Effects of Gut Microbiota on Human Health and Disease, 2nd Edition

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Gut Microbiota".

Deadline for manuscript submissions: 15 August 2025 | Viewed by 689

Special Issue Editor


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Guest Editor
College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China
Interests: animal internal medicine and toxic diseases; animal nutritional metabolic diseases and immunity; intestinal microbes; probiotic fermentation; obesity; liver fibrosis; cholestatic liver injury
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Special Issue Information

Dear Colleagues,

This Special Issue is a continuation of our previous Special Issue, “Effects of Gut Microbiota on Human Health and Disease” (https://www.mdpi.com/journal/microorganisms/special_issues/K1J57T17SY).

Intestinal microbiota may contribute to human health and disease. However, to gain a mechanistic understanding of how the gut microbiota affect human health and disease, the current research is moving away from descriptive microbiota census analyses toward cause-and-effect studies. Joint analyses of high-throughput human multi-omics data, including metagenomics and metabolomics data, together with measures of host physiology and mechanistic experiments in humans, hold potential as initial steps in the identification of potential molecular mechanisms behind previously reported associations. Through this topic, we will discuss the current knowledge of how the gut microbiota and derived microbial compounds may be linked to the metabolism of a healthy human host or to the pathogenesis of common human diseases. We will highlight examples of microbiota-targeted interventions aiming to optimize metabolic health and provide perspectives for future basic and translational investigations within this nascent and promising research field.

The aim of this Special Issue of Microorganisms is to present a collection of articles that provide a snapshot of current research into the effects of the gut microbiota on human health and disease. Manuscripts covering all aspects of research relating to this area are welcome.

Dr. Yunhuan Liu
Guest Editor

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Keywords

  • gut microbiota
  • human health
  • human disease
  • virus
  • microorganism
  • nutrition
  • metabolic disease
  • liver
  • gut
  • kidney

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Published Papers (1 paper)

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Research

13 pages, 717 KiB  
Article
The Prevalence of Polyketide Synthase-Positive E. coli in Cystic Fibrosis
by Christopher Chan, Michael Coffey, Caitlin Murphy, Isabelle McKay, Jumaana Abdu, Keerti Paida, Rachel Y. Tam, Hannah Wrigley-Carr, Bernadette Prentice, Louisa Owens, Yvonne Belessis, Sandra Chuang, Adam Jaffe, Josie van Dorst and Chee Y. Ooi
Microorganisms 2025, 13(3), 681; https://doi.org/10.3390/microorganisms13030681 - 18 Mar 2025
Viewed by 441
Abstract
Cystic fibrosis (CF) patients experience higher risks of colorectal cancer but the pathogenesis is unclear. In the general population, polyketide synthase-positive (pks+) E. coli is implicated in intestinal carcinogenesis via the production of colibactin; however, the relevance in CF is unknown. In [...] Read more.
Cystic fibrosis (CF) patients experience higher risks of colorectal cancer but the pathogenesis is unclear. In the general population, polyketide synthase-positive (pks+) E. coli is implicated in intestinal carcinogenesis via the production of colibactin; however, the relevance in CF is unknown. In this study, we investigate pks+E. coli prevalence in CF and potential associations between pks+E. coli, gastrointestinal inflammation, and microbiome dynamics with fecal calprotectin and 16SrRNA gene taxonomic data. Cross-sectional analysis demonstrated no difference in pks+E. coli carriage between CF patients and healthy controls, 21/55 (38%) vs. 26/55 (47%), p = 0.32. Pks+E. coli was not associated with significant differences in mean (SD) calprotectin concentration (124 (154) vs. 158 (268) mg/kg; p = 0.60), microbial richness (159 (76.5) vs. 147 (70.4); p = 0.50) or Shannon diversity index (2.78 (0.77) vs. 2.65 (0.74); p = 0.50) in CF. Additionally, there was no association with exocrine pancreatic status (p = 0.2) or overall antibiotic use (p = 0.6). Longitudinally, CF subjects demonstrated intra-individual variation in pks+E. coli presence but no significant difference in overall prevalence. Future investigation into the effects of repeat exposure on risk profile and analysis of older CF cohorts is necessary to identify if associations with colorectal cancer exist. Full article
(This article belongs to the Special Issue Effects of Gut Microbiota on Human Health and Disease, 2nd Edition)
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