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Recent Advances in Fungal Specialized Metabolism
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Recent Advances in Fungal Specialized Metabolism

A special issue of Journal of Fungi (ISSN 2309-608X). This special issue belongs to the section "Fungal Cell Biology, Metabolism and Physiology".

Deadline for manuscript submissions: closed (30 May 2026) | Viewed by 492

Editors

Dr. Renato Chávez

E-Mail Website
Guest Editor
Departamento de Biología, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago, Chile
Interests: fungal specialized metabolism; fungal biology; cheese-ripening fungi
Special Issues, Collections and Topics in MDPI journals
Dr. Inmaculada Vaca

E-Mail Website
Guest Editor
Departamento de Química, Facultad de Ciencias, Universidad de Chile, Santiago, Chile
Interests: fungal secondary metabolism; natural products; fungi from Antarctica
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Building upon the success of the Special Issue “Recent Advances in Fungal Secondary Metabolism” and its 2nd Edition, we are pleased to announce a new Special Issue: “Recent Advances in Fungal Specialized Metabolism”. This Special Issue aims to highlight the remarkable capabilities of fungi to produce a wide array of specialized metabolites and  structurally diverse natural products that include antibiotics, immunosuppressants, pigments, mycotoxins, siderophores, and other compounds of significant biotechnological relevance.  

This Special Issue of Journal of Fungi invites researchers to contribute original research articles, reviews, and opinion pieces exploring key aspects of fungal specialized metabolism. Topics of  interest include, but are not limited to, the genetic and functional characterization of biosynthetic gene clusters, mechanisms of intra and extracellular transport of specialized metabolites, regulatory networks and transcription control, epigenetic regulation, bioinformatics approaches and genome mining, metabolic engineering and synthetic biology, isolation and structural elucidation of novel fungal specialized metabolites, bioactivity evaluation of purified fungal natural products, and advances in fungal metabolomics.

Dr. Renato Chávez
Dr. Inmaculada Vaca
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Fungi is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • fungal specialized metabolism
  • biosynthetic gene clusters (BGCs)
  • natural products
  • regulatory mechanisms
  • fungal biotechnology
  • metabolomics

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Published Papers (1 paper)

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Research

15 pages, 895 KB  
Article
Amino Acid Depletion Reveals Strain- and Nitrogen Source-Dependent Physiological Responses in Brettanomyces bruxellensis
by Camila G-Poblete, Sandra Moreira-Ramos, Diego Rojas, Nachla Rojas-Torres, Jorge Saavedra and María Angélica Ganga
J. Fungi 2026, 12(9), 636; https://doi.org/10.3390/jof12090636 - 26 Aug 2026
Abstract
Fungal nitrogen metabolism is a central determinant of yeast growth, fermentative performance, and secondary metabolism in fungi associated with fermented environments. For Saccharomyces cerevisiae, the assimilation of nitrogen sources found in grape must, including ammonium, free amino acids, and peptides, has been [...] Read more.
Fungal nitrogen metabolism is a central determinant of yeast growth, fermentative performance, and secondary metabolism in fungi associated with fermented environments. For Saccharomyces cerevisiae, the assimilation of nitrogen sources found in grape must, including ammonium, free amino acids, and peptides, has been widely characterized, establishing a consumption hierarchy in which proline is considered a non-preferential nitrogenous source. However, the regulation and hierarchy of nitrogen-source utilization in non-conventional fungi remain poorly characterized, particularly in yeasts adapted to anthropized fermentative niches. In this context, Brettanomyces bruxellensis represents a useful fungal model to study the different nitrogen sources that are used, strain-dependent physiology, and survival under nutrient-limited fermentative conditions. We hypothesized that apparent depletion of amino acid and the expression of selected amino acid permease genes are strain-dependent traits linked to the survival of B. bruxellensis. In this study, we evaluated the strain-dependent physiology and amino acid depletion patterns of two B. bruxellensis strains from wine (LAMAP2480 and LAMAP1359). In both cases, the highest apparent depletion values under the 20 amino acid condition were observed for arginine, glutamine, tryptophan and proline, indicating that these compounds contributed substantially to the organic nitrogen pool under the assayed conditions. Only LAMAP2480 isolate was able to grow in the condition without added amino acids, indicating strain and nitrogen source dependence under limited organic nitrogen availability. Transcriptional analysis of GAP1, GNP1, and TAT1 permeases showed expression patterns dependent on both the strain and the available nitrogen source. This is the first study to combine the evaluation of physiological performance, amino acid consumption, apparent nitrogen depletion derived from amino acids normalized to OD600 (OD-AA-N depletion), and the transcriptional responses of selected amino acid permease genes. This knowledge may contribute to understanding the survival of B. bruxellensis in fermentation environments with limited nutritional resources. Full article
(This article belongs to the Special Issue Recent Advances in Fungal Specialized Metabolism)
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