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Life
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Understanding Interstitial Cells
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Understanding Interstitial Cells

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Cell Biology and Tissue Engineering".

Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 2300

Special Issue Editors

Dr. Ping Yang

E-Mail Website
Guest Editor
MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China
Interests: interstitial cells; connective tissue; telocyte; fibroblast
Special Issues, Collections and Topics in MDPI journals
Dr. Tengfei Liu

E-Mail Website
Guest Editor
College of Veterinary Medicine, Northwest A&F University, Yangling 712100, China
Interests: Leydig cells; connective tissue; apoptosis; cell deaths

Special Issue Information

Dear Colleagues,

A vague term encompassing fibroblasts, macrophages, Leydig cells, telocytes, dendritic cells, pericytes, interstitial cells of Cajal, etc. is identified as an interstitial cell which shares connective tissue components with parenchymal cells and fills the space outside functional cells. Interstitial cells can be easily seen in many locations on animal bodies, such as the dermis of the skin, mucosal layer of the intestine, medulla and cortex of the kidney, seminiferous tubules of the testes, etc. Although their biological importance is unquestionable, the level of their intra- and inter-organ properties deserves attention since it has rarely been analyzed in detail. In this issue, we hope to focus on the spatial structure, plasticity change and molecular biological levels, grouping and real influence of interstitial cells in in vivo and in vitro studies, including healthy and diseased tissues and organs.

Novel insights into morphological structure, classification, function, and physiology of interstitial cells and connected tissues are invited. Immunologic and regenerative effects on tissue and organ function involved in interstitial cells will be of special interest. Integrative analyses of gene and protein, regulatory mechanisms through different omics research on the origin, and differentiation of interstitial cells, including the use of newly described and advanced ideas, are especially invited. Outstanding experts interested in this thematic issue are very welcome to send original manuscripts and reviews dealing with any of the cells mentioned above.

Dr. Ping Yang
Dr. Tengfei Liu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • interstitial cell
  • fibroblasts
  • macrophages
  • Leydig cells
  • Telocyte
  • dendritic cells
  • pericyte
  • interstitial cells of Cajal

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Published Papers (1 paper)

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Research

20 pages, 6326 KiB  
Article
RNA-Sequencing Analysis of Gene-Expression Profiles in the Dorsal Gland of Alligator sinensis at Different Time Points of Embryonic and Neonatal Development
by Haitao Nie, Yuqian Zhang, Shulong Duan, Ying Zhang, Yunlu Xu, Jixiang Zhan, Yue Wen and Xiaobing Wu
Life 2022, 12(11), 1787; https://doi.org/10.3390/life12111787 - 4 Nov 2022
Cited by 3 | Viewed by 1859
Abstract
Significant advances have been made in the morphological observations of the dorsal gland (DG), an oval organ/tissue which lies on both sides of the dorsal midline of the crocodilian. In the current study, RNA sequencing (RNA-seq) was used to identify the changing patterns [...] Read more.
Significant advances have been made in the morphological observations of the dorsal gland (DG), an oval organ/tissue which lies on both sides of the dorsal midline of the crocodilian. In the current study, RNA sequencing (RNA-seq) was used to identify the changing patterns of Alligator sinesis DGs at different timepoints from the 31st embryonic day (E31) to the newly hatched 1st day (NH1). A comprehensive transcriptional changes of differentially expression gene (DEGs) involved in the melanogenesis, cholesterol metabolism, and cell apoptosis pathways suggested that the DG might serves as a functional secretory gland in formation, transport and deposition of pigment, and lipids secretion via lysosomal exocytosis. Furthermore, the remarkable immunohistochemical staining of proliferating cell nuclear antigen (PCNA) and B-cell lymphoma 2 (Bcl-2)-positive signals in the basilar cells, in parallel with the immuno-reactive TdT-mediated dUTP nick-End labeling(TUNEL) within suprabasal cells, provided direct molecular evidence supporting for the speculation that DG serves as a holocrine secretion mode. Finally, subsequent phylogenetic and immunohistochemical analysis for the PITX2, the identified DEGs in the RNA-seq, was helpful to further elucidate the transcriptional regulatory mechanism of candidate genes. In conclusion, the current results are of considerable importance in enriching our understanding of the intrinsic relationship between the skin derivatives and lifestyles of newborn Alligator sinesis. Full article
(This article belongs to the Special Issue Understanding Interstitial Cells)
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