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Life
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New Insights into Pediatric Cardiology
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New Insights into Pediatric Cardiology

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 6866

Special Issue Editors

Dr. Corina Maria Vasile

E-Mail Website
Guest Editor
Department of Pediatric and Adult Congenital Cardiology, University Hospital of Bordeaux, 33600 Bordeaux, France
Interests: echocardiography; pediatric cardiology; congenital heart disease; congenital cardiopathy in adults; artificial intelligence; automatic measurements
Special Issues, Collections and Topics in MDPI journals
Dr. Eliza Cinteză

E-Mail Website
Guest Editor
Department of Pediatrics, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania
Interests: pediatric cardiology; echocardiography; arterial hypertension; interventional cardiology; arrhythmias; congenital heart disease; genetic testing; clinical practice
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, diagnostic modalities and therapeutic options in pediatric cardiology have shown revolutionary developments, resulting in the development of newer medical, interventional, and surgical techniques with increasing survival rates. A continuous improvement in the quality of life of these patients has been achieved. Modern treatment of congenital heart malformations has led to normal or near-normal adult life, even in many complicated malformations that were previously fatal.

Pediatric cardiology problems will persist but change their course due to prenatal interventions and early postnatal treatment.

Early interventions have created a new population of adult heart patients. Even though most patients have excellent postoperative outcomes, they can develop new secondary cardiovascular problems. These will require regular medical follow-up and possibly more secondary cardiovascular interventions.

Over the years, genetics, embryology, and morphology have increased our knowledge of cardiovascular development and the inheritance of certain diseases.

The pediatric cardiac population that will reach adulthood is progressively increasing; thus, the medical community faces new challenges—some of these will involve pediatric cardiologists, but predominantly adult cardiologists and cardiovascular surgeons.

The pediatric cardiology patient population is smaller than that of adult cardiology but has equal needs. Human and material resources are mandatory to achieve and maintain a continuously high standard of care.

This Special Issue aims to provide a rich mix of original papers, reviews, and case reports on many aspects of understanding, managing, and preventing cardiovascular disease in childhood. Primary care in pediatric cardiology must be concerned with preventing heart disease and detecting existing conditions early. In addition, pediatricians must maintain the vigilance of 'healthy' children to control cardiovascular risk in adulthood. With these goals in mind, the potential topics include, but are not limited to:

  • pediatric cardiology;
  • congenital heart disease;
  • echocardiography;
  • congestive heart failure;
  • ventricular septal defect;
  • pulmonary stenosis;
  • coarctation of the aorta;
  • atrial septal defect;
  • pulmonary hypertension;
  • arterial hypertension;
  • syncope;
  • arrhythmias;
  • cardiac transplantation;
  • cardiomyopathy;
  • pediatric interventional cardiology;
  • children;
  • newborn;
  • cardiac surgery, and family practice for congenital heart disease.

Dr. Corina Maria Maria Vasile
Dr. Eliza Elena Cintezǎ
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pediatric cardiology
  • patentus ductus arteriosus
  • interventional cardiology
  • cardiac catheterization
  • echocardiography
  • congenital heart disease
  • cardiac enzymes

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Published Papers (3 papers)

