Alternative Therapeutic Approaches of Candida Infections

Dear Colleague,

Candida infections are considered a serious public health problem worldwide, especially in immuncompromised patient populations. In addition, the morbidity and mortality rate associated with these infections have not improved significantly over the past few years. The prevalence and incidence of infections caused by Candida species resistant to one or more first-line antifungal(s) has been steadily increasing due to the widespread use of antifungal drugs in agriculture and both veterinary and human medicine. Moreover, biofilm production plays a pivotal role in resistance to traditional antifungals, restricting the proper choice of therapy. As the available antifungal agents are decreasing in efficacy, new innovative approaches have to be implemented in the future in order to eradicate these infections. Alternative therapies involve the administration of combination-based therapies, the usage of antifungal peptides and proteins, plant extracts or natural products, therapies disrupting quorum-sensing, and photodynamic therapy.

Dr. Renátó Kovács
Guest Editor

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