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Marine Drugs
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Selected Papers from the 9th European Conference on Marine Natural...
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Selected Papers from the 9th European Conference on Marine Natural Products

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: closed (30 November 2015) | Viewed by 31095

Special Issue Editors

Prof. Dr. Marcel Jaspars

E-Mail Website
Guest Editor
Marine Biodiscovery Centre, University of Aberdeen, Aberdeen, UK
Interests: marine natural products; structure determination; nuclear magnetic resonance spectroscopy; mass spectrometry; ocean policy
Special Issues, Collections and Topics in MDPI journals
Dr. RuAngelie Edrada-Ebel

E-Mail Website
Guest Editor
Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK
Interests: marine natural products chemistry; secondary metabolomics; NMR- and MS-based metabolomics; marine biotechnology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The 9th European Conference on Marine Natural Products: The Sea as a Sustainable Source of New Medicine and Renewable Energy.

Marine Natural Products Research has become diverse, not only in terms of its application, but as well as the development of innovative technology to exploit these resources. In addition to the traditional fields of isolation and structure elucidation, synthesis, and biological activity of marine natural products, new methods of dereplication involving metabolomics and innovative perspectives in marine industrial biotechnology are evolving.

The 9th European Marine Natural Products Conference will be held in Glasgow, Scotland, 30 August – 2 September 2015 at the newly built Technical Innovation Centre (TIC) at the University of Strathclyde. This conference is jointly organized by four Scottish Universities: the University of Strathclyde, the University of Aberdeen, Heriot-Watt University, and the University of Highlands and Islands; three EU consortia: SeaBioTech, PharmaSea, and BlueGenics, along with the Phytochemical Society of Europe.

The conference is organised in ten different sessions:

  • Chemical Ecology
  • Deep Sea and Polar Research
  • Marine Toxins and Bioassays
  • Dereplication, Metabolomics, and Rational approaches to Bioprospecting
  • Isolation and Structure Elucidation
  • Industrial Biotechnology, Polymers and Biomolecules
  • Organic Synthesis
  • Biosynthesis of Marine Natural Products in Microbes
  • Marine Microbes/Fungi
  • Marine Policy

We are expecting around 250 international participants. To extend the impact of this conference to the Marine Bioprospecting and Biodiscovery community, the scientific committee is organising a Special Issue of Marine Drugs dedicated to this symposium entitled "Selected Papers from the 9th European Conference on Marine Natural Products (ECMNP2015)". We kindly invite the attendees to participate in this Special Issue.

Web Site: http://ecmnp2015.com/

Dr. RuAngelie Edrada-Ebel
Prof. Marcel Jaspars
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (3 papers)

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397 KiB  
Article
Antimicrobial Activity of Monoramnholipids Produced by Bacterial Strains Isolated from the Ross Sea (Antarctica)
by Pietro Tedesco, Isabel Maida, Fortunato Palma Esposito, Emiliana Tortorella, Karolina Subko, Chidinma Christiana Ezeofor, Ying Zhang, Jioji Tabudravu, Marcel Jaspars, Renato Fani and Donatella De Pascale
Mar. Drugs 2016, 14(5), 83; https://doi.org/10.3390/md14050083 - 26 Apr 2016
Cited by 50 | Viewed by 9508
Abstract
Microorganisms living in extreme environments represent a huge reservoir of novel antimicrobial compounds and possibly of novel chemical families. Antarctica is one of the most extraordinary places on Earth and exhibits many distinctive features. Antarctic microorganisms are well known producers of valuable secondary [...] Read more.
Microorganisms living in extreme environments represent a huge reservoir of novel antimicrobial compounds and possibly of novel chemical families. Antarctica is one of the most extraordinary places on Earth and exhibits many distinctive features. Antarctic microorganisms are well known producers of valuable secondary metabolites. Specifically, several Antarctic strains have been reported to inhibit opportunistic human pathogens strains belonging to Burkholderia cepacia complex (Bcc). Herein, we applied a biodiscovery pipeline for the identification of anti-Bcc compounds. Antarctic sub-sea sediments were collected from the Ross Sea, and used to isolate 25 microorganisms, which were phylogenetically affiliated to three bacterial genera (Psychrobacter, Arthrobacter, and Pseudomonas) via sequencing and analysis of 16S rRNA genes. They were then subjected to a primary cell-based screening to determine their bioactivity against Bcc strains. Positive isolates were used to produce crude extracts from microbial spent culture media, to perform the secondary screening. Strain Pseudomonas BNT1 was then selected for bioassay-guided purification employing SPE and HPLC. Finally, LC-MS and NMR structurally resolved the purified bioactive compounds. With this strategy, we achieved the isolation of three rhamnolipids, two of which were new, endowed with high (MIC < 1 μg/mL) and unreported antimicrobial activity against Bcc strains. Full article
(This article belongs to the Special Issue Selected Papers from the 9th European Conference on Marine Natural Products)
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1636 KiB  
Article
The Bacterial (Vibrio alginolyticus) Production of Tetrodotoxin in the Ribbon Worm Lineus longissimus—Just a False Positive?
by Malin Strand, Martin Hedström, Henrik Seth, Eric G. McEvoy, Erik Jacobsson, Ulf Göransson, Håkan S. Andersson and Per Sundberg
Mar. Drugs 2016, 14(4), 63; https://doi.org/10.3390/md14040063 - 25 Mar 2016
Cited by 22 | Viewed by 9507
Abstract
We test previous claims that the bacteria Vibrio alginolyticus produces tetrodotoxin (TTX) when living in symbiosis with the nemertean Lineus longissimus by a setup with bacteria cultivation for TTX production. Toxicity experiments on the shore crab, Carcinus maenas, demonstrated the presence of [...] Read more.
We test previous claims that the bacteria Vibrio alginolyticus produces tetrodotoxin (TTX) when living in symbiosis with the nemertean Lineus longissimus by a setup with bacteria cultivation for TTX production. Toxicity experiments on the shore crab, Carcinus maenas, demonstrated the presence of a paralytic toxin, but evidence from LC-MS and electrophysiological measurements of voltage-gated sodium channel–dependent nerve conductance in male Wistar rat tissue showed conclusively that this effect did not originate from TTX. However, a compound of similar molecular weight was found, albeit apparently non-toxic, and with different LC retention time and MS/MS fragmentation pattern than those of TTX. We conclude that C. maenas paralysis and death likely emanate from a compound <5 kDa, and via a different mechanism of action than that of TTX. The similarity in mass between TTX and the Vibrio-produced low-molecular-weight, non-toxic compound invokes that thorough analysis is required when assessing TTX production. Based on our findings, we suggest that re-examination of some published claims of TTX production may be warranted. Full article
(This article belongs to the Special Issue Selected Papers from the 9th European Conference on Marine Natural Products)
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1261 KiB  
Conference Report
The 9th European Conference on Marine Natural Products
by RuAngelie Edrada-Ebel and Marcel Jaspars
Mar. Drugs 2015, 13(12), 7150-7249; https://doi.org/10.3390/md13127059 - 3 Dec 2015
Cited by 5 | Viewed by 11347
Abstract
The 9th European Conference on Marine Natural Products (ECMNP) in Glasgow follows its predecessors in La Toja (2013), Tjärnö (2011), Porto (2009), Ischia (2007), Paris (2005), Elmau (2002), Santiago de Compostela (1999), and Athens (1997). [...] Full article
(This article belongs to the Special Issue Selected Papers from the 9th European Conference on Marine Natural Products)
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