Dermatology: Understanding of the Pathophysiology and Therapeutic Implications
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".
Deadline for manuscript submissions: closed (20 October 2023) | Viewed by 6975
Special Issue Editors
Interests: immune and allergic skin disorders; infectious diseases; tumors biologic therapy; pathophysiology
Interests: cellular immunity; cytokines; monoclonal antibodies; microbiota; biologic therapy; immune disorders
Special Issue Information
Dear Colleagues,
Dermatology has seen significant progress lately regarding the knowledge of the main pathophysiological mechanisms of some chronic diseases, of high-performance imaging explorations such as dermoscopy, confocal microscopy or optical coherence tomography, especially for skin tumors, but also a more precise therapeutic approach of certain disorders (psoriasis, atopic dermatitis, vitiligo, hidradenitis suppurativa, chronic urticaria, etc.).
Thus, understanding pathogenic mechanisms of some frequent immune diseases has brought to attention the involvement of innate and acquired immunity and their products, chemokines and pro- and anti-inflammatory cytokines. These have enabled new therapeutic approaches with emphasis on biological therapy. However, there are still many unknown facts regarding the main pathophysiological process of these conditions which causes limitation of the treatment approach, especially in psoriasis and atopic dermatitis. Although psoriasis is a disease in which cellular immunity predominates, scientific research has shown that therapy with monoclonal antibodies or fusion proteins can lead to clearance of lesions. Although in psoriasis there are lymphocytes responsible for stimulating keratinocytes, no one has yet asked the question, why don't we use a cell biological therapy and not a humoral one? Why don't we destroy the lymphocytes responsible for the pathophysiology of psoriasis, but just reduce the effectors (cytokines and chemokines) of these cells. One explanation would be the current scientific limitation, which does not yet allow the distribution of large cellular structures (lymphocytes) to the blood or skin (although these lymphocytes have specific surface markers by which they can be identified, as can pathogenic cells). Scientific research has made major progress, but we still fail to destroy the pro-inflammatory cytokine and chemokine producing cells in psoriasis.
On the other hand, advances in dermatology aim to introduce more sensitive "in vivo '' diagnostic methods in order to provide results as similar as possible to "in vitro" methods.
In this context, the Special Issue entitled "Dermatology: Understanding of the Pathophysiology and Therapeutic Implications'' focuses on publishing high scientific value papers targeting both common and rare diseases, with or without genetic predisposition, but difficult to diagnose. Also, modern non-invasive methods of diagnosis and treatment will play an important part. These can be presented as original articles, review articles etc., authors' experience adding value to clinical and basic research in dermatology.
We look forward to receiving your articles.
Prof. Dr. Simona Laura Ianoși
Prof. Dr. Remus Orasan
Guest Editors
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Keywords
- cellular immunity
- cytokines
- immune cells
- monoclonal antibodies
- psoriasis
- atopic dermatitis
- acne
- chronic venous insufficiency
- skin immune disorders
- biological treatment
- infectious diseases
- allergic skin disease
- skin tumors
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