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Advanced Nanomaterials for Biological, Medical and Environmental Applications (3rd Edition)

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Advanced Nanomaterials and Nanotechnology".

Deadline for manuscript submissions: 20 December 2025 | Viewed by 3043

Special Issue Editor

Dr. Miruna Silvia Stan

E-Mail Website
Guest Editor
Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, 050095 Bucharest, Romania
Interests: nanoparticles; photocatalysts; medical devices; oxidative stress; biomaterials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

I am pleased to invite you to submit your research papers to our upcoming Special Issue titled “Advanced Nanomaterials for Biological, Medical and Environmental Applications (3rd Edition)”. This Special Issue is being launched to highlight the latest advancements in the field of nanomaterials for biological, medical, and environmental applications.

The field of nanomaterials has shown tremendous potential in recent years, providing promising solutions to some of the most pressing challenges in the biological, medical, and environmental sectors. This Special Issue seeks to provide a platform for researchers to present their cutting-edge research in this field, with a particular focus on the application of nanomaterials to solve problems related to biology, medicine, and the environment.

Original research articles, reviews, and perspectives that address topics related to advanced nanomaterials for biological, medical, and environmental applications are all welcome. Some of the key themes we hope to cover in this Special Issue include, but are not limited to, the following:

  • Synthesis and characterization of advanced nanomaterials for biomedical applications;
  • Nanomaterials for targeted drug delivery and imaging in medicine;
  • Nano-biosensors and nanobiosystems for the detection and monitoring of biological species;
  • Nanomaterials for water treatment and remediation of environmental pollutants;
  • The impact of nanomaterials on environmental health and safety.

This Special Issue will serve as an important platform for researchers to share their latest findings and contribute to the advancements of the field. We look forward to receiving your submissions and making this Special Issue a great success.

Dr. Miruna Silvia Stan
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanobiosystems
  • synthesis
  • nanotoxicology
  • nanomedicine
  • nanotechnology

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Related Special Issues

Published Papers (4 papers)

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Research

24 pages, 2495 KiB  
Article
Application of Pure and Ion-Doped FeB, CoB, MnB, and Fe2B Nanoparticles for Magnetic Hyperthermia
by Angel T. Apostolov, Iliana N. Apostolova and Julia M. Wesselinowa
Materials 2025, 18(12), 2765; https://doi.org/10.3390/ma18122765 - 12 Jun 2025
Viewed by 301
Abstract
This study investigates Mn1−xXxB (X = Fe, Co) and (Fe1−xCox)2B nanoparticles as candidates for self-controlled magnetic hyperthermia (SCMH) in cancer therapy. Using a microscopic model and Green’s function techniques, we calculate the Curie [...] Read more.
This study investigates Mn1−xXxB (X = Fe, Co) and (Fe1−xCox)2B nanoparticles as candidates for self-controlled magnetic hyperthermia (SCMH) in cancer therapy. Using a microscopic model and Green’s function techniques, we calculate the Curie temperature, saturation magnetization, coercivity, and specific absorption rate as functions of nanoparticle size and dopant concentration. Surface and size effects are taken into account. The results are in good agreement with experimental data, confirming the model’s validity and highlighting the potential of these nanoparticles for efficient and safe magnetic hyperthermia applications. We have found that pure and doped MnB and Co2B nanoparticles with specific compositions meet biocompatibility requirements for SCMH suitable for in vivo and in vitro, for example, Mn0.6Co0.4B (d = 27.1 nm); Mn0.5Co0.5B (d = 32.2 nm); MnB (d = 26.3 m); (Fe0.2Co0.8)2B (d = 22.0 nm); (Fe0.1Co0.9)2B (d = 26.3 nm); and Co2B (d = 31.7 nm). Full article
(This article belongs to the Special Issue Advanced Nanomaterials for Biological, Medical and Environmental Applications (3rd Edition))
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13 pages, 2448 KiB  
Article
NIR-Responsive Microbubble Delivery Platforms for Controlled Drug Release in Cancer Therapy
by Kibeom Kim, Been Yoon, Jungmin Lee, Gyuri Kim and Myoung-Hwan Park
Materials 2025, 18(12), 2725; https://doi.org/10.3390/ma18122725 - 10 Jun 2025
Viewed by 439
Abstract
Cancer remains one of the leading causes of death worldwide. Therefore, the continuous development of effective therapeutic strategies is necessary. Conventional anticancer chemotherapy has low bioavailability and poor systemic distribution, resulting in serious side effects and limited therapeutic efficacy. To address these limitations, [...] Read more.
Cancer remains one of the leading causes of death worldwide. Therefore, the continuous development of effective therapeutic strategies is necessary. Conventional anticancer chemotherapy has low bioavailability and poor systemic distribution, resulting in serious side effects and limited therapeutic efficacy. To address these limitations, drug delivery systems that respond to external stimuli have been developed to release drugs at specific sites. In this study, a phase transition-based bubble-mediated emulsion system was developed to enable near-infrared (NIR)-induced drug release. This system consists of an oil phase, 2H,3H-perfluoropentane (PFC), a fluorinated liquid gas that evaporates at a certain temperature, and encapsulated IR-780 and paclitaxel to maintain stable microbubbles. Under NIR irradiation, IR-780 exhibits a photothermal conversion effect, which increases the temperature. Above the critical temperature, PFC undergoes a phase transition into gas, forming gas bubbles. This phase transition leads to a rapid volume expansion, destroys the microbubble structure, and triggers drug release. The NIR-responsive microbubble system developed in this study facilitated targeted and selective drug release through precise temperature control using the photothermal effects and phase transition. This system provides a novel platform to improve the efficacy of cancer therapies. Full article
(This article belongs to the Special Issue Advanced Nanomaterials for Biological, Medical and Environmental Applications (3rd Edition))
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19 pages, 1500 KiB  
Article
Green Design and Life Cycle Assessment of Novel Thiophene-Based Surfactants to Balance Their Synthesis Performance and Environmental Impact
by Catalina Stoica, Alina Roxana Banciu, Hisham Idriss, Justin Z. Lian, Anca-Maria Patrascu, Stefano Cucurachi, Sébastien Richeter, Sébastien Clément and Mihai Nita-Lazar
Materials 2025, 18(12), 2701; https://doi.org/10.3390/ma18122701 - 8 Jun 2025
Viewed by 775
Abstract
Continuous human population growth, industrialization, and technical progress have increased the demand for a new design and synthesis of chemical compounds. Developing eco-friendly chemical compounds has been a priority for fostering a sustainable and healthy environment, which is directly linked to human well-being. [...] Read more.
Continuous human population growth, industrialization, and technical progress have increased the demand for a new design and synthesis of chemical compounds. Developing eco-friendly chemical compounds has been a priority for fostering a sustainable and healthy environment, which is directly linked to human well-being. In this context, green chemistry and circular economy principles have been applied to generate valuable new chemicals, such as surfactants, with high market value. Surfactants play a crucial role in various products for both domestic and industrial applications, leading to their large-scale production a diverse array of chemical structures. However, the advantages of their use must be balanced against their negative environmental impact as pollutants. Thus, there is an increasing demand for the development of new eco-friendly surfactants. Additionally, life cycle assessment (LCA) studies of new surfactants are essential for evaluating their environmental impact, enhancing energy efficiency and facilitating the transition toward sustainable energy resources. In this work, we present the chemical synthesis of oligomeric and polymeric thiophene-based surfactants with potential applications in biosensors, organic transistors, and various other fields. The newly synthesized oligomeric and polymeric thiophene-based surfactants demonstrated medium-to-high biodegradation potential and showed no significant ecotoxicological effects on bacterial communities. However, the LCA of their synthesis revealed a negative impact on the environment and human health, particularly concerning polymeric thiophene-based surfactants. The LCA identified specific chemical steps that could be optimized to develop a new generation of eco-friendly surfactants. Full article
(This article belongs to the Special Issue Advanced Nanomaterials for Biological, Medical and Environmental Applications (3rd Edition))
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19 pages, 11685 KiB  
Article
Vortex-Mixing Microfluidic Fabrication of Micafungin-Loaded Magnetite–Salicylic Acid–Silica Nanocomposite with Sustained-Release Capacity
by Doina-Antonia Mercan, Adelina-Gabriela Niculescu, Alexandra Cătălina Bîrcă, Diana-Elena Cristea, Alina Moroșan, Dana-Ionela Tudorache, Bogdan Purcăreanu, Bogdan Ștefan Vasile, Dana Radu, Mihai Alexandru Grigoroscuta, Tony Hadibarata, Dan Eduard Mihaiescu and Alexandru Mihai Grumezescu
Materials 2024, 17(23), 5816; https://doi.org/10.3390/ma17235816 - 27 Nov 2024
Cited by 4 | Viewed by 1178
Abstract
Iron oxide nanoparticles were synthesized using a vortex microfluidic system and subsequently functionalized with a primary shell of salicylic acid, recognized for its ability to increase the stability and biocompatibility of coated materials. In the second stage, the vortex platform was placed in [...] Read more.
Iron oxide nanoparticles were synthesized using a vortex microfluidic system and subsequently functionalized with a primary shell of salicylic acid, recognized for its ability to increase the stability and biocompatibility of coated materials. In the second stage, the vortex platform was placed in a magnetic field to facilitate the growth and development of a porous silica shell. The selected drug for this study was micafungin, an antifungal agent well regarded for its effectiveness in combating fungal infections and identified as a priority compound by the World Health Organization (WHO). The resulting nanocomposite system was characterized using various techniques, including Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), transmission electron microscopy (TEM), dynamic light scattering (DLS), Brunauer–Emmett–Teller (BET) analysis, UV-Vis spectroscopy, and Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS). The synthesis method produced nanoparticles with dimensions of 5–7 nm, highlighting the advantages of the chosen approach. A desorption profile was established using a continuous-flow, UV-Vis analysis system, indicating that the bioactive compound was released slowly; after two hours, approximately 50% of the loaded micafungin was detected in the release medium. Furthermore, the results obtained from the FT-ICR MS analysis provided molecular-level confirmation, thereby supporting the release mechanism of micafungin from the nanosystem. Full article
(This article belongs to the Special Issue Advanced Nanomaterials for Biological, Medical and Environmental Applications (3rd Edition))
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