Molecular Pathomechanisms and Biomarkers of Alzheimer's Disease

Dear Colleagues,

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the leading cause of dementia in elderly people. With approximately 50 million cases worldwide, AD represents a major medical and socio-economic burden. The most common form of the disease is sporadic late-onset AD, which accounts for approximately 90% of all cases and typically develops after the age of 65. AD is a multifactorial disease that results from a complex interplay between environmental, lifestyle, genetic, and epigenetic factors. Despite significant advancements in recent decades, the exact cause of the disease and processes leading to the development of amyloid and tau pathology, neuroinflammation, neurodegeneration, and other AD-related abnormalities are still not fully understood. Efforts to uncover the key cellular and molecular players in the pathological process promise the establishment of new screening, diagnostic, predictive, and monitoring biomarkers for AD as well as the development of novel effective therapeutic strategies.

In this Special Issue, we aim to publish review and original research articles that could fuel the efforts to better understand the processes underlying AD development. We would like to invite submissions addressing a broad range of topics including, but not limited to, the following: genetic and epigenetic risk factors of AD, the role of innate and adaptive immune mechanisms, oxidative stress, hormones and metabolic alterations in AD development and progression, the link between the gut microbiome and AD, and new neuroimaging and biofluid-based biomarkers for AD diagnostics.

Dr. Juraj Javor
Dr. Ivana Shawkatová
Guest Editors

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