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Antimicrobial Wound Dressings as Potential Materials for Skin Tissue Regeneration

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Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, 060042 Bucharest, Romania
2
National Centre for Micro and Nanomaterials, Politehnica University of Bucharest, 060042 Bucharest, Romania
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National Research Center for Food Safety, Politehnica University of Bucharest, 060042 Bucharest, Romania
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Microbiology Immunology Department, Faculty of Biology, University of Bucharest, 050095 Bucharest, Romania
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Faculty of Veterinary Medicine, University of Agronomic Science and Veterinary Medicine, 011464 Bucharest, Romania
*
Author to whom correspondence should be addressed.
Materials 2019, 12(11), 1859; https://doi.org/10.3390/ma12111859
Received: 20 March 2019 / Revised: 14 May 2019 / Accepted: 4 June 2019 / Published: 8 June 2019
(This article belongs to the Special Issue Novel Materials for Antimicrobial Application)
The most important properties of performant wound dressings are biocompatibility, the ability to retain large amount of exudate and to avoid complications related with persistent infection which could lead to delayed wound healing. This research aimed to obtain and characterize a new type of antimicrobial dressings, based on zinc oxide/sodium alginate/polyvinyl alcohol (PVA). Zinc oxide nanostructures, obtained with different morphology and grain size by hydrothermal and polyol methods, are used as antimicrobial agents along with sodium alginate, which is used to improve the biocompatibility of the dressing. The nanofiber dressing was obtained through the electrospinning method. Characterization techniques such as X-ray diffraction (XRD) and scanning electron microscopy (SEM) were performed to determine the structural and morphological properties of the obtained powders and composite fibers. Their antimicrobial activity was tested against Gram negative Escherichia coli (E. coli), Gram positive Staphylococcus aureus (S. aureus) bacteria and Candida albicans (C. albicans) yeast strains. The in vitro biocompatibility of the obtained composites was tested on human diploid cells. The obtained results suggest that the composite fibers based on zinc oxide and alginate are suitable for antimicrobial protection, are not toxic and may be useful for skin tissue regeneration if applied as a dressing. View Full-Text
Keywords: skin regeneration; zinc oxide nanostructures; antimicrobial properties; biocompatibility; electrospinning skin regeneration; zinc oxide nanostructures; antimicrobial properties; biocompatibility; electrospinning
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MDPI and ACS Style

Paduraru, A.; Ghitulica, C.; Trusca, R.; Surdu, V.A.; Neacsu, I.A.; Holban, A.M.; Birca, A.C.; Iordache, F.; Vasile, B.S. Antimicrobial Wound Dressings as Potential Materials for Skin Tissue Regeneration. Materials 2019, 12, 1859.

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