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Magnetochemistry
Special Issues
Transition-Metal Contrast Agents for MRI
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Transition-Metal Contrast Agents for MRI

A special issue of Magnetochemistry (ISSN 2312-7481). This special issue belongs to the section "Magnetic Resonances".

Deadline for manuscript submissions: closed (31 October 2021) | Viewed by 4620
Related Special Issue: Transition-Metal Contrast Agents for MRI

Special Issue Editors

Dr. Nicola J. Rogers

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Guest Editor
Department of Chemistry, University of Warwick, Coventry, UK
Interests: molecular imaging probes and therapeutics
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Janet R. Morrow

E-Mail Website
Guest Editor
Department of Chemistry, University at Buffalo, the State University of New York, Buffalo, NY 14260, USA
Interests: bioinorganic chemistry; bimodal imaging agents; MRI contrast agents based on transition metal complexes; ligand synthesis; structure selective interactions of compounds with DNA and RNA; magnetic properties of complexes and particles
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

MRI contrast agents are routinely used in MRI examinations for diagnosis in the clinic and are essential to modern diagnostic techniques. By far, the majority of these agents are coordination complexes of Gd(III), which exhibit high magnetic susceptibility and impart contrast by enhancing the relaxation rate of surrounding water protons. However, growing safety concerns over the use of lanthanide-based contrast agents has led the drive to find alternatives to gadolinium-based MRI agents due to links with nephrogenic systemic fibrosis and reports of Gd(III) retention in the brains and bone of patients receiving multiple doses.

One approach is to look to endogenous transition metal ions as alternatives. Several strategies can be used to achieve contrast in proton MRI using transition metal ions, including conventional relaxivity agents, which exploit paramagnetic relaxation enhancement, and paraSHIFT agents, for which paramagnetic hyperfine shifts are induced by anisotropic magnetic susceptibility. Spin changes can be induced with an external stimulus using transition metal chemistry in pursuit of switchable contrast agents for imaging biochemical processes. This Special Issue of Magnetochemistry aims to publish a collection of research contributions of recent work in the development, study, and understanding of transition metal contrast agents for MRI.

You may choose our Joint Special Issue in Applied Sciences.

Dr. Nicola J. Rogers
Prof. Dr. Janet R. Morrow
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Magnetochemistry is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • magnetic resonance imaging
  • contrast agents
  • relaxivity
  • paraSHIFT
  • paraCEST
  • transition metal ions

Published Papers (1 paper)

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Research

20 pages, 3579 KiB  
Article
Saccharomyces cerevisiae and Candida albicans Yeast Cells Labeled with Fe(III) Complexes as MRI Probes
by Akanksha Patel, Didar Asik, Eric M. Snyder, Joseph A. Spernyak, Paul J. Cullen and Janet R. Morrow
Magnetochemistry 2020, 6(3), 41; https://doi.org/10.3390/magnetochemistry6030041 - 04 Sep 2020
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Abstract
The development of MRI probes is of interest for labeling antibiotic-resistant fungal infections based on yeast. Our work showed that yeast cells can be labeled with high-spin Fe(III) complexes to produce enhanced T2 water proton relaxation. These Fe(III)-based macrocyclic complexes contained a [...] Read more.
The development of MRI probes is of interest for labeling antibiotic-resistant fungal infections based on yeast. Our work showed that yeast cells can be labeled with high-spin Fe(III) complexes to produce enhanced T2 water proton relaxation. These Fe(III)-based macrocyclic complexes contained a 1,4,7-triazacyclononane framework, two pendant alcohol groups, and either a non-coordinating ancillary group and a bound water molecule or a third coordinating pendant. The Fe(III) complexes that had an open coordination site associated strongly with Saccharomyces cerevisiae upon incubation, as shown by screening using Z-spectra analysis. The incubation of one Fe(III) complex with either Saccharomyces cerevisiae or Candida albicans yeast led to an interaction with the β-glucan-based cell wall, as shown by the ready retrieval of the complex by the bidentate chelator called maltol. Other conditions, such as a heat shock treatment of the complexes, produced Fe(III) complex uptake that could not be reversed by the addition of maltol. Appending a fluorescence dye to Fe(TOB) led to uptake through secretory pathways, as shown by confocal fluorescence microscopy and by the incomplete retrieval of the Fe(III) complex by the maltol treatment. Yeast cells that were labeled with these Fe(III) complexes displayed enhanced water proton T2 relaxation, both for S. cerevisiae and for yeast and hyphal forms of C. albicans. Full article
(This article belongs to the Special Issue Transition-Metal Contrast Agents for MRI)
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