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Life
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Function, and Dysfunction of the Right Ventricle
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Function, and Dysfunction of the Right Ventricle

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".

Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 2631

Special Issue Editors

Dr. Lincai Ye

E-Mail Website
Guest Editor
Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, National Children’s Medical Center, Shanghai 200127, China
Interests: molecular mechanisms of abnormal hemodynamics in congenital heart disease to regulate the proliferation and maturation of cardiomyocytes
Dr. Haifa Hong

E-Mail Website
Guest Editor
Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, National Children’s Medical Center, Shanghai 200127, China
Interests: cardiology; pediatric cardiac surgery; heart diseases

Special Issue Information

Dear Colleagues,

The Special Issue, edited by Dr. Lincai Ye and Dr. Haifa Hong, will focus on “Function, and Dysfunction of the Right Ventricle”. Recently, the role of the right ventricle (RV) in the field of life science has received more and more attention. The RV serves as a versatile pumping chamber in children with congenital heart disease (CHD). For example, in hypoplastic left heart syndrome and after transposition of the major arteries via atrial inversion operation, RV is not only a pulmonary ventricle, but also a pivotal systemic ventricle. In the field of CHD, RV adaptation is largely determined by the level of exposure to volume overload and pressure overload, which are associated with a distinct clinical course and therapeutic approach. In practice, they often coexist to various degrees. Understanding the functions of the RV and how they are regulated will undoubtedly promote the development of life science and human health. For more information, please refer to: https://www.mdpi.com/journal/life/special_issues/Function, and Dysfunction of the Right Ventricle.

This Special Issue is now open for submissions. Prospective authors should first send a short abstract or tentative title to the Editorial Office. If the editors deem the topic to be appropriate for inclusion in one of the Special Issues, the author will be encouraged to submit a full manuscript.

Dr. Lincai Ye
Dr. Haifa Hong
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (2 papers)

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Research

12 pages, 2801 KiB  
Article
Right Ventricular Myocardial Involvement in Anderson–Fabry Disease at Diagnosis: Evaluation with Three-Dimensional Strain Imaging
by Martina Pucci, Velia Iadevaia, Vittoria Gammaldi, Adelaide Iervolino, Luca Maria Capece, Domenico Sciascia, Vittoria Cuomo, Marina Iacono, Daniele Paoletta, Ciro Santoro and Roberta Esposito
Life 2023, 13(7), 1571; https://doi.org/10.3390/life13071571 - 16 Jul 2023
Viewed by 1111
Abstract
Background: Right ventricular (RV) involvement in Anderson–Fabry disease (AFD) is well known in the advanced stages of the disease RV hypertrophies, but little is known about the early involvement. The aim of our study was to assess RV function in AFD patients [...] Read more.
Background: Right ventricular (RV) involvement in Anderson–Fabry disease (AFD) is well known in the advanced stages of the disease RV hypertrophies, but little is known about the early involvement. The aim of our study was to assess RV function in AFD patients at diagnosis. Methods: A total of 23 AFD patients and 15 controls comparable for age and sex were recruited. A complete 2D standard echo with 3D volumetric and strain analysis of RV was performed. Results: Two patient populations, comparable for clinical baseline characteristics were considered. RV free wall thickness was significantly increased in the AFD group. No significant differences in standard RV indices (TAPSE, transverse diameter, tissue Doppler velocities of the lateral tricuspid annulus) were found. A 3D volumetric analysis showed reduced RV ejection fraction and lower values of longitudinal septal, free wall and global longitudinal strain (GLS) in AFD patients. RV free wall thickness significantly correlated with both free wall RV LS and RV GLS. In multiple linear regression analysis, RV free wall thickness was independently associated with RV GLS even after correction for age and heart rate. Conclusions: In AFD patients, 3D echocardiography allows for the identification of early subclinical functional impairment of RV. RV dysfunction is independently associated with RV hypertrophy. Full article
(This article belongs to the Special Issue Function, and Dysfunction of the Right Ventricle)
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18 pages, 1127 KiB  
Article
Predictors of Pulmonary Hypertension and Right Ventricular Dysfunction in Patients with Hypersensitivity Pneumonitis
by Natalia V. Trushenko, Olga A. Suvorova, Galina V. Nekludova, Iuliia A. Levina, Svetlana Y. Chikina, Alexandra M. Nikolenko, Natalia A. Tsareva, Alexandr V. Volkov, Andrey I. Yaroshetskiy, Zamira M. Merzhoeva, Galiya S. Nuralieva and Sergey N. Avdeev
Life 2023, 13(6), 1348; https://doi.org/10.3390/life13061348 - 08 Jun 2023
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Abstract
Background: Hypersensitivity pneumonitis (HP) is an interstitial lung disease (ILD) that occurs in susceptible individuals in response to various inhaled antigens. The fibrotic phenotype of HP is characterized by disease progression and can lead to pulmonary hypertension (PH). The aim of this study [...] Read more.
Background: Hypersensitivity pneumonitis (HP) is an interstitial lung disease (ILD) that occurs in susceptible individuals in response to various inhaled antigens. The fibrotic phenotype of HP is characterized by disease progression and can lead to pulmonary hypertension (PH). The aim of this study was to estimate the prevalence of PH and to identify predictors of PH in patients with chronic HP. Methods: We conducted an observational longitudinal study that included 85 patients with an established diagnosis of HP. Clinical examination, quality of life questionnaires, high-resolution computed tomography (HRCT) of the chest, arterial blood gases analyses, six-minute walking test (6-MWT), pulmonary function tests, and echocardiography were performed. Results: Patients were divided into groups with fibrotic (71.8%) and nonfibrotic phenotype (28.2%). PH was detected in 41 (48.2%) patients. Patients with PH had the predominant fibrotic phenotype of HP, were older, more symptomatic, and had a higher FVC/DLco ratio. The most significant predictors of PH were CT signs of fibrosis, finger clubbing, FVC/DLco, decreased distance, and SpO2 at the end of 6-MWT, as well as the presence of cardiovascular diseases. Conclusions: PH is a common condition in patients with chronic HP, especially with the fibrotic phenotype. Early detection of the PH predictors is necessary for the timely diagnosis of this complication of HP. Full article
(This article belongs to the Special Issue Function, and Dysfunction of the Right Ventricle)
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