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Eukaryotic Microbial Sex: A Path to a Unified Understanding of...
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Eukaryotic Microbial Sex: A Path to a Unified Understanding of Seven Major Supergroups

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Molecular Microbiology and Immunology".

Deadline for manuscript submissions: 31 October 2024 | Viewed by 2217

Special Issue Editor

Prof. Dr. Nobuyuki Haga

E-Mail Website
Guest Editor
Department of Biological Sciences, Faculty of Science and Technology, Senshu University of Ishinomaki, Miyagi 986-8580, Japan
Interests: cell biology; mating type inheritance in paramecium; mating reaction; clonal development and aging

Special Issue Information

Dear Colleagues,

This Special Issue explores the sexual diversity and commonalities of microbial eukaryotes across seven major eukaryotic supergroups. Sexual reproduction introduces genetic diversity into the offspring's genomes. The variations that emerge in the descendants' genomes can be attributed to the distinct responses of individual biological populations to natural selection. Our focus is on comprehending and investigating the evolutionary forces behind sexual reproduction present in seven major supergroups.

We are seeking submissions on the following topics:
(1) Reproductive strategies and environmental adaptation;
(2) Diversity of reproductive modes;
(3) Genetic diversity and adaptation;
(4) Mechanisms of sex determination;
(5) Molecular biological methods for sex determination;
(6) Diversity of sex hormone molecules;
(7) Relationship between symbiosis and sex;
(8) Origin and evolution of sex;
(9) Construction of evolutionary scenarios;
(10) Contribution to applied fields.

We encourage research findings on organisms with new and unknown characteristics, as well as organisms with a history as model organisms in research. We anticipate that this Special Issue will contribute to a deeper understanding of the evolution of sex in eukaryotes and offer new perspectives on the mechanisms of sexual diversity and evolution.

Prof. Dr. Nobuyuki Haga
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • mating type determination
  • mating-type inheritance
  • mating type substances and genes
  • mating pheromones
  • genomic DNA rearrangement
  • meiosis and gamete genesis

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Published Papers (2 papers)

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Research

26 pages, 4848 KiB  
Article
Identification and Characterization of the Gene Responsible for the O3 Mating Type Substance in Paramecium caudatum
by Yuta Chiba, Yasuhiro Takenaka and Nobuyuki Haga
Microorganisms 2024, 12(3), 588; https://doi.org/10.3390/microorganisms12030588 - 15 Mar 2024
Viewed by 1117
Abstract
The process of sexual reproduction in eukaryotes starts when gametes from two different sexes encounter each other. Paramecium, a unicellular eukaryote, undergoes conjugation and uses a gametic nucleus to enter the sexual reproductive process. The molecules responsible for recognizing mating partners, hypothetically [...] Read more.
The process of sexual reproduction in eukaryotes starts when gametes from two different sexes encounter each other. Paramecium, a unicellular eukaryote, undergoes conjugation and uses a gametic nucleus to enter the sexual reproductive process. The molecules responsible for recognizing mating partners, hypothetically called mating-type substances, are still unclear. We have identified an O3-type mating substance polypeptide and its gene sequence using protein chemistry, molecular genetics, immunofluorescence, RNA interference, and microinjection. The O3-type substance is a polypeptide found in the ciliary membranes, located from the head to the ventral side of cells. The O3-type substance has a kinase-like domain in its N-terminal part located outside the cell and four EF-hand motifs that bind calcium ions in its C-terminal part located inside the cell. RNA interference and immunofluorescence revealed that this polypeptide positively correlated with the expression of mating reactivity. Microinjection of an expression vector incorporating the O3Pc-MSP gene (Oms3) induced additional O3 mating type in the recipient clones of different mating types or syngen. Phylogenetic analysis indicates that this gene is widely present in eukaryotes and exhibits high homology among closely related species. The O3Pc-MSP (Oms3) gene had nine silent mutations compared to the complementary mating type of the E3 homologue gene. Full article
(This article belongs to the Special Issue Eukaryotic Microbial Sex: A Path to a Unified Understanding of Seven Major Supergroups)
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16 pages, 3324 KiB  
Article
Mating Pheromone (Gamone 1) in Blepharisma: A Glycoprotein Responsible for Species Diversity in Unicellular Organisms (Alveolata, Ciliophora)
by Mayumi Kobayashi, Mayumi Sugiura, Shoko Iwasaki, Naoyuki Iwabe and Terue Harumoto
Microorganisms 2024, 12(2), 299; https://doi.org/10.3390/microorganisms12020299 - 30 Jan 2024
Viewed by 746
Abstract
The genus Blepharisma (Alveolata, Ciliophora) is a unicellular organism distributed worldwide, even in extreme environments, and comprises numerous species. While usually proliferating through cell division, Blepharisma undergoes sexual reproduction (conjugation) when cells are moderately starved. Conjugation is initiated by mating pheromones (gamone 1 [...] Read more.
The genus Blepharisma (Alveolata, Ciliophora) is a unicellular organism distributed worldwide, even in extreme environments, and comprises numerous species. While usually proliferating through cell division, Blepharisma undergoes sexual reproduction (conjugation) when cells are moderately starved. Conjugation is initiated by mating pheromones (gamone 1 and gamone 2) secreted by complementary mating-type cells. Gamone 1, a glycoprotein, functions in a species-specific manner, while gamone 2, an amino acid derivative, is a common molecule across species. The specific function of gamone 1 suggests the possibility that mutations in gamone 1 might have led to reproductive isolation during the evolutionary process, triggering species diversification. In this study, by comparing the amino acid sequences of gamone 1 homologs from 15 strains (representing five species), we found that mutations resulting in distinct amino acid properties occur across species boundaries and are mainly concentrated at two specific regions within gamone 1. These mutations potentially alter the binding affinity of gamone 1 to its receptors, suggesting their effect in causing reproductive isolation. The interspecies artificial conjugation conducted previously and the molecular phylogenetic tree constructed using the gamone 1 homolog sequences in this study provide insights into the speciation process within the genus Blepharisma. Full article
(This article belongs to the Special Issue Eukaryotic Microbial Sex: A Path to a Unified Understanding of Seven Major Supergroups)
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