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Microorganisms
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Innovative Coating Materials: New Approaches in the Fight against Microbial...
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Innovative Coating Materials: New Approaches in the Fight against Microbial Pathogens and Antimicrobial Resistance

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Antimicrobial Agents and Resistance".

Deadline for manuscript submissions: closed (18 February 2022) | Viewed by 2198

Special Issue Editor

Prof. Dr. Roger Pickup

E-Mail Website
Guest Editor
Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, B078 Furness Building, Lancaster LA1 4YQ, UK
Interests: microbiology; MAP; Johne’s disease; ecology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Antimicrobial resistance (AMR) threatens the effective prevention and treatment of an ever-increasing range of infections caused by bacteria, parasites, viruses, and fungi.

AMR occurs when bacteria, viruses, fungi, and parasites no longer respond to antimicrobials, making infections harder to treat and increasing the risk of disease spread, severe illness, and death. Their eradication is a key focus in healthcare. Alternatives to prescribed antimicrobial compounds are urgently needed and relevant areas of research include the development of antimicrobial surfaces that contain agents that inhibit or kill microorganisms. Such surfaces are becoming more widely investigated for possible use in various settings including clinics, industry, and even the home. In addition to medical devices, this technology can be applied to any surface where the inhibition or removal of microorganisms is required. This Special Issue will showcase new, innovative antimicrobial surfaces and their potential and efficiencies.

Prof. Dr. Roger Pickup
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bacteria
  • fungi
  • viruses
  • infection
  • control
  • antimicrobial surfaces
  • antimicrobial resistances
  • alternative technologies

Published Papers (1 paper)

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Research

11 pages, 2102 KiB  
Article
PDIA, an Iminosugar Compound with a Wide Biofilm Inhibitory Spectrum Covering Both Gram-Positive and Gram-Negative Human Bacterial Pathogens
by Łucja Kozień, Estelle Gallienne, Olivier Martin, Sophie Front, Magdalena Strus and Piotr Heczko
Microorganisms 2022, 10(6), 1222; https://doi.org/10.3390/microorganisms10061222 - 15 Jun 2022
Viewed by 1623
Abstract
Many difficult-to-treat human infections related to catheters and other indwelling devices are caused by bacteria residing in biofilms. One of the key properties of microorganisms residing in a biofilm is decreased susceptibility towards antimicrobial agents. Therefore, many different approaches have been researched to [...] Read more.
Many difficult-to-treat human infections related to catheters and other indwelling devices are caused by bacteria residing in biofilms. One of the key properties of microorganisms residing in a biofilm is decreased susceptibility towards antimicrobial agents. Therefore, many different approaches have been researched to destroy or inhibit biofilm production by bacteria. Different iminosugars (IS) were reported to inhibit biofilm formation in S. mutans, S. aureus, and P. aeruginosa. The aim of this study was to look for a spectrum of the activity in one of these IS. The iminosugar PDIA beta-1-C-propyl-1,4-dideoxy-1,4-imino-L-arabinitol was tested in vitro at the same concentration against 30 different strains of the most important Gram-negative and Gram-positive human pathogens looking for their biofilm production and viability at different time intervals. It appeared that PDIA inhibited biofilm production of Enterobacter spp., P. aeruginosa, Enterococcus spp. and S. aureus in 8 h, and Klebsiella spp., Acinetobacter spp. and S.epidermidis in 24 h. PDIA caused no growth inhibition of the tested bacteria at a concentration of 0.9 mM. Our results indicate a broad-spectrum biofilm inhibitory activity of PDIA. which may be the basis for future application studies that will help in control of the associated device and biofilm-related infections caused by a wide spectrum of the causative agents. Full article
(This article belongs to the Special Issue Innovative Coating Materials: New Approaches in the Fight against Microbial Pathogens and Antimicrobial Resistance)
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