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Effects of Gut Microbiota on Human Health and Disease, 2nd...
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Effects of Gut Microbiota on Human Health and Disease, 2nd Edition

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Gut Microbiota".

Deadline for manuscript submissions: 15 August 2025 | Viewed by 1549

Special Issue Editor

Dr. Yunhuan Liu

E-Mail Website
Guest Editor
College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China
Interests: animal internal medicine and toxic diseases; animal nutritional metabolic diseases and immunity; intestinal microbes; probiotic fermentation; obesity; liver fibrosis; cholestatic liver injury
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is a continuation of our previous Special Issue, “Effects of Gut Microbiota on Human Health and Disease” (https://www.mdpi.com/journal/microorganisms/special_issues/K1J57T17SY).

Intestinal microbiota may contribute to human health and disease. However, to gain a mechanistic understanding of how the gut microbiota affect human health and disease, the current research is moving away from descriptive microbiota census analyses toward cause-and-effect studies. Joint analyses of high-throughput human multi-omics data, including metagenomics and metabolomics data, together with measures of host physiology and mechanistic experiments in humans, hold potential as initial steps in the identification of potential molecular mechanisms behind previously reported associations. Through this topic, we will discuss the current knowledge of how the gut microbiota and derived microbial compounds may be linked to the metabolism of a healthy human host or to the pathogenesis of common human diseases. We will highlight examples of microbiota-targeted interventions aiming to optimize metabolic health and provide perspectives for future basic and translational investigations within this nascent and promising research field.

The aim of this Special Issue of Microorganisms is to present a collection of articles that provide a snapshot of current research into the effects of the gut microbiota on human health and disease. Manuscripts covering all aspects of research relating to this area are welcome.

Dr. Yunhuan Liu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gut microbiota
  • human health
  • human disease
  • virus
  • microorganism
  • nutrition
  • metabolic disease
  • liver
  • gut
  • kidney

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Related Special Issue

Published Papers (2 papers)

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Research

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13 pages, 717 KiB  
Article
The Prevalence of Polyketide Synthase-Positive E. coli in Cystic Fibrosis
by Christopher Chan, Michael Coffey, Caitlin Murphy, Isabelle McKay, Jumaana Abdu, Keerti Paida, Rachel Y. Tam, Hannah Wrigley-Carr, Bernadette Prentice, Louisa Owens, Yvonne Belessis, Sandra Chuang, Adam Jaffe, Josie van Dorst and Chee Y. Ooi
Microorganisms 2025, 13(3), 681; https://doi.org/10.3390/microorganisms13030681 - 18 Mar 2025
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Abstract
Cystic fibrosis (CF) patients experience higher risks of colorectal cancer but the pathogenesis is unclear. In the general population, polyketide synthase-positive (pks+) E. coli is implicated in intestinal carcinogenesis via the production of colibactin; however, the relevance in CF is unknown. In [...] Read more.
Cystic fibrosis (CF) patients experience higher risks of colorectal cancer but the pathogenesis is unclear. In the general population, polyketide synthase-positive (pks+) E. coli is implicated in intestinal carcinogenesis via the production of colibactin; however, the relevance in CF is unknown. In this study, we investigate pks+E. coli prevalence in CF and potential associations between pks+E. coli, gastrointestinal inflammation, and microbiome dynamics with fecal calprotectin and 16SrRNA gene taxonomic data. Cross-sectional analysis demonstrated no difference in pks+E. coli carriage between CF patients and healthy controls, 21/55 (38%) vs. 26/55 (47%), p = 0.32. Pks+E. coli was not associated with significant differences in mean (SD) calprotectin concentration (124 (154) vs. 158 (268) mg/kg; p = 0.60), microbial richness (159 (76.5) vs. 147 (70.4); p = 0.50) or Shannon diversity index (2.78 (0.77) vs. 2.65 (0.74); p = 0.50) in CF. Additionally, there was no association with exocrine pancreatic status (p = 0.2) or overall antibiotic use (p = 0.6). Longitudinally, CF subjects demonstrated intra-individual variation in pks+E. coli presence but no significant difference in overall prevalence. Future investigation into the effects of repeat exposure on risk profile and analysis of older CF cohorts is necessary to identify if associations with colorectal cancer exist. Full article
(This article belongs to the Special Issue Effects of Gut Microbiota on Human Health and Disease, 2nd Edition)
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Review

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29 pages, 1355 KiB  
Review
The Effects of Fecal Microbial Transplantation on the Symptoms in Autism Spectrum Disorder, Gut Microbiota and Metabolites: A Scoping Review
by Ignazio Maniscalco, Piotr Bartochowski, Vittoria Priori, Sidonia Paula Iancau, Michele De Francesco, Marco Innamorati, Natalia Jagodzinska, Giancarlo Giupponi, Luca Masucci, Andreas Conca and Magdalena Mroczek
Microorganisms 2025, 13(6), 1290; https://doi.org/10.3390/microorganisms13061290 - 31 May 2025
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Abstract
The bilateral interaction between the brain and the gut has recently been on the spectrum of researchers’ interests, including complex neural, endocrinological, and immunological signaling pathways. The first case reports and clinical studies have already reported that delivering microbes through fecal microbial transplantation [...] Read more.
The bilateral interaction between the brain and the gut has recently been on the spectrum of researchers’ interests, including complex neural, endocrinological, and immunological signaling pathways. The first case reports and clinical studies have already reported that delivering microbes through fecal microbial transplantation (FMT) may alleviate symptoms of psychiatric disorders. Therefore, modifying the gut microbiota through FMT holds promise as a potential treatment for psychiatric diseases. This scoping review assessed studies from PubMed related to FMT in autism spectrum disorder and attention deficit hyperactivity disorder. The evaluation included nine clinical studies and case reports. The beneficial and persistent effect on the autism spectrum disorder (ASD) symptoms has been reported. Also, an increased microflora diversity and altered levels of neurometabolites in serum were identified, albeit with a tendency to return to baseline over time. The microbiome–gut–brain axis could provide new targets for preventing and treating psychiatric disorders. However, a recent large randomized clinical trial has shed light on the previously collected data and suggested a possible contribution of the placebo effect. This highlights the necessity of large randomized double-blind studies to reliably assess the effect of FMT in ASD. Full article
(This article belongs to the Special Issue Effects of Gut Microbiota on Human Health and Disease, 2nd Edition)
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