Matrix Remodelling during Development

Dear Colleagues,

The emergence of functional tissue architecture, and the dramatic changes in tissue structure that occur during embryonic morphogenesis, require dynamic remodelling of the extracellular matrix (ECM). Yet our understanding of how cellular activities bring about these changes, how these activities are regulated, and how these regulatory mechanisms have evolved remain frustratingly vague. This Special Issue will focus on new data and novel insights into the remodelling of the extracellular matrix occurring during embryonic development, with emphasis on the underlying molecular mechanisms. We especially encourage submission of studies elucidating activities and regulation of ECM remodelling effectors in vivo, and investigations based on a broad phylogenetic perspective. Both research and review papers are welcome. The objective of this Special Issue is to contribute significantly to a coherent model of how genetically programmed cellular activity cooperatively give rise to meso- and macroscopic tissue organization.

Prof. Dr. Bryan D. Crawford
Guest Editor

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