Bacterial Communication: The Quorum Sensing Paradigm
A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Biofilm".
Deadline for manuscript submissions: 15 October 2025 | Viewed by 282
Special Issue Editor
Special Issue Information
Dear Colleagues,
Communication is the key to all living organisms' survival, growth, and development. Cell communication in bacteria is dependent on the production and response of autoinducers. Autoinducers are small pheromone biochemical molecules used by bacteria to communicate and release via the process of quorum sensing. Quorum sensing is cell communication where the quorum sensing molecules (autoinducers) are excreted into the extracellular environment and used for communicating with other cells. Quorum sensing signals bind to receptors and regulate gene expression and physiological activities through a chain of cascade reactions such as the formation of biofilms, enzyme secretion, virulence factor expression, and so on. Gram-negative quorum-sensing bacteria use small molecules as autoinducers, and two types of cognate receptors detect these autoinducers—cytoplasmic transcription factors or transmembrane two-component histidine sensor kinases. Gram-positive bacteria typically use oligopeptides as autoinducers, and the partner receptors are transmembrane two-component histidine sensor kinases15. Understanding bacterial quorum sensing will lead to identifying and developing therapeutic targets for mitigating infectious diseases. In this Special Issue of Microorganisms, we welcome contributions (original articles as well as reviews) related to bacterial communication based on quorum sensing, crosstalk of the bacterial organisms, virulence related to quorum sensing, biofilms, development of therapeutic agents using the quorum sensing paradigm, stress response, and molecular biology. We encourage researchers to send their work on recent advancements in quorum sensing to this Special Issue.
Dr. Ritika Gupta
Guest Editor
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Keywords
- communication
- crosstalk
- virulence
- biofilms
- autoinducers
- therapeutic targets
- infectious diseases
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