Exploring the Gut–Brain Axis in Dementia: Biomarkers, Microbiota, and Machine Learning Approaches

Dear Colleagues,

Dementia, a leading cause of disability worldwide, has been increasingly linked to dysbiosis of the gut microbiota and systemic inflammation. Emerging evidence suggests that gut-brain axis interactions play a crucial role in neurodegenerative processes, offering potential avenues for early diagnosis and intervention. This Special Issue aims to gather cutting-edge research on the interplay between gut microbiota, biomarkers, and dementia, with a focus on innovative machine learning (ML) approaches to analyze complex datasets and predict disease progression.

We invite original research articles, reviews, and methodological papers addressing, but not limited to, the following topics:

1. Gut microbiota alterations in Alzheimer’s disease and other dementias
2. Novel biomarkers (e.g., microbial metabolites, inflammatory markers, genetic/epigenetic signatures) for early detection
3. Machine learning and AI-driven models for dementia prediction using multi-omics data
4. Therapeutic interventions targeting the gut microbiome (e.g., probiotics, prebiotics, fecal transplants)
5. Integrative analyses of microbiome, metabolome, and clinical data

Dr. Bing-Mu Hsu
Guest Editor

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