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Life
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The Endocrinology and Reproduction at High Altitude
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The Endocrinology and Reproduction at High Altitude

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".

Deadline for manuscript submissions: closed (14 July 2023) | Viewed by 941

Special Issue Editors

Prof. Dr. Gustavo F. Gonzales

E-Mail Website
Guest Editor
1. Laboratorio de Endocrinología y Reproducción, Laboratorios de Investigación y Desarrollo (LID), Departamento de Ciencias Biológicas y Fisiológicas, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima 15102, Peru
2. Instituto de Investigaciones de la Altura, Universidad Peruana Cayetano Heredia, Lima 15102, Peru
Interests: high altitude; endocrinology; human reproduction; adaptation; andrology; gynecology; pregnancy; metabolism; environmental health; medicinal plants
Dr. Arturo Eduardo Villena Pacheco

E-Mail Website
Guest Editor
1. Escuela de Tecnología Médica, Facultad de Medicina Alberto Hurtado, UPCH, San Martín de Porres, Peru
2. Insitituto de Investigaciones de la Altura, UPCH, San Martín de Porres, Peru
Interests: high altitude; endocrinology

Special Issue Information

Dear Colleagues,

It is estimated that there are around 500 million people born and living permanently at altitudes ≥1,500 m. Moreover, extensive populations from lowland areas are moving to high-altitude (HA) regions for work, tourism or sport. This subjects their bodies to acute, sub-acute, chronic, or intermittent exposure to hypoxia. People living in high-altitude environments have different adaptive mechanism that also depends on the duration of multigenerational residence.

Changes in human biology operate mainly above 3,000 meters above sea level. Important endocrine-metabolic changes have been described that constitute a pre-adaptive control response of intracellular systems to hypoxia that require systematization and analysis considering the notable advances in molecular biology.

High altitude presents a myriad of environmental stresses that provoke physiological responses and adaptation, and consequently impact in endocrine hormones and in reproduction. Endocrinology system is important for adaptation of living organism to different environments. High-altitude (HA) hypoxic environments represent one of the most serious challenges faced by humans that reside in these areas. Although hypoxia is the main component of the life at high altitudes, other environmental factors are also different to that observed at low altitudes as low temperatures, aridity, and high levels of UV radiation.

This Special Issue of Life, entitled "The Endocrinology and Reproduction at high altitude", invites papers dealing with all aspects of responses to life at high altitudes, including material on those that were born and live permanently in these regions, but also those that are exposed to HA for different periods of time after living at low altitudes.

Submissions on the physiological, molecular, cellular, and genetic aspects of endocrinology and reproduction at high altitudes are welcome, especially concerning populations living in the different high-altitude regions worldwide.

Prof. Dr. Gustavo F. Gonzales
Dr. Arturo Eduardo Villena Pacheco
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Peru
  • high altitude
  • endocrinology
  • environmental health
  • adaptation
  • anemia
  • health

Published Papers (1 paper)

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8 pages, 905 KiB  
Brief Report
Altitude Modifies the Effect of Parity on Birth Weight/Length Ratio: A Study Comprising 2,057,702 Newborns between 1984 and 2020 in Austria
by Eva Karner, Dana A. Muin, Katrin Klebermass-Schrehof, Thomas Waldhoer and Lin Yang
Life 2023, 13(8), 1718; https://doi.org/10.3390/life13081718 - 10 Aug 2023
Viewed by 708
Abstract
(1) Background: Lower birth weight among newborns in higher altitudes has been well documented in previous literature. Several possible causes for this phenomenon have been investigated, including biophysiological adaptation, epigenetic or genetic mechanisms or lifestyle changes. This is the first study to show [...] Read more.
(1) Background: Lower birth weight among newborns in higher altitudes has been well documented in previous literature. Several possible causes for this phenomenon have been investigated, including biophysiological adaptation, epigenetic or genetic mechanisms or lifestyle changes. This is the first study to show the effect modification of altitude and parity on the birth weight length ratio (BWLR) in women resident in moderate altitudes compared to a low sea level.; (2) Methods: This population-based study obtained data on altitude (0–300, 300–500, 500–700,700–900, >900 m), parity (1, 2, …, 7, 8/9), birth weight and length on all births in Austria between 1984 and 2020 from birth certificates provided by Statistics Austria. The BWLR was calculated, and the effect of moderate altitude and parity was estimated using multivariable linear mixed models adjusting for predefined variables. Sub-group regression analyses were conducted by altitude group. (3) Results: Data on 2,057,702 newborns from 1,280,272 mothers were analyzed. The effect of parity on BWLR, as indicated by the difference of BWLR between the first- and second-born infants, ranged between 1.87 to 2.09 g per centimeter across all altitude groups. Our analyses found that the effect of parity on BWLR diminished from parity three onwards at altitude 0–300, whilst the effect of parity on BWLR continued to increase at higher than 300 m and was most notable in the highest altitude group >900 m. (4) Conclusions: Findings from our study indicated that the negative effect of increasing altitude on BWLR was deprived for newborns of higher parity. It shows that the residential altitude can modify the effect of parity on BWLR. Full article
(This article belongs to the Special Issue The Endocrinology and Reproduction at High Altitude)
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