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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Evolving Landscape of Multiple Sclerosis: New Insights into Biomarkers and Treatment
edited by , and Maddalena Sparaco
submission deadline 25 Apr 2027 | Viewed by 47 | Submission Open
Keywords: multiple sclerosis; precision medicine; biomarkers; neuroimaging; disease-modifying therapies; neurodegeneration; disease progression
(This special issue belongs to the Section Clinical Neurology)
Advances in Cataract, Corneal and Refractive Surgery
edited by , Sheraz M. Daya and Arthur B. Cummings
submission deadline 25 Apr 2027 | Viewed by 38 | Submission Open
Keywords: cataract surgery; corneal surgery; refractive surgery; laser surgery; presbyopia surgery; robotic surgery; cell transplanta-tion; intraocular lens; LASIK; lenticule extraction
(This special issue belongs to the Section Ophthalmology)
Artificial Intelligence in Clinical Radiology Practice: Transforming Medical Imaging and Reporting Workflows
edited by and Amna A. Ajam
submission deadline 25 Apr 2027 | Viewed by 37 | Submission Open
Keywords: artificial intelligence; diagnostic radiology; clinical workflow integration; deep learning image reconstruction; computer-assisted triage; large language models
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Rehabilitation and Treatment of Post-COVID-19 Condition submission deadline 26 Apr 2027 | 2 articles | Viewed by 3009 | Submission Open
Keywords: post-COVID-19 condition; myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS); comorbidities; interdisciplinary; multimodal; digital medicine; rehabilitation; treatment; health-related quality of life; disability; return to work
(This special issue belongs to the Section Clinical Rehabilitation)
Recent Clinical Updates on Movement Disorders
edited by Vladimira Vuletic, Dejan Georgiev and
submission deadline 28 Apr 2027 | Viewed by 97 | Submission Open
Keywords: movement disorders; Parkinson’s disease; dystonia; functional movement disorders; autonomic dysfunction; dysautonomia; deep brain stimulation; non-motor symptoms; neurophysiology; clinical phenotyping
(This special issue belongs to the Section Clinical Neurology)
One Airway, Many Specialists: Multidisciplinary Innovation in Thoraco-Pulmonary Diseases—Insights from the XXIII SIET National Meeting
edited by Federico Raveglia, and
submission deadline 30 Apr 2027 | Viewed by 264 | Submission Open
Keywords: thoraco-pulmonary diseases; endoscopy; thoracic surgery; airway oncology; pleural diseases; mediastinal disorders; digital medicine; artificial intelligence; anesthesiology; radiology; respiratory; diagnosis, treatment and prognosis
(This special issue belongs to the Section Respiratory Medicine)
Current Clinical Research in Oral and Maxillofacial Surgery
edited by
submission deadline 1 May 2027 | Viewed by 5 | Submission Open
Keywords: oral and maxillofacial surgery; microvascular reconstruction; free flap; digital surgical planning; artificial intelligence; head and neck oncology
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Artificial Intelligence (AI) in Dental Clinical Practice
edited by and Keiichiro Watanabe
submission deadline 5 May 2027 | 7 articles | Viewed by 9451 | Submission Open
Keywords: artificial intelligence; dental diagnostics; machine learning; deep learning; digital dentistry; clinical decision support; diagnostic automation; data transparency; evidence-based dentistry
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Rehabilitation Strategies for Chronic Musculoskeletal Pain
edited by Ana Isabel de la Llave Rincon and
submission deadline 10 May 2027 | 2 articles | Viewed by 2936 | Submission Open
Keywords: pain; musculoskeletal; rehabilitation; treatment; classification
(This special issue belongs to the Section Clinical Rehabilitation)
Vascular and Endovascular Surgery: State of the Art and Emerging Insights
edited by Georgios Meimarakis and Volker Ruppert
submission deadline 10 May 2027 | 3 articles | Viewed by 1398 | Submission Open
Keywords: carotid stenosis; peripheral arterial disease; abdominal aortic aneurysm; type B aortic dissection; chronic limb-threatening ischemia; endovascular therapy; vascular surgery; drug-coated balloon; hemodialysis access; health disparities
(This special issue belongs to the Section Vascular Medicine)
Maternal–Fetal Health Monitoring, Prediction and Management of Perinatal Complications
edited by Ioakeim Sapantzoglou and Marianna Theodora
submission deadline 10 May 2027 | Viewed by 103 | Submission Open
Keywords: fetal medicine; prenatal assessment; fetal ultrasound; prenatal genetics; maternal medicine; fetal monitoring; high risk pregnancy
(This special issue belongs to the Section Obstetrics & Gynecology)
Research and Application of Orthopedic Rehabilitation and Ultrasound-Guided Interventional Procedures
edited by Danilo Donati
submission deadline 10 May 2027 | Viewed by 28 | Submission Open
Keywords: orthopaedic rehabilitation; clinical and diagnostical evaluation; clinical physiopathogenesis of muscle; tendon and joint disease; prevention of fall risks; treatment of musculoskeletal disease; ultrasound; interventional procedures; neuropathies
(This special issue belongs to the Section Orthopedics)
Innovations in Clinical Orthodontics submission deadline 14 May 2027 | Viewed by 15 | Submission Open
Keywords: 3D facial analysis; 3D cephalometry; accelerated orthodontics; mini-screws; digital planning; clear aligners; artificial intelligence; craniofacial imaging
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Clinical Advances in the Use of Ultrasound in Critical Care