New Insights into the Treatment of Colorectal Cancer in the Era of Precision Medicine

Dear Colleagues,

During the last 20 years, we have observed a dramatic revolution in the therapeutic scenario of patients with colorectal cancer (CRC), with a shift from single-agent chemotherapy drugs to personalized medicine.

This change has been possible thanks to increased knowledge of the molecular biology of CRC, leading to the clinical development of tailored therapies.  Unfortunately, not all patients with CRC harboring a driver gene alteration respond to target therapy. Therefore, major efforts are needed to increase understanding of tumor heterogeneity, identify predictive biomarkers of response, find new combinatory strategies and improve patient outcomes.

Thus, the aim of this Special Issue of Life is to summarize the novel advances in CRC research that could lead to the optimization of patient selection and, therefore, to more effective treatments.

We encourage the submission of original research, reviews as well as high-quality case reports related to the latest progress on the theme topic.

Dr. Davide Ciardiello
Dr. Alessandro Parisi
Guest Editors

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