Research on Marine Compounds and Inflammation

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine Pharmacology".

Deadline for manuscript submissions: 1 October 2025 | Viewed by 257

Special Issue Editor


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Guest Editor
Department of Biotechnology, Chemistry & Pharmacy, University of Siena, Via A. Moro, 53100 Siena, Italy
Interests: bioeconomy; sustainability; marine plants; macroalgae; rare diseases; inflammation; post-genomics; omics
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Special Issue Information

Dear Colleagues,

Although inflammation is an essential biological response to harmful stimuli, chronic inflammation is connected to numerous diseases, such as cancer, neurodegenerative disorders, and autoimmune conditions. Marine ecosystems are a source of bioactive compounds that have potential anti-inflammatory effects that have not yet been explored. The aim of this Special Issue is to highlight the most recent developments in the discovery, characterization, and mechanisms of action of marine-derived anti-inflammatory agents. We welcome original research and review articles focusing on the identification of novel compounds from marine organisms, their biosynthetic pathways, and their molecular targets in inflammatory processes. Studies employing in vitro, in vivo, and omics approaches to elucidate the potential of these compounds are particularly encouraged. Our goal is to bring together cutting-edge research in this field to promote new perspectives on marine natural products as sustainable and effective remedies for inflammation-related diseases.

Dr. Michela Geminiani
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • anti-inflammatory compounds
  • marine bioactive metabolites
  • inflammation
  • bioactive secondary metabolites
  • molecular targets of inflammation
  • marine algae
  • inflammatory pathways

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Published Papers (1 paper)

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21 pages, 2879 KiB  
Article
Undaria pinnatifida Fucoidan Enhances Gut Microbiome, Butyrate Production, and Exerts Anti-Inflammatory Effects in an In Vitro Short-Term SHIME® Coupled to a Caco-2/THP-1 Co-Culture Model
by Barbara C. Wimmer, Corinna Dwan, Jelle De Medts, Cindy Duysburgh, Chloë Rotsaert and Massimo Marzorati
Mar. Drugs 2025, 23(6), 242; https://doi.org/10.3390/md23060242 - 4 Jun 2025
Viewed by 134
Abstract
Fucoidans have demonstrated a wide range of bioactivities including immune modulation and benefits in gut health. To gain a deeper understanding on the effects of fucoidan from Undaria pinnatifida (UPF) on the colonic microbiome, the short-term Simulator of the Human Intestinal Microbial Ecosystem [...] Read more.
Fucoidans have demonstrated a wide range of bioactivities including immune modulation and benefits in gut health. To gain a deeper understanding on the effects of fucoidan from Undaria pinnatifida (UPF) on the colonic microbiome, the short-term Simulator of the Human Intestinal Microbial Ecosystem®, a validated in vitro gut model, was applied. Following a three-week intervention period on adult faecal samples from three healthy donors, microbial community activity of the colonic microbiota was assessed by quantifying short-chain fatty acids while composition was analysed utilising 16S-targeted Illumina sequencing. Metagenomic data were used to describe changes in community structure. To assess the secretion of cytokines, co-culture experiments using Caco-2 and THP1-Blue™ cells were performed. UPF supplementation over a three-week period had a profound butyrogenic effect while also enriching colonic microbial diversity, consistently stimulating saccharolytic genera, and reducing genera linked with potentially negative health effects in both regions of the colon. Mild immune modulatory effects of UPF were also observed. Colonic fermentation of UPF showed anti-inflammatory properties by inducing the secretion of the anti-inflammatory cytokines IL-6 and IL-10 in two out of three donors in the proximal and distal colon. In conclusion, UPF supplementation may provide significant gut health benefits. Full article
(This article belongs to the Special Issue Research on Marine Compounds and Inflammation)
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