Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
2.7
3.2
Journals
Life
Special Issues
Advance in Microvascular Research
share announcement

Advance in Microvascular Research

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: closed (25 January 2024) | Viewed by 4472

Special Issue Editors

Dr. Panagiota Anyfanti

E-Mail Website
Guest Editor
Second Medical Department, Hippokration Hospital, Aristotle University of Thessaloniki, 54642 Thessaloniki, Greece
Interests: hypertension; vascular pathology; cardiovascular diseases; chronic inflammation; autoimmune rheumatic disorders
Special Issues, Collections and Topics in MDPI journals
Dr. Theodoros Dimitroulas

E-Mail Website
Guest Editor
Fourth Department of Internal Medicine, Hippokration University Hospital, Medical School, Aristotle University of Thessaloniki, 49 Konstantinoupoleos Street, 54642 Thessaloniki, Greece
Interests: autoimmune rheumatic disorders; rheumatoid arthritis; systemic sclerosis; microvascular injury; cardiovascular complications

Special Issue Information

Dear Colleagues,

Over the recent decades, our understanding of the microvasculature has greatly changed and is continuously expanding. The conventional concept of the microvasculature as an architectural component integral to all tissues has evolved to its perception as a dynamic cellular system with vital functions preserving tissue health and homeostasis. Rigorous, cutting-edge research in basic science and clinical medicine has focused on the evaluation of microvascular function and dysfunction in healthy conditions and diverse clinical settings. Microvascular dysfunction has emerged as a primary pathophysiological process that triggers and promotes the development of vascular complications in several systemic diseases, including hypertension, cardiovascular diseases and chronic inflammatory disorders. At the same, the list of systemic diseases characterized by microvascular dysfunction is continuously growing, from more or less common clinical syndromes to novel clinical entities, including the recent coronavirus disease 19 (COVID-19).

This Special Issue aims to provide a platform to disseminate novel advances in the field of microvascular research. The scope of this Special Issue covers a broad spectrum of microvascular research for basic science, clinicians and translational researchers. Research subjects of interest include microvascular structure, function and dysfunction; microvascular biology, physiology, and pathophysiology; mechanistic insights, and related therapeutic advances. Topics may include, but are not limited to, the study of the microvascular injury or dysfunction in the following areas:

  • Hypertension and cardiovascular diseases;
  • Chronic inflammatory and autoimmune rheumatic disorders;
  • Hematological and hemorheological disorders;
  • Novel entities characterized by microvascular injury, such as COVID-19.

Dr. Panagiota Anyfanti
Dr. Theodoros Dimitroulas
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microvascular injury
  • microvascular dysfunction
  • microcirculation
  • vascular inflammation
  • hypertension
  • cardiovascular diseases

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

12 pages, 2218 KiB  
Article
Angina and Non-Obstructive Coronary Artery (ANOCA) Patients with Coronary Vasomotor Disorders
by Sarena La, Rosanna Tavella, Jing Wu, Sivabaskari Pasupathy, Christopher Zeitz, Matthew Worthley, Ajay Sinhal, Margaret Arstall, John A. Spertus and John F. Beltrame
Life 2023, 13(11), 2190; https://doi.org/10.3390/life13112190 - 10 Nov 2023
Viewed by 1006
Abstract
Angina and Non-Obstructive Coronary Artery (ANOCA) patients often lack a clear explanation for their symptoms, and are frequently discharged with the label of “unspecified chest pain”, despite the availability of functional coronary angiography (provocative spasm and microvascular function testing) to identify potential underlying [...] Read more.
Angina and Non-Obstructive Coronary Artery (ANOCA) patients often lack a clear explanation for their symptoms, and are frequently discharged with the label of “unspecified chest pain”, despite the availability of functional coronary angiography (provocative spasm and microvascular function testing) to identify potential underlying coronary vasomotor disorders. This study compared the outcomes of ANOCA patients with a coronary vasomotor disorder diagnosis post elective coronary angiography to patients discharged with unspecified chest pain. Using the CADOSA (Coronary Angiogram Database of South Australia) registry, consecutive symptomatic patients (n = 7555) from 2012 to 2018 underwent elective angiography; 30% had ANOCA (stenosis <50%). Of this cohort, 9% had documented coronary vasomotor disorders diagnosed, and 91% had unspecified chest pain. Patients with coronary vasomotor disorders were younger and had a similar female prevalence compared with those with unspecified chest pain. New prescriptions of calcium channel blockers and long-acting nitrates were more common for the coronary vasomotor cohort at discharge. In the 3 years following angiography, both groups had similar all-cause mortality rates. However, those with coronary vasomotor disorders had higher rates of emergency department visits for chest pain (39% vs. 15%, p < 0.001) and readmissions for chest pain (30% vs. 10%, p < 0.001) compared with those with unspecified chest pain. This real-world study emphasizes the importance of identifying high-risk ANOCA patients for personalized management to effectively address their symptoms. Full article
(This article belongs to the Special Issue Advance in Microvascular Research)
►▼ Show Figures

