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Life
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New Diagnostic and Therapeutic Developments in Eye and Systemic Diseases
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New Diagnostic and Therapeutic Developments in Eye and Systemic Diseases

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 6432

Special Issue Editor

Dr. Zhihong (Jewel) Hu

E-Mail Website
Guest Editor
Doheny Image Analysis Laboratory, Doheny Eye Institute, Pasadena, CA 91103, USA
Interests: artificial intelligence (AI); machine learning, deep learning, and computer vision in the fields of automated screening and classification; novel biomarker discovery; quantitative prediction of progressive growth; image segmentation and registration of 2D and 3D images with various eye diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Ophthalmology has been at the forefront of medical innovation due to its unique demand for device-assisted diagnostics and microsurgery. Recent technological developments have radically impacted the daily practices of ophthalmologists thanks to the advent of novel diagnostic and therapeutic tools that facilitate the early diagnosis of eye diseases and systemic diseases (i.e., oculomics), allowing for the better management of not only ocular disorders but also systemic disorders affecting the entire body. The use of modern devices not only permits the earlier detection of eye diseases and systemic diseases but also allows ophthalmologists to offer more individualized treatment to their patients. For this Special Issue, we request research including new findings in the fields of diagnostic and therapeutic developments in eye diseases and systemic diseases. Our goal is to discuss, amongst others, diagnostic imaging, molecular pathology diagnosis (biomarkers), artificial intelligence diagnosis, and innovative treatment options in the field of ophthalmology.

Primarily, we welcome submissions of high-quality original research articles showcasing new developments and innovative findings on these topics. Secondarily, we will consider high-interest review articles and case series of exceptional quality.

Dr. Zhihong Jewel Hu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • eye diseases
  • systemic diseases
  • oculomics
  • ocular imaging
  • eye surgery
  • retina
  • cornea
  • glaucoma
  • refractive surgery
  • OCT
  • OCTA

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (4 papers)

