Yeast Cytokinesis

Dear Colleagues,

Cytokinesis partitions cellular constituents from a mother cell into two daughter cells and plays essential roles in cell proliferation, cell differentiation, and tissue homeostasis. Due to powerful genetics, simple genomes, and efficient homologous recombination, both fission yeast and budding yeast have served as premier models for studying the general principles of cytokinesis with unrivaled spatial and temporal resolution. Cytokinesis in yeast can be divided into several critical stages: division site selection, actomyosin contractile ring assembly and constriction, targeted exocytosis for plasma membrane deposition and extracellular matrix (ECM)/cell wall remodeling, and cell separation. These stages are coordinated by conserved signaling pathways, namely the septation initiation network (SIN) in fission yeast and the mitotic exit network (MEN) in budding yeast. Tremendous progress has been made on all aspects of yeast cytokinesis in recent decades. In this Special Issue, we showcase a rich collection of both reviews and original research papers to reflect this progress, while focusing on the discoveries made over the last few years.

Prof. Dr. Jian-Qiu Wu
Prof. Dr. Erfei Bi 
Guest Editors

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