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Open AccessFeature PaperArticle

Nanomagnetite-embedded PLGA Spheres for Multipurpose Medical Applications

Lasers Department, National Institute for Lasers, Plasma, and Radiation Physics, 077125 Magurele, Romania
Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, 011061 Bucharest, Romania
Microbiology & Immunology Department, Faculty of Biology, University of Bucharest, 77206 Bucharest, Romania
Ligand-Receptor Interactions Department, Institute of Biochemistry, Romanian Academy, 060031 Bucharest, Romania
Authors to whom correspondence should be addressed.
Materials 2019, 12(16), 2521;
Received: 6 July 2019 / Revised: 3 August 2019 / Accepted: 5 August 2019 / Published: 8 August 2019
(This article belongs to the Special Issue Novel Materials for Antimicrobial Application)
We report on the synthesis and evaluation of biopolymeric spheres of poly(lactide-co-glycolide) containing different amounts of magnetite nanoparticles and Ibuprofen (PLGA-Fe3O4-IBUP), but also chitosan (PLGA-CS-Fe3O4-IBUP), to be considered as drug delivery systems. Besides morphological, structural, and compositional characterizations, the PLGA-Fe3O4-IBUP composite microspheres were subjected to drug release studies, performed both under biomimetically-simulated dynamic conditions and under external radiofrequency magnetic fields. The experimental data resulted by performing the drug release studies evidenced that PLGA-Fe3O4-IBUP microspheres with the lowest contents of Fe3O4 nanoparticles are optimal candidates for triggered drug release under external stimulation related to hyperthermia effect. The as-selected microspheres and their chitosan-containing counterparts were biologically assessed on macrophage cultures, being evaluated as biocompatible and bioactive materials that are able to promote cellular adhesion and proliferation. The composite biopolymeric spheres resulted in inhibited microbial growth and biofilm formation, as assessed against Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans microbial strains. Significantly improved antimicrobial effects were reported in the case of chitosan-containing biomaterials, regardless of the microorganisms’ type. The nanostructured composite biopolymeric spheres evidenced proper characteristics as prolonged and controlled drug release platforms for multipurpose biomedical applications. View Full-Text
Keywords: magnetic nanoparticles; biopolymeric spheres; hyperthermia; antimicrobial materials; multifunctional materials magnetic nanoparticles; biopolymeric spheres; hyperthermia; antimicrobial materials; multifunctional materials
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MDPI and ACS Style

Grumezescu, V.; Gherasim, O.; Negut, I.; Banita, S.; Holban, A.M.; Florian, P.; Icriverzi, M.; Socol, G. Nanomagnetite-embedded PLGA Spheres for Multipurpose Medical Applications. Materials 2019, 12, 2521.

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