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Research

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18 pages, 7301 KiB  
Article
Mydriasis Stability During Cataract Surgery in Patients with Systemic Comorbidities Using a Standardised Combination of Intracameral Mydriatics and Anaesthetic
by Joanna Dereń-Szumełda, Mariola Dorecka, Mirosław Dereń and Ewa Mrukwa-Kominek
Life 2025, 15(1), 119; https://doi.org/10.3390/life15010119 - 17 Jan 2025
Viewed by 826
Abstract
Background: This study aimed to evaluate mydriasis stability during cataract surgery in patients with systemic comorbidities such as diabetes mellitus (DM) and pseudoexfoliation syndrome (PXF) after a standardised combination of intracameral mydriatics and anaesthetic (SCIMA). Stable mydriasis is crucial for safe and effective [...] Read more.
Background: This study aimed to evaluate mydriasis stability during cataract surgery in patients with systemic comorbidities such as diabetes mellitus (DM) and pseudoexfoliation syndrome (PXF) after a standardised combination of intracameral mydriatics and anaesthetic (SCIMA). Stable mydriasis is crucial for safe and effective phacoemulsification. Methods: Patients were included if they achieved pupil dilation ≥6.0 mm during the qualifying visit. A total of 103 patients were enrolled, divided into three groups: cataract with diabetes (C + DM group, n = 35), cataract with PXF (C + PXF group, n = 32), and cataract without those comorbidities (C group, n = 36). SCIMA was administered, and pupil diameters were measured at key surgical stages. Stability was defined as a pupil diameter of ≥6.0 mm without additional pharmacological intervention and no significant change in its diameter (≥3.0 mm). Results: Stable mydriasis was achieved in 90.3% of patients: 97.1% in the C + DM group, 90.6% in the C + PXF group, and 83.3% in the C group, with no statistically significant differences (p = 0.14). Conclusions: SCIMA effectively maintains mydriasis stability during cataract surgery, even in patients with systemic comorbidities, ensuring greater surgical safety. Full article
(This article belongs to the Special Issue New Diagnostic and Therapeutic Developments in Eye and Systemic Diseases)
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9 pages, 536 KiB  
Article
Visual Performance After Bilateral Implantation of a New Enhanced Monofocal Hydrophobic Acrylic Intraocular Lens Targeted for Mini-Monovision
by Hugo A. Scarfone, Emilia C. Rodríguez, Jerónimo Riera, Maira Rufiner and Martín Charles
Life 2025, 15(1), 64; https://doi.org/10.3390/life15010064 - 7 Jan 2025
Viewed by 972
Abstract
Background: The aim of this study was to evaluate visual outcomes and patient satisfaction after bilateral implantation of a new hydrophobic acrylic intraocular lens called Clareon (Alcon) using the mini-monovision technique. Methods: A single-center, prospective, nonrandomized study was conducted in Tandil (Buenos Aires, [...] Read more.
Background: The aim of this study was to evaluate visual outcomes and patient satisfaction after bilateral implantation of a new hydrophobic acrylic intraocular lens called Clareon (Alcon) using the mini-monovision technique. Methods: A single-center, prospective, nonrandomized study was conducted in Tandil (Buenos Aires, Argentina), including patients scheduled for cataract surgery. To achieve mini-monovision, the spherical equivalent was calculated between −0.25 and +0.25 D for the dominant eye, and between −0.75 and −1.00 D for the non-dominant eye. The main outcomes were uncorrected distance visual acuity (UDVA) and uncorrected intermediate visual acuity (UIVA) evaluated at 66 cm. A secondary outcome, patient satisfaction, was assessed using the CatQuest-9SF questionnaire. Results: The mean binocular UDVA was 0.01 ± 0.05 logMAR three months after surgery, while the mean binocular UIVA was 0.20 ± 0.06 logMAR. The postoperative mean spherical equivalent in the dominant eye was −0.27 ± 0.12, and in the non-dominant eye was −0.87 ± 0.25. Before surgery, the CatQuest-9SF questionnaire revealed that 83.33% of patients were dissatisfied with their vision during daily activities. Over 50% reported significant difficulties with reading newspapers, sewing, and reading TV subtitles. Additionally, 66.6% struggled with recognizing faces, 50% with seeing product prices, and 50% with walking on uneven ground. Post-surgery, most patients experienced improved vision for daily tasks, with no reports of high dissatisfaction or significant difficulties. Patients were quite satisfied with their vision for hobbies and TV subtitles, and very satisfied (90%) with seeing supermarket prices. Conclusions: patients implanted with a new enhanced monofocal IOL using the mini-monovision technique showed improved distance and intermediate visual acuity, reduced need for glasses, and expressed a high degree of satisfaction. Full article
(This article belongs to the Special Issue New Diagnostic and Therapeutic Developments in Eye and Systemic Diseases)
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11 pages, 2104 KiB  
Article
Short-Term Visual and Refractive Outcomes of Single-Step Transepithelial Photorefractive Keratectomy with Amaris 750S and SmartSurfACE in Myopia and Astigmatism: A 6-Month Follow-Up Study
by Daiana-Andreea Margarit, Horia Tudor Stanca, Valeria Mocanu, Mihnea Munteanu, Suta Marius and Suta Gheorghita
Life 2024, 14(10), 1288; https://doi.org/10.3390/life14101288 - 11 Oct 2024
Viewed by 1348
Abstract
Background: Single-step transepithelial photorefractive keratectomy (TPRK) is a modern refractive surgery technique that offers a no-touch approach for correcting myopia and astigmatism. This study aims to evaluate the short-term visual and refractive outcomes of TPRK in patients with myopia and astigmatism over a [...] Read more.
Background: Single-step transepithelial photorefractive keratectomy (TPRK) is a modern refractive surgery technique that offers a no-touch approach for correcting myopia and astigmatism. This study aims to evaluate the short-term visual and refractive outcomes of TPRK in patients with myopia and astigmatism over a 6-month follow-up period. Methods: This retrospective cohort study included patients who underwent single-step TPRK using the Amaris 750S laser platform with SmartSurfACE and SmartPulse® technologies, targeting a plano refraction. Procedures were performed with aspheric, non-wavefront-guided profiles, and outcomes were assessed postoperatively. Results: 96% of eyes achieved 20/20 or better uncorrected distance visual acuity (UDVA), with 98% reaching 20/25 or better, and 100% achieving 20/32 or better. UDVA was the same or better than preoperative corrected distance visual acuity (CDVA) in 96% of eyes, and no eyes lost two or more Snellen lines. Refractive outcomes showed strong precision, with 93% of eyes within ±1.00 D of the target. Astigmatism correction was accurate, with 100% of eyes having ≤1.00 D of astigmatism, and 80% achieving a precise astigmatism angle of error between −5° and 5°. Conclusion: Single-step TPRK with SmartSurfACE and SmartPulse® technologies provides highly effective and predictable visual and refractive outcomes for myopia and astigmatism. The procedure consistently delivers precise corrections with minimal complications, making it a reliable option for refractive surgery. Full article
(This article belongs to the Special Issue New Diagnostic and Therapeutic Developments in Eye and Systemic Diseases)
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Review

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15 pages, 1737 KiB  
Review
Therapeutic Effects of Taurine and Histidine Supplementation in Retinal Diseases
by Deokho Lee and Lois E. H. Smith
Life 2024, 14(12), 1566; https://doi.org/10.3390/life14121566 - 29 Nov 2024
Viewed by 2629
Abstract
Amino acids are basic building blocks of structural proteins and enzymes. They also act as signaling molecules and as fuel. They are characterized as essential if sufficient quantities must be supplied exogenously or as non-essential if they can be endogenously synthesized. Appropriate intake [...] Read more.
Amino acids are basic building blocks of structural proteins and enzymes. They also act as signaling molecules and as fuel. They are characterized as essential if sufficient quantities must be supplied exogenously or as non-essential if they can be endogenously synthesized. Appropriate intake of amino acids not only prevents the development of metabolic diseases but also can reduce the progression of some disease states. Amino acids are strongly associated with retinal metabolism in physiology and pathology. Nonetheless, there is a lack of robust clinical studies supporting the benefits of amino acid supplementation in retinopathy. In this review, we summarize preclinical evidence concerning the potential of supplementing the amino acids taurine and histidine to provide protection against diabetic retinopathy, glaucoma, and age-related macular degeneration. We suggest further directions for studying amino acid-based therapeutic interventions for eye diseases. Full article
(This article belongs to the Special Issue New Diagnostic and Therapeutic Developments in Eye and Systemic Diseases)
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