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Review

18 pages, 1749 KiB  
Review
Exploring New Drug Repurposing Opportunities for MEK Inhibitors in RASopathies: A Comprehensive Review of Safety, Efficacy, and Future Perspectives of Trametinib and Selumetinib
by Andrea Gazzin, Federico Fornari, Simona Cardaropoli, Diana Carli, Marco Tartaglia, Giovanni Battista Ferrero and Alessandro Mussa
Life 2024, 14(6), 731; https://doi.org/10.3390/life14060731 - 6 Jun 2024
Cited by 2 | Viewed by 2218
Abstract
The RASopathies are a group of syndromes caused by genetic variants that affect the RAS-MAPK signaling pathway, which is essential for cell response to diverse stimuli. These variants functionally converge towards the overactivation of the pathway, leading to various constitutional and mosaic conditions. [...] Read more.
The RASopathies are a group of syndromes caused by genetic variants that affect the RAS-MAPK signaling pathway, which is essential for cell response to diverse stimuli. These variants functionally converge towards the overactivation of the pathway, leading to various constitutional and mosaic conditions. These syndromes show overlapping though distinct clinical presentations and share congenital heart defects, hypertrophic cardiomyopathy (HCM), and lymphatic dysplasia as major clinical features, with highly variable prevalence and severity. Available treatments have mainly been directed to target the symptoms. However, repurposing MEK inhibitors (MEKis), which were originally developed for cancer treatment, to target evolutive aspects occurring in these disorders is a promising option. Animal models have shown encouraging results in treating various RASopathy manifestations, including HCM and lymphatic abnormalities. Clinical reports have also provided first evidence supporting the effectiveness of MEKi, especially trametinib, in treating life-threatening conditions associated with these disorders. Nevertheless, despite notable improvements, there are adverse events that occur, necessitating careful monitoring. Moreover, there is evidence indicating that multiple pathways can contribute to these disorders, indicating a current need to more accurate understand of the underlying mechanism of the disease to apply an effective targeted therapy. In conclusion, while MEKi holds promise in managing life-threatening complications of RASopathies, dedicated clinical trials are required to establish standardized treatment protocols tailored to take into account the individual needs of each patient and favor a personalized treatment. Full article
(This article belongs to the Special Issue New Insights into Pediatric Cardiology)
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11 pages, 4005 KiB  
Review
Surgical Patching in Congenital Heart Disease: The Role of Imaging and Modelling
by Yousef Aljassam, Massimo Caputo and Giovanni Biglino
Life 2023, 13(12), 2295; https://doi.org/10.3390/life13122295 - 2 Dec 2023
Cited by 1 | Viewed by 1154
Abstract
In congenital heart disease, patches are not tailored to patient-specific anatomies, leading to shape mismatch with likely functional implications. The design of patches through imaging and modelling may be beneficial, as it could improve clinical outcomes and reduce the costs associated with redo [...] Read more.
In congenital heart disease, patches are not tailored to patient-specific anatomies, leading to shape mismatch with likely functional implications. The design of patches through imaging and modelling may be beneficial, as it could improve clinical outcomes and reduce the costs associated with redo procedures. Whilst attention has been paid to the material of the patches used in congenital surgery, this review outlines the current knowledge on this subject and isolated experimental work that uses modelling and imaging-derived information (including 3D printing) to inform the design of the surgical patch. Full article
(This article belongs to the Special Issue New Insights into Pediatric Cardiology)
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Figure 1

11 pages, 292 KiB  
Review
An Up-to-Date Literature Review on Ventricular Assist Devices Experience in Pediatric Hearts
by Ștefana Maria Moisă, Alexandru Burlacu, Crischentian Brinza, Eliza Cinteză, Lăcrămioara Ionela Butnariu, Elena Țarcă, Alexandru Florinel Oancea, Ioana-Alecsandra Munteanu, Valentin Munteanu, Laura Stătescu and Laura Mihaela Trandafir
Life 2022, 12(12), 2001; https://doi.org/10.3390/life12122001 - 30 Nov 2022
Cited by 3 | Viewed by 1828
Abstract
Ventricular assist devices (VAD) have gained popularity in the pediatric population during recent years, as more and more children require a heart transplant due to improved palliation methods, allowing congenital heart defect patients and children with cardiomyopathies to live longer. Eventually, these children [...] Read more.
Ventricular assist devices (VAD) have gained popularity in the pediatric population during recent years, as more and more children require a heart transplant due to improved palliation methods, allowing congenital heart defect patients and children with cardiomyopathies to live longer. Eventually, these children may require heart transplantation, and ventricular assist devices provide a bridge to transplantation in these cases. The FDA has so far approved two types of device: pulsatile and continuous flow (non-pulsatile), which can be axial and centrifugal. Potential eligible studies were searched in three databases: Medline, Embase, and ScienceDirect. Our endeavor retrieved 16 eligible studies focusing on five ventricular assist devices in children. We critically reviewed ventricular assist devices approved for pediatric use in terms of implant indication, main adverse effects, and outcomes. The main adverse effects associated with these devices have been noted to be thromboembolism, infection, bleeding, and hemolysis. However, utilizing left VAD early on, before end-organ dysfunction and deterioration of heart function, may give the patient enough time to recuperate before considering a more long-term solution for ventricular support. Full article
(This article belongs to the Special Issue New Insights into Pediatric Cardiology)
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