Genome Plasticity and DNA Repair in Candida albicans and Other Related Fungi

Dear Colleagues

Pathogenic fungi cause mucosal and systemic infections that frequently threaten the life lives of immunocompromised patients. Without a functional immune system, antifungal therapy may sometimes be inefficient because of the genetic variability of pathogens. In fact, fungal pathogen resistance to currently used antifungal compounds is increasing all over the world and has become a serious threat to human health. This Special Issue of the Journal of Fungi will bring together experts with an extensive knowledge of the mechanisms that promote genome plasticity and the evolution of pathogenic fungi, with a special emphasis on Candida albicans.

Traditionally, Saccharomyces cerevisiae gave us a stable model for the molecular analysis of DNA repair. However, throughout the last twenty years this area has been extended to commensal and pathogenic fungi, including Ustilago maydis, Aspergillus fumigatus, Cryptococcus sp., and especially C. albicans, the most common human fungal pathogen. Comparative genomic and whole genome sequencing of clinical and natural isolates are powerful tools recently added to classical genetic approaches. With this methodology we can elaborate an exhaustive map of the fungal genome (repetitive sequences, telomeres, centromeres, translocations, indels, aneuploidies and heterozygosity) and analyse how these genomes evolve. Now, we are now closer than ever on our way to decode the secret of fungal pathogen´s evolution.

Prof. Dr. Germán Larriba
Dr. Toni Ciudad
Guest Editors

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