Special Issue "Nanomaterials for Medical Application"

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Advanced Nanomaterials and Nanotechnology".

Deadline for manuscript submissions: 31 December 2020.

Special Issue Editor

Prof. Dr. Anton Ficai
Website
Guest Editor
Department of Science and Engineering of Oxide Materials and Nanomaterials, University Politehnica of Bucharest, 011061 Bucharest, Romania
Academy of Romanian Scientists, Ilfov St no 3, Bucharest, Romania
Interests: biomaterials; nanomaterials; synthesis methods; materials processing and design; tissue engineering; drug delivery; characterization methods
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Special Issue Information

Dear Colleagues,

Many advances in the field of medicine are strongly corelated with the use of nanomaterials thus, an important topic/science is establishing namely, NANOMEDICINE. Nowadays, Nanomaterials are exploited in many applications such as diagnosis and treatment, as they are able to induce antimicrobial, antitumoral activity, and hyperthermia or can assure internalisation or targeting capabilities, can act as a smart carrier of a wide range of biologically active agents, etc.

Manuscripts dealing with nanomaterials belonging to the following classes are especially welcome: Metal and oxide nanoparticles, micro and mesoporous materials, carbonaceous materials, phosphates, etc. Topics relating to composite materials designed and manufactured by modern additive manufacturing methods for tissue engineering are also welcome. 3D-printing, electrospinning and electrospraying, atomic layer deposition (ALD), spin coating, matrix-assisted pulsed laser evaporation (MAPLE), and pulsed-laser deposition (PLD) are only some of the processing techniques which are able to generate nanomaterials with 0D, 1D, 2D, or even 3D structures. Short-, medium-, and long-term (nano)toxicity, multifunctionality, and personalized therapy are essential aspects of the modern medicine thus, manuscripts dealing with any or more such aspects will be encouraged.

Prof. Anton Ficai
Guest Editor

Manuscript Submission Information

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Keywords

  • Tissue engineering
  • Smart drug delivery
  • Materials processing and design
  • Surface physic and chemistry
  • Nanotoxicity at short/long-term
  • Risks and opportunities

Published Papers (2 papers)

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Research

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Open AccessArticle
Nano/Micro Hierarchical Bioceramic Coatings for Bone Implant Surface Treatments
Materials 2020, 13(7), 1548; https://doi.org/10.3390/ma13071548 - 27 Mar 2020
Abstract
Bone implants with surface modifications that promote the physiological activities of osteoblasts are the first step for osseointegration in bone repair. Hydroxyapatite is the main inorganic component in mammal bones and teeth, and nanoscaled hydroxyapatite promotes the adhesion of osteoblastic cells. In this [...] Read more.
Bone implants with surface modifications that promote the physiological activities of osteoblasts are the first step for osseointegration in bone repair. Hydroxyapatite is the main inorganic component in mammal bones and teeth, and nanoscaled hydroxyapatite promotes the adhesion of osteoblastic cells. In this study, we created a nano/micro hierarchical structure using micro-arc oxidation coatings and hydrothermal treatments at 150 °C, 175 °C, and 200 °C for 2, 6, 12, and 24 h. After undergoing hydrothermal treatment for 24 h, CaTiO3 began forming regular-shaped crystals at the surface at 175 °C. In order to decrease the CaTiO3 formations and increase the apatite fabrication, a shorter time of hydrothermal treatment was required at 175 °C. There was still surface damage on samples treated for 6 h at 175 °C; however, the nano/micro hierarchical structures were formed in 2 h at 175 °C. The normalized alkaline phosphatase (ALP) activities of the MC3T3-E1 cells with micro-arc oxidation (MAO) coatings and nano/micro hierarchical bioceramics coatings were 4.51 ± 0.26 and 7.36 ± 0.51 μmol p-NP/mg protein (*** P value of <0.001), respectively. The MC3T3-E1 cells with coatings showed highly statistically significant results in terms of the ALP activity. This proposed nano/micro hierarchical structure promoted cell proliferation and osteogenic differentiation of the osteoblast MC3T3-E1 cells. This study realized a promising nano system for osseointegration via bone implant surface treatments, which can promote the physiological activities of osteoblasts. Full article
(This article belongs to the Special Issue Nanomaterials for Medical Application)
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Review

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Open AccessReview
Phytosynthesized Metallic Nanoparticles—between Nanomedicine and Toxicology. A Brief Review of 2019′s Findings
Materials 2020, 13(3), 574; https://doi.org/10.3390/ma13030574 - 25 Jan 2020
Cited by 1
Abstract
Phytosynthesized nanoparticles represent a continuously increasing field of research, with numerous studies published each year. However, with the emerging interest in this area, the quality of the published works is also continuously increasing, switching from routine antioxidant or antimicrobial studies on trivial microbial [...] Read more.
Phytosynthesized nanoparticles represent a continuously increasing field of research, with numerous studies published each year. However, with the emerging interest in this area, the quality of the published works is also continuously increasing, switching from routine antioxidant or antimicrobial studies on trivial microbial lines to antibiotic-resistant strains or antitumoral studies. However, this increasing interest has not been not reflected in the studies regarding the toxicological effects of nanoparticles (NPs); this should be a subject of greatest interest, as the increasing administration of NPs in general (and phytosynthesized NPs in particular) could lead to their accumulation in the environment (soil, water and living organisms). The present review aims to present the most recent findings in the application of phytosynthesized NPs as antimicrobial and antitumoral agents, as well as the results regarding their toxicological potential. Full article
(This article belongs to the Special Issue Nanomaterials for Medical Application)
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