobiotechnical Sciences Osijek, Josip Juraj Strossmayer University of Osijek, Vladimira Preloga 1, 31000 Osijek, Croatia
Interests: polyphenols; ROS; antioxidant activity; enzyme activity; kinetics
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Special Issue Information

Dear Colleagues,

Microorganisms invites researchers to contribute to the Special Issue focused on exploring the active components of natural products as new antimicrobial agents.

We welcome original research, reviews, and communications on the identification, isolation, and characterization of bioactive compounds derived from natural sources. Studies elucidating the mechanisms of action, antimicrobial efficacy, and synergistic effects of these active components are highly encouraged.

Contributions investigating the therapeutic potential of natural products against bacterial, viral, fungal, and parasitic pathogens are welcome. Additionally, research on the development of formulations, delivery systems, and the exploration of structure-activity relationships will provide valuable insights for the development of next-generation antimicrobials.

By fostering collaboration between researchers in natural product chemistry, microbiology, and drug development, this Special Issue aims to advance our knowledge of natural compounds as antimicrobial agents. The findings presented will contribute to the development of innovative and sustainable strategies for combating microbial infections.

Dr. Drago Bešlo
Guest Editor

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Keywords

  • natural products
  • antimicrobial agents
  • active components
  • bioactive compounds
  • antimicrobial resistance
  • drug development

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Published Papers (1 paper)

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Research

15 pages, 287 KiB  
Article
Antibiofilm Effects of Plant Extracts Against Staphylococcus aureus
by Alexia Barbarossa, Antonio Rosato, Roberta Tardugno, Antonio Carrieri, Filomena Corbo, Francesco Limongelli, Luciana Fumarola, Giuseppe Fracchiolla and Alessia Carocci
Microorganisms 2025, 13(2), 454; https://doi.org/10.3390/microorganisms13020454 - 19 Feb 2025
Viewed by 1259
Abstract
The global rise in antimicrobial resistance poses a significant threat to public health, necessitating alternative therapeutic options. One critical challenge is treating infections caused by biofilm-forming bacteria, which are notably resistant to conventional antibiotics. Staphylococcus aureus, including methicillin-resistant strains (MRSA), is a [...] Read more.
The global rise in antimicrobial resistance poses a significant threat to public health, necessitating alternative therapeutic options. One critical challenge is treating infections caused by biofilm-forming bacteria, which are notably resistant to conventional antibiotics. Staphylococcus aureus, including methicillin-resistant strains (MRSA), is a major pathogen in biofilm-related infections, complicating treatment and leading to chronic cases. Plant extracts have emerged as promising alternatives, offering new avenues for effective treatment. This study evaluated the antibacterial and antibiofilm activities of commercial extracts of Vitis vinifera L. (grape), Camellia sinensis L. (green tea), Olea europaea L. (olive), Quercus robur (oak), and Coffea arabica L. (coffee) against S. aureus strains from ATCC collections and clinical isolates. Preliminary screening using the disk diffusion test assessed the zones of inhibition, which was followed by minimum inhibitory concentration (MIC) determination via broth microdilution, with Quercus robur L. showing the best overall MIC results. The results obtained demonstrate the strong antibacterial activity of the extracts, with the MIC values ranging from 0.2 to 12.4 mg/mL. Using the XTT reduction assay, the extracts inhibited biofilm growth by 80–85% after 24 h of incubation, with Coffea arabica L. achieving interesting antibiofilm activities. These findings suggest that the investigated plant extracts hold potential as antimicrobial agents and biofilm inhibitors, offering an alternative approach to tackling antimicrobial resistance. Further research is needed to explore their potential applications in developing novel adjuvant therapies. Full article
(This article belongs to the Special Issue Active Components of Natural Products as New Antimicrobial Agents)
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