Innovations in Pathology and Viral Oncology

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".

Deadline for manuscript submissions: closed (17 February 2025) | Viewed by 1211

Special Issue Editor


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Guest Editor
Department of Life Sciences, Health, and Healthcare Professions, Link Campus University, Rome, Italy
Interests: pathology; oncology; gynecology; senology; human papilloma virus (HPV); HPV-test; PAP-test; Epstein–Barr virus (EBV); human herpes virus 8 (HHV8); coronavirus disease 2019 (COVID-19); severe acute respiratory syndrome (SARS); middle east respiratory syndrome (MERS); Nipah virus; Ebola virus

Special Issue Information

Dear Colleagues,

Viral oncology deals with the study, diagnosis and treatment of tumors induced by viral infections. The so called oncoviruses are equipped with either a DNA or RNA genome. The well-known DNA oncovirus associated with tumors in women and men is the human papilloma virus (HPV), responsible for cancers of the cervix, vagina, vulva, anus, penis and oropharynx. Other well-known oncoviruses include the following: I) Epstein–Barr virus (EBV), or human herpesvirus 4 (HHV4), associated with Burkitt’s lymphoma, Hodgkin’s lymphoma, post-transplant lymphoproliferative disease (PTLD), nasal-type lymphoma, nasopharyngeal carcinoma; II) Kaposi’s sarcoma-associated herpesvirus, or human herpesvirus 8 (HHV-8), responsible for Kaposi’s sarcoma, multicentric Castleman’s disease, primary effusion lymphoma; III) hepatitis B and C viruses, causing hepatocarcinoma; IV) human T-lymphotropic virus (HTLV), associated with adult T-cell leukemia; and V) Merkel cell polyomavirus (MCV), recently discovered to be the etiological agent of Merkel cell carcinoma. Nowadays, bioptic analyses remain the gold standard for the diagnosis of these tumors , and the detection of the underlying oncovirus is achieved by exploiting ancillary techniques of immunohistochemistry (IHC) or molecular in situ hybridization (ISH). Therefore, the scope of this Special Issue is any innovative approach in the diagnosis, therapy, screening and prevention of virus-induced cancers; moreover, clinicopathological correlations are welcome.

Prof. Dr. Luca Roncati
Guest Editor

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Keywords

  • pathology
  • viral oncology
  • gynecological oncology
  • hematological oncology
  • head and neck tumors
  • human papilloma virus (HPV)
  • HPV-test
  • PAP-test
  • oncoviruses
  • cancer

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Published Papers (1 paper)

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Review

27 pages, 1120 KiB  
Review
Enhancing Cervical Cancer Screening: New Diagnostic Methodologies, Triage, and Risk Stratification in Prevention and Treatment
by Nazira Kamzayeva, Gauri Bapayeva, Milan Terzic, Berik Primbetov, Balkenzhe Imankulova, Yevgeniy Kim, Arailym Sultanova, Kuralay Kongrtay, Nazira Kadroldinova and Talshyn Ukybassova
Life 2025, 15(3), 367; https://doi.org/10.3390/life15030367 - 26 Feb 2025
Viewed by 930
Abstract
Human papillomavirus (HPV) is a well-established etiological factor in the development of precancerous cervical lesions and cervical cancer. This narrative review synthesizes current evidence on the global prevalence, genotype distribution, and pathophysiological mechanisms of HPV infection, emphasizing regional epidemiological variations that influence prevention [...] Read more.
Human papillomavirus (HPV) is a well-established etiological factor in the development of precancerous cervical lesions and cervical cancer. This narrative review synthesizes current evidence on the global prevalence, genotype distribution, and pathophysiological mechanisms of HPV infection, emphasizing regional epidemiological variations that influence prevention and treatment strategies. Particular attention is given to high-risk HPV genotypes, their role in carcinogenesis, and the impact of co-infections and the cervicovaginal microbiota on infection persistence and disease progression. Advances in diagnostic methodologies, including E6/E7 oncoprotein detection, DNA methylation, and microRNA-based assays, are examined in the context of improving screening accuracy and early detection. Furthermore, the review explores the psychological implications of HPV diagnosis and underscores the importance of integrating psychosocial support into clinical management. Given the challenges associated with screening coverage, the potential of self-sampling techniques, particularly in resource-limited settings, is discussed as a means to enhance accessibility and participation in cervical cancer prevention programs. By providing a comprehensive overview of these interrelated factors, this review highlights the necessity of a multidisciplinary approach that integrates novel diagnostic strategies, targeted prevention efforts, and supportive care to mitigate the burden of HPV-associated diseases. Full article
(This article belongs to the Special Issue Innovations in Pathology and Viral Oncology)
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