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Nanoparticles for Biomedical Applications: Synthesis and Fabrication

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Advanced Nanomaterials and Nanotechnology".

Deadline for manuscript submissions: closed (20 June 2023) | Viewed by 4061

Special Issue Editors


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Guest Editor
Department of Pharmaceutics, College of Pharmacy, University of Hail, Hail P.O. Box 2440, Saudi Arabia
Interests: nanotechnology; metallic nanoparticles; inorganic nanoparticles; drug delivery; clinical pathogens; antibiotic resistance

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Guest Editor
1. Department of Pharmaceutics, College of Pharmacy, University of Hail, Hail 81442, Saudi Arabia
2. Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt
Interests: nanoparticles; anticancer; cancer immunotherapy; drug delivery
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Special Issue Information

Dear Colleagues,

The current era of drug resistance has obliged researchers to shift the paradigm of drug development towards nanotechnological innovations. Nano-innovations have been explored to design, fabricate and synthesize nanoparticles for different biomedical applications. Interestingly, during the last decade, nanoparticles have been applied to confront various patho-aspects of infectious as well as non-infectious diseases. They have acted as an excellent delivery vehicle for different drug moeity without compromising their inherent therapeutic potential. In addition to acting as delivery vehicles, some nanoparticles have provided add-on advantages to synergize or maximize the therapeutic effect of the carried drug. Nano-researchers have also applied innovative approaches to perform the synthesis and subsequent modification of inorganic or organic nanoparticles by green chemistry/ chemicals. Green synthesis approaches are preferred in order to avoid the probability of imperceptible alterations in results due to residual chemicals. However, everything has its pros and cons: green synthesis approaches, specifically using herbal extracts, present a dilemma for the researchers, as they must define the exact compounds/enzymes involved in the synthesis and fabrication due to plethora of compounds in a single extract. Scientists have worked diligently to innovate the methods of synthesis and fabrication of nanoparticles to provide some effective nano-therapy or nano-diagnostic tools for the community. Still, the fate and toxicity aspects are the underexplored part for effective nanoparticles applications. The present Special Issue will cover original review and research articles pertinent to novel methods of nanoparticles synthesis and fabrication for their biomedical applications.

Dr. Syed Mohd Danish Rizvi
Dr. Amr S. Abu Lila
Guest Editors

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Keywords

  • nanoparticles synthesis and fabrication
  • biomedical applications of nanoparticles
  • nanoparticles as drug delivery tools
  • nanoparticles for diagnostic applications
  • fate and toxicity of nanoparticles

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Published Papers (2 papers)

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Research

18 pages, 6517 KiB  
Article
Linalool-Incorporated Synergistically Engineered Modified Liposomal Nanocarriers for Enhanced Transungual Delivery of Terbinafine against Onychomycosis
by Isha Gupta, Syeda Nashvia Adin, Md Abdur Rashid, Yahya Alhamhoom, Mohd. Aqil and Mohd. Mujeeb
Materials 2023, 16(12), 4424; https://doi.org/10.3390/ma16124424 - 16 Jun 2023
Cited by 6 | Viewed by 1401
Abstract
This work investigates the synthesis of linalool-containing invasomes for terbinafine (TBF-IN) in order to increase the solubility, bioavailability, and nail permeability of terbinafine (TBF) for transungual administration. TBF-IN was created utilising the thin-film hydration technique, and with the Box–Behnken design (BBD), optimisation was [...] Read more.
This work investigates the synthesis of linalool-containing invasomes for terbinafine (TBF-IN) in order to increase the solubility, bioavailability, and nail permeability of terbinafine (TBF) for transungual administration. TBF-IN was created utilising the thin-film hydration technique, and with the Box–Behnken design (BBD), optimisation was carried out. TBF-INopt were investigated for vesicle size, zeta potential, PDI (Polydispersity index), entrapment efficiency (EE) and in vitro TBF release. In addition, nail permeation analysis, TEM (transmission electron microscopy), and CLSM (confocal scanning laser microscopy) were performed for further evaluation. The TBF-INopt exhibited spherical as well as sealed vesicles with a considerably small size of 146.3 nm, an EE of 74.23 per cent, a PDI of 0.1612, and an in vitro release of 85.32 per cent. The CLSM investigation revealed that the new formulation had better TBF nail penetration than the TBF suspension gel. The antifungal investigation demonstrated that the TBF-IN gel has superior antifungal activity against Trichophyton rubrum and Candida albicans compared to the commercially available terbinafine gel. In addition, an investigation of skin irritation using Wistar albino rats indicates that the TBF-IN formulation is safe for topical treatment. This study confirmed that the invasomal vesicle formulation is an effective vehicle for the transungual delivery of TBF for the treatment of onychomycosis. Full article
(This article belongs to the Special Issue Nanoparticles for Biomedical Applications: Synthesis and Fabrication)
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13 pages, 5066 KiB  
Article
Development and Characterization of PEGDA Microneedles for Localized Drug Delivery of Gemcitabine to Treat Inflammatory Breast Cancer
by Ahmed Alafnan, Aravindram Attiguppe Seetharam, Talib Hussain, Maram Suresh Gupta, Syed Mohd Danish Rizvi, Afrasim Moin, Abdulwahab Alamri, Aziz Unnisa, Amir Mahgoub Awadelkareem, AbdElmoneim O. Elkhalifa, Pradyumna Jayahanumaiah, Mohammad Khalid and Natchimuthu Balashanmugam
Materials 2022, 15(21), 7693; https://doi.org/10.3390/ma15217693 - 1 Nov 2022
Cited by 12 | Viewed by 2098
Abstract
Inflammatory breast cancer (IBC) is one of the most belligerent types of breast cancer. While various modalities exist in managing/treating IBC, drug delivery using microneedles (MNs) is considered to be the most innovative method of localized delivery of anti-cancer agents. Localized drug delivery [...] Read more.
Inflammatory breast cancer (IBC) is one of the most belligerent types of breast cancer. While various modalities exist in managing/treating IBC, drug delivery using microneedles (MNs) is considered to be the most innovative method of localized delivery of anti-cancer agents. Localized drug delivery helps to treat IBC could limit their adverse reactions. MNs are nothing but small needle like structures that cause little or no pain at the site of administration for drug delivery via layers of the skin. The polyethylene glycol diacrylate (PEGDA) based MNs were fabricated by using three dimensional (3D) technology called Projection Micro-Stereo Lithography (PµSL). The fabricated microneedle patches (MNPs) were characterized and coated with a coating formulation comprising of gemcitabine and sodium carboxymethyl cellulose by a novel and inventive screen plate method. The drug coated MNPs were characterized by various instrumental methods of analysis and release profile studies were carried out using Franz diffusion cell. Coat-and-poke strategy was employed in administering the drug coated MNPs. Overall, the methods employed in the present study not only help in obtaining MNPs with accurate dimensions but also help in obtaining uniformly drug coated MNPs of gemcitabine for treatment of IBC. Most importantly, 100% drug release was achieved within the first one hour only. Full article
(This article belongs to the Special Issue Nanoparticles for Biomedical Applications: Synthesis and Fabrication)
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