Cross-Talk between Mitochondria and Proteasomes in Diseases
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".
Deadline for manuscript submissions: closed (15 September 2021) | Viewed by 11168
Special Issue Editor
Interests: ageing; proteasome; neurodegenerative diseases; life span in yeast
Special Issue Information
Dear Colleagues,
Proteasome activity and mitochondrial homeostasis came to the front line of biomedical research due to their involvement and impairment in many diseases, including neurodegenerative and cardiovascular diseases. The ubiquitin-proteasome system (UPS) and autophagy play a crucial role in the maintenance of protein homeostasis through their ability to eliminate damaged and misfolded proteins. Their activities are vital for numerous cellular processes that are regulated by the temporally specific degradation of pathway components. In most eukaryotic cells, mitochondria form a dynamic network and are subject to continuous fission and fusion. Unopposed fission or fusion, in response to the deletion of specific factors, results in a reduction in mitochondrial functionality. The fusion of mitochondria promotes repair and complementation processes, while damaged mitochondria are segregated from the network by fission, promoting mitophagy. Imbalanced mitochondrial dynamics and function are crucial underlying mechanisms for cellular toxicity, also leading to proteasome overload and reduced proteasome function. On the other hand, proteasome impairment results in mitochondrial dysfunction. Thus, there is a mutual interdependence between mitochondrial and proteasomal function. In this Special Issue, advances will be presented in our understanding of the relationship between mitochondria and proteasomes, particularly focusing on their role in diseases and describing possible therapeutic strategies.
Dr. Yanhua Yao
Guest Editors
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Keywords
- mitochondria function
- mitochondria dynamics
- proteasome
- ageing
- diseases
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