Gastrointestinal Microbiota Impacts Human Health and Disease 2.0

Dear Colleagues,

This Special Issue is a continuation of our 2019 Special Issue "Gastrointestinal Microbiota Impacts Human Health and Disease".

A huge abundance and diversity of microorganisms that colonize different regions of the human gastrointestinal tract participate in a range of metabolic activities and influence many aspects of health and disease. They play an important role in maintaining immune homeostasis, assist in energy harvest from non-digestible dietary components through fermentation in the large intestine and generate many bioactive metabolites, such as short-chain fatty acids. Equally, dysbiosis is associated with a number of diseases including inflammatory bowel disease, diabetes mellitus, obesity and metabolic syndrome. Gut microbiome research has been revolutionised over the past decade through the development of culture-independent, high-throughput, next-generation DNA sequencing technology. We are developing a much better understanding of the composition of microbial communities of the healthy human gut, defining dominant members. The application of multiple omic technologies such metabolomics, proteomics, and transcriptomics has further enhanced our ability to decipher the function of the human gut microbiome including its interaction with the human host and impact on health. It is now well known that diet is one of the major influencers of both the short- and long-term composition of the human gut microbiome. Dietary manipulation of the gut microbiome therefore offers an attractive approach to achieve favourable health outcomes.

Dr. Pramod Gopal
Guest Editor

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