Cell Signaling Transduction in Cyanobacteria

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Molecular Microbiology and Immunology".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 2277

Special Issue Editors


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Guest Editor
Interfaculty Institute of Microbiology and Infection Medicine, Eberhard Karls Universität Tübingen, 72074 Tübingen, Germany
Interests: signaling pathway; sensing; metabolic regulation; second messenger; cascade; transduction; posttranslational modification; phosphorylation

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Guest Editor
Interfaculty Institute of Microbiology and Infection Medicine, Eberhard Karls Universität Tübingen, 72074 Tübingen, Germany
Interests: cell signaling in cyanobacteria; molecular mechanisms of carbon/nitrogen regulations; cyanobacterial carbon concentrating mechanisms; PII and PII-like signal transduction proteins; developmental and structural biology
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Special Issue Information

Dear Colleagues,

Cyanobacteria are ancient organisms that inhabit all types of ecosystems and have developed complex strategies to adapt to an ever-changing environment. Adaptation responses often begin with the perception of extracellular stimuli, triggering signaling cascades, which in turn lead to changes in the transcriptome, proteome, and metabolome. These changes regulate different cellular processes that ultimately allow microorganisms to adjust to environmental changes. In recent years, our knowledge of cyanobacterial signal transduction systems has increased tremendously through the application of different omics technologies, as well as advanced microscopic technics. Protein function and structural analysis have revealed the great potential of the metabolic and cellular adaptation mechanisms of cyanobacteria towards external signals, uncovering how they perceive and transduce stimuli.

As the guest editors of this Special Issue of Microorganisms, Sofía Doello and Khaled Selim invite researchers from around the world to share their advances in the understanding of the regulatory networks controlling cyanobacterial cellular physiology. This includes original research and review articles concerning the role of second messengers, transcriptional regulators, sensing and regulatory proteins, and protein post-translational modifications (e.g., phosphorylation) in signal transduction and metabolic control.

We look forward to receiving your contributions.

Dr. Sofía Doello
Dr. Khaled Selim
Guest Editors

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Keywords

  • signaling pathway
  • sensing
  • metabolic regulation
  • second messenger
  • cascade
  • transduction
  • post-translational modification
  • phosphorylation

Published Papers (1 paper)

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Research

15 pages, 1870 KiB  
Article
The Signal Transduction Protein PII Controls the Levels of the Cyanobacterial Protein PipX
by Antonio Llop, Lorena Tremiño, Raquel Cantos and Asunción Contreras
Microorganisms 2023, 11(10), 2379; https://doi.org/10.3390/microorganisms11102379 - 23 Sep 2023
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Abstract
Cyanobacteria, microorganisms performing oxygenic photosynthesis, must adapt their metabolic processes to environmental challenges such as day and night changes. PipX, a unique regulatory protein from cyanobacteria, provides a mechanistic link between the signalling protein PII, a widely conserved (in bacteria and plants) transducer [...] Read more.
Cyanobacteria, microorganisms performing oxygenic photosynthesis, must adapt their metabolic processes to environmental challenges such as day and night changes. PipX, a unique regulatory protein from cyanobacteria, provides a mechanistic link between the signalling protein PII, a widely conserved (in bacteria and plants) transducer of carbon/nitrogen/energy richness, and the transcriptional regulator NtcA, which controls a large regulon involved in nitrogen assimilation. PipX is also involved in translational regulation through interaction with the ribosome-assembly GTPase EngA. However, increases in the PipX/PII ratio are toxic, presumably due to the abnormally increased binding of PipX to other partner(s). Here, we present mutational and structural analyses of reported PipX-PII and PipX-NtcA complexes, leading to the identification of single amino acid changes that decrease or abolish PipX toxicity. Notably, 4 out of 11 mutations decreasing toxicity did not decrease PipX levels, suggesting that the targeted residues (F12, D23, L36, and R54) provide toxicity determinants. In addition, one of those four mutations (D23A) argued against the over-activation of NtcA as the cause of PipX toxicity. Most mutations at residues contacting PII decreased PipX levels, indicating that PipX stability would depend on its ability to bind to PII, a conclusion supported by the light-induced decrease of PipX levels in Synechococcus elongatus PCC7942 (hereafter S. elongatus). Full article
(This article belongs to the Special Issue Cell Signaling Transduction in Cyanobacteria)
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