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Graphene and Graphene Oxide as Nanomaterials for Biomedical Application
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Graphene and Graphene Oxide as Nanomaterials for Biomedical Application

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Advanced Nanomaterials and Nanotechnology".

Deadline for manuscript submissions: closed (20 February 2024) | Viewed by 4968

Special Issue Editors

Dr. Lijun Liang

E-Mail Website
Guest Editor
College of Automation, College of Materials and Environmental Engineering, Hangzhou Dianzi University, Hangzhou 310018, China
Interests: drug delivery; multiscale modeling; artificial intelligence; material design; two-dimensional materials
Prof. Dr. Jiawei Shen

E-Mail Website
Guest Editor
College of Pharmacy, Hangzhou Normal University, Hangzhou, China
Interests: drug delivery; gene delivery biomaterials; desalination; molecular dynamics simulation; multi-scale simulation; nanopores

Special Issue Information

Dear Colleagues,

Graphene and graphene-oxide-based nanomaterials have attracted broad research interest because of their unique physiochemical properties. Both experiments and computational modeling has engaged in exploring the use of these 2D allotropic structures in various medicinal and biological fields. The biomedical applications of graphene and its composites, including in small molecular drug delivery, biosensors, bioimaging, etc., have been extensively studied in the last ten years. Moreover, the nanotoxicology of graphene and its derivatives is also of interest due to its promising applications for the biofunctionalization of protein, in anticancer therapy, and as an antimicrobial agent for bone and teeth implantation. The biocompatibility of newly synthesized nanomaterials allows their substantial use in medicine and biology. Therefore, we invite you to submit manuscripts to this Special Issue on the aforementioned topics. Full papers, communications, and reviews are all welcome.

Dr. Lijun Liang
Prof. Dr. Jiawei Shen
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • graphene
  • graphene oxide
  • drug delivery
  • biosensor
  • bioimaging
  • multiscale modeling
  • gene delivery
  • biomaterials

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Published Papers (2 papers)

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Research

14 pages, 3783 KiB  
Article
Molecular Dynamics Simulation of the Interaction between Graphene Oxide Quantum Dots and DNA Fragment
by Lingxiao Wu, Pengzhen Zhang, Hanxing Zhou, Jing Li, Xin Shen, Tianyu Li, Zhe Kong, Wei Hu and Yongjun Zhang
Materials 2022, 15(23), 8506; https://doi.org/10.3390/ma15238506 - 29 Nov 2022
Cited by 5 | Viewed by 2393
Abstract
Due to their excellent physical properties, graphene oxide quantum dots (GOQDs) are widely used in various fields, especially biomedicine. However, due to the short study period, their biosafety and potential genotoxicity to human and animal cells are not well elucidated. In this study, [...] Read more.
Due to their excellent physical properties, graphene oxide quantum dots (GOQDs) are widely used in various fields, especially biomedicine. However, due to the short study period, their biosafety and potential genotoxicity to human and animal cells are not well elucidated. In this study, the adsorption of GOQDs with different concentrations and oxidation degrees on DNA was investigated using a molecular dynamics simulation method. The toxicity to DNA depended on the interaction mechanism that GOQDs adsorbed on DNA fragments, especially in the minor groove of DNA. When the number of the adsorbed GOQDs in the minor groove of DNA is small, the GOQD inserts into the interior of the base pair. When there are more GOQDs in the minor groove of DNA, the base pairs at the adsorption sites of DNA unwind directly. This interaction way damaged the double helix structure of DNA seriously. We also compare the different functional groups of -1COOH. The results show that the interaction energy between 1COOH-GQD and DNA is stronger than that between 1OH-GQD and DNA. However, the damage to DNA is the opposite. These findings deepen our understanding of graphene nanotoxicity in general. Full article
(This article belongs to the Special Issue Graphene and Graphene Oxide as Nanomaterials for Biomedical Application)
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16 pages, 4784 KiB  
Article
Theoretical Evaluation of Potential Cytotoxicity of Graphene Quantum Dot to Adsorbed DNA
by Lijun Liang, Xin Shen, Mengdi Zhou, Yijian Chen, Xudong Lu, Li Zhang, Wei Wang and Jia-Wei Shen
Materials 2022, 15(21), 7435; https://doi.org/10.3390/ma15217435 - 23 Oct 2022
Cited by 1 | Viewed by 1784
Abstract
As a zero-dimensional (0D) nanomaterial, graphene quantum dot (GQD) has a unique physical structure and electrochemical properties, which has been widely used in biomedical fields, such as bioimaging, biosensor, drug delivery, etc. Its biological safety and potential cytotoxicity to human and animal cells [...] Read more.
As a zero-dimensional (0D) nanomaterial, graphene quantum dot (GQD) has a unique physical structure and electrochemical properties, which has been widely used in biomedical fields, such as bioimaging, biosensor, drug delivery, etc. Its biological safety and potential cytotoxicity to human and animal cells have become a growing concern in recent years. In particular, the potential DNA structure damage caused by GQD is of great importance but still obscure. In this study, molecular dynamics (MD) simulation was used to investigate the adsorption behavior and the structural changes of single-stranded (ssDNA) and double-stranded DNA (dsDNA) on the surfaces of GQDs with different sizes and oxidation. Our results showed that ssDNA can strongly adsorb and lay flat on the surface of GQDs and graphene oxide quantum dots (GOQDs), whereas dsDNA was preferentially oriented vertically on both surfaces. With the increase of GQDs size, more structural change of adsorbed ssDNA and dsDNA could be found, while the size effect of GOQD on the structure of ssDNA and dsDNA is not significant. These findings may help to improve the understanding of GQD biocompatibility and potential applications of GQD in the biomedical field. Full article
(This article belongs to the Special Issue Graphene and Graphene Oxide as Nanomaterials for Biomedical Application)
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