Graphical abstract

13 pages, 1175 KiB  
Article
The Role of Systemic Oxidative Status in Coronary Arterial and Peripheral Venous Blood of Patients with Unstable Angina Pectoris
by Panic D. Dragan, Simic B. Ivan, Davidovic Z. Goran, Nikolic D. Maja, Lazarevic D. Nevena, Andjic M. Marijana, Vuckovic M. Jelena, Zornic J. Nenad, Zivkovic I. Vladimir, Tamara Nikolic Turnic, Jakovljevic Lj Vladimir and Iric Cupic M. Violeta
Life 2023, 13(7), 1537; https://doi.org/10.3390/life13071537 - 11 Jul 2023
Viewed by 1055
Abstract
(1) Background: We aimed to analyze the oxidative status of patients with unstable angina pectoris (UA), as well as to determine the correlation of these parameters between coronary arterial and peripheral venous blood samples. (2) Methods: The study included 47 human subjects with [...] Read more.
(1) Background: We aimed to analyze the oxidative status of patients with unstable angina pectoris (UA), as well as to determine the correlation of these parameters between coronary arterial and peripheral venous blood samples. (2) Methods: The study included 47 human subjects with UA and 45 control subjects. We performed clinical examinations, hemodynamic and coronary angiography measures. Also, in the blood samples, we measured routine laboratory markers and the concentration of pro-oxidants: index of lipid peroxidation (TBARS), superoxide anion radical (O2−), hydrogen peroxide (H2O2) and nitrites (NO2−), while antioxidant parameters were determined from red blood cells: reduced glutathione (GSH), catalase (CAT) and superoxide dismutase (SOD). All parameters were determined spectrophotometrically. (3) Results: Significantly higher values of TBARS and all measured antioxidants SOD, CAT and GSH were observed in the coronary arterial blood of the UA group relative to coronary arterial blood of the control subjects. On the other hand, in the peripheral venous blood samples, a significantly lower GSH value was found in the UA group compared to the control. (4) Conclusions: This study has shown that the majority of changes in all measured redox markers are found in coronary blood, especially related to the activity of antioxidant components. In patients with an unstable form of angina, prooxidants (superoxide anion radical and index of lipid peroxidation) and endogenous antioxidants (catalase, superoxide dismutase and reduced glutathione) are in direct correlation with the course of ischemic disease. Future studies, where participants would be randomized depending on symptom duration, are necessary to confirm these conclusions. Full article
(This article belongs to the Special Issue Advance in Microvascular Research)
►▼ Show Figures

Figure 1

13 pages, 2094 KiB  
Article
Blunted Microvascular Reactivity in Psoriasis Patients in the Absence of Cardiovascular Disease, as Assessed by Laser Speckle Contrast Imaging
by Anastasia Margouta, Panagiota Anyfanti, Antonios Lazaridis, Barbara Nikolaidou, Konstantinos Mastrogiannis, Anastasia Malliora, Aikaterini Patsatsi, Areti Triantafyllou, Stella Douma, Michael Doumas and Eugenia Gkaliagkousi
Life 2022, 12(11), 1796; https://doi.org/10.3390/life12111796 - 6 Nov 2022
Cited by 8 | Viewed by 1597
Abstract
Psoriasis is associated with accelerated rates of cardiovascular disease (CVD). Laser Speckle Contrast Imaging (LSCI) is a novel, non-interventional technique for the dynamic assessment of microvascular endothelial dysfunction, which represents an early precursor of CVD. We investigated whether skin microvascular reactivity is impaired [...] Read more.
Psoriasis is associated with accelerated rates of cardiovascular disease (CVD). Laser Speckle Contrast Imaging (LSCI) is a novel, non-interventional technique for the dynamic assessment of microvascular endothelial dysfunction, which represents an early precursor of CVD. We investigated whether skin microvascular reactivity is impaired in psoriasis and whether an association exists with large artery stiffening. Skin microvascular reactivity was assessed with LSCI combined with post-occlusive reactive hyperaemia protocol in psoriasis patients and controls in the absence of established CVD. Arterial stiffness and central hemodynamics were assessed throughout a whole 24 h period with the Mobil-O-Graph device. Most LSCI indices of microvascular reactivity were impaired in psoriasis patients (n = 90) compared to controls (n = 45) [baseline flux; occlusion flux; peak-to-baseline magnitude; baseline cutaneous vascular conductance (CVC); percentage increase in CVC, p < 0.001 for all comparisons]. In multivariate analysis, psoriatic disease predicted the above markers independently of classical CVD risk factors. Augmentation index, peripheral pulse pressure, and central systolic/diastolic blood pressure correlated with LSCI microvascular responses in the study population (n = 135). Pulse wave velocity significantly correlated with nearly all LSCI parameters, while the association with baseline flux was independent of CVD risk factors and psoriatic disease in multivariate analysis (beta = 0.096, p = 0.039). This study provides evidence of altered skin microvascular responses in psoriasis by use of LSCI, and interaction with macrovascular dysfunction, before the establishment of overt CVD. A non-interventional approach of skin microcirculation with LSCI might be used as an early indicator of vascular health in psoriasis. Full article
(This article belongs to the Special Issue Advance in Microvascular Research)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop