Advancements in Veterinary Oncology

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Animal Science".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 1949

Special Issue Editors


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Guest Editor
1. CECAV-Veterinary and Animal Research Center, University of Trás-os-Montes e Alto Douro, 5000-801 Vila Real, Portugal
2. Associate Laboratory for Animal and Veterinary Sciences (AL4AnimalS), 5000-801 Vila Real, Portugal
3. CIVG–Vasco da Gama Research Center, EUVG–Vasco da Gama University School, 3020-210 Coimbra, Portugal
Interests: veterinary oncology; immunohistochemistry; equine medicine

E-Mail
Guest Editor
1. CECAV-Veterinary and Animal Research Center, University of Trás-os-Montes e Alto Douro, 5000-801 Vila Real, Portugal
2. Associate Laboratory for Animal and Veterinary Sciences (AL4AnimalS), 5000-801 Vila Real, Portugal
3. Faculty of Veterinary Medicine, Lusófona University, Campo Grande 376, 1749-024 Lisbon, Portugal
Interests: veterinary oncology; equine medicine

E-Mail
Guest Editor
1. CECAV-Veterinary and Animal Research Center, University of Trás-os-Montes e Alto Douro, 5000-801 Vila Real, Portugal
2. Associate Laboratory for Animal and Veterinary Sciences (AL4AnimalS), 5000-801 Vila Real, Portugal
3. Veterinary Sciences Department, University of Trás-os-Montes e Alto Douro, 5000-801 Vila Real, Portugal
Interests: skin tumors; neuropathology; dermatology and dermatopathology; veterinary forensics
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
1. CECAV-Veterinary and Animal Research Center, University of Trás-os-Montes e Alto Douro, 5000-801 Vila Real, Portugal
2. Associate Laboratory for Animal and Veterinary Sciences (AL4AnimalS), 5000-801 Vila Real, Portugal
3. Veterinary Sciences Department, University of Trás-os-Montes e Alto Douro, 5000-801 Vila Real, Portugal
Interests: pathology; veterinary forensics; oncology; wildlife conservation; animal cancer registry; immunology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Veterinary Oncology has rapidly evolved, bringing transformative advancements that significantly enhance the knowledge about carcinogenesis, diagnosis, treatment, and prognosis of cancer in animals. This Special Issue, titled "Advancements in Veterinary Oncology", is dedicated to presenting the latest research in this the field, offering new perspectives for both companion animals and horses.

Cancer is a leading cause of morbidity and mortality in veterinary patients, necessitating a multifaceted approach to address its complexities. This Special Issue covers a broad spectrum of topics in veterinary oncology, from basic research to diagnostics, treatment modalities, and prognostic evaluations. Our goal is to provide a comprehensive overview of the current state of veterinary cancer research and the strides being made to improve outcomes for our veterinary patients. In this Special Issue, original articles, case reports, and reviews are welcome.

This Special Issue also emphasizes the importance of comparative oncology, illustrating how advancements in human cancer research can be translated to veterinary practice and vice versa. By leveraging this comparative approach, we can accelerate the development of effective treatments and deepen our understanding of cancer biology across species.

As the Guest Editors of this Special Issue, we extend our heartfelt gratitude to the authors for their exceptional contributions and to the reviewers for their meticulous evaluation of the submissions. We are confident that the research presented herein will inspire further innovation and collaboration, driving forward the field of veterinary oncology.

We invite all the researchers to explore the articles in this Special Issue and join us in recognizing the remarkable progress being made in oncology in veterinary medicine. Together, we can continue to advance our understanding of cancer, bringing new hope and better health outcomes to animals.

Dr. José Pimenta
Dr. Mário Pedro Goncalves Cotovio
Dr. Justina Prada
Dr. Isabel Pires
Guest Editors

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • veterinary and comparative oncology
  • epidemiology
  • tumor biology
  • diagnosis
  • treatment
  • biomarkers

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Published Papers (1 paper)

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Research

15 pages, 838 KiB  
Article
The Impact of a Western Diet and Resistance Training in a Rat Model of Mammary Cancer
by Jessica Silva, Tiago Azevedo, Rita Ferreira, Maria J. Neuparth, Fernanda Seixas, Mário Ginja, Maria J. Pires, Ana I. Faustino-Rocha, José Alberto Duarte and Paula A. Oliveira
Life 2025, 15(2), 250; https://doi.org/10.3390/life15020250 - 6 Feb 2025
Viewed by 715
Abstract
This study aimed to investigate the impact of a Western diet and resistance training on cardiac remodeling in a rat model of chemically induced mammary cancer. Fifty-six female Wistar rats were randomly assigned to one of eight experimental groups, evaluating the impact of [...] Read more.
This study aimed to investigate the impact of a Western diet and resistance training on cardiac remodeling in a rat model of chemically induced mammary cancer. Fifty-six female Wistar rats were randomly assigned to one of eight experimental groups, evaluating the impact of Western and standard diets, exercise and sedentarism, and the induction of mammary cancer. Mammary cancer was induced via the intraperitoneal administration of N-methyl-N-nitrosourea (MNU) (50 mg/kg) at seven weeks of age. The resistance training protocol consisted of ladder climbing three times per week for an 18-week period, with a gradual increase in load over time. At the end of the 20-week experimental period, the animals were anesthetized and underwent echocardiography. Subsequently, the animals were euthanized, and organs and visceral adipose tissue (VAT) were collected and analyzed. A histopathological examination was performed on the mammary tumors. The Western diet increased relative VAT and contributed to cardiovascular and tumor-related changes, including an increase in interventricular septum thickness (IVS) and left ventricle posterior wall thickness (LVPW) at end-systole. Exercise reduced fat accumulation, improved cardiac performance, and helped regulate cardiovascular function, as indicated by a higher eccentricity index (EI) in the WD+EX group compared to the WD group. The WD was associated with increased VAT accumulation and initially delayed tumor initiation; however, over time, it contributed to bigger tumor aggressiveness. This diet also delayed tumor initiation but increased LVPW. Exercise, when combined with a WD, accelerated tumorigenesis, malignant transformation and invasiveness, resulted in the higher prevalence of invasive tumors. These findings underscore the complex and potentially compounding effects of diet and exercise on cancer progression. Full article
(This article belongs to the Special Issue Advancements in Veterinary Oncology)
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