Viral Infection on Swine: Pathogenesis, Diagnosis and Control

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Veterinary Microbiology".

Deadline for manuscript submissions: 15 June 2025 | Viewed by 652

Special Issue Editor


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Guest Editor
Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Beijing, China
Interests: porcine reproductive and respiratory syndrome virus; non-coding RNA; virus-host interactions
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Special Issue Information

Dear Colleagues,

Viruses are an important research subject worldwide because of their serious threat to the swine industry. A lack of knowledge of the mode of variation and transmission of the swine viruses makes it difficult to fight the infection and develop effective vaccines. The epidemic potential of viruses is a result of the high variability of their genome and is correlated with their proliferation and pathogenicity. In the fight against porcine infectious diseases, research indicating the mechanisms by which viruses occur, with mutation and virulence increasing, their adaptability, efficient diagnosis and surveillance is extremely important. Accurate characterization of novel variants with possibly increased virulence and epidemic potential are also critical. We are pleased to invite you to submit articles describing and discussing the latest data on the viral infection on swine pathogenesis, diagnosis and control. It will be useful for the determination of potential antiviral therapies within viral genomes, as well as for designing and developing novel vaccines.

Dr. Liwei Li
Guest Editor

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Keywords

  • swine virus infection
  • variability
  • virulence
  • monoclonal antibody
  • diagnosis
  • surveillance
  • epidemiology
  • therapy
  • vaccine

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Published Papers (1 paper)

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Research

24 pages, 18933 KiB  
Article
Hesperetin Inhibits Porcine Reproductive and Respiratory Syndrome Virus Replication by Downregulating the P38/JUN/FOS Pathway In Vitro
by Ruiheng Gu, Feike Zhao, Quanying Li, Limin Hou, Guochang Liu, Xueyan Sun, Junyuan Du and Binghu Fang
Microorganisms 2025, 13(2), 450; https://doi.org/10.3390/microorganisms13020450 - 18 Feb 2025
Viewed by 450
Abstract
Porcine reproductive and respiratory syndrome virus (PRRSV) is a persistent pathogen that causes significant economic losses to the global swine industry. Commercial vaccines provide only partial protection, and no effective therapeutic treatments are currently available. In this study, we demonstrate that hesperetin (Hst), [...] Read more.
Porcine reproductive and respiratory syndrome virus (PRRSV) is a persistent pathogen that causes significant economic losses to the global swine industry. Commercial vaccines provide only partial protection, and no effective therapeutic treatments are currently available. In this study, we demonstrate that hesperetin (Hst), a flavonoid glycoside derived from orange and tangerine peels, inhibits PRRSV replication in a dose-dependent manner in Marc-145 and PAMs cells. Transcriptome analysis further reveals that the anti-PRRSV effects of Hst are associated with the suppression of the P38 MAPK pathway, as Hst significantly downregulates key genes, including NRA41, JUN, FOS, and DUSP1. Subsequent investigations show that Hst inhibits PRRSV replication by downregulating the P38/JUN/FOS signaling cascade. These findings offer valuable insights for the development of novel preventive and therapeutic strategies against PRRSV infection. Full article
(This article belongs to the Special Issue Viral Infection on Swine: Pathogenesis, Diagnosis and Control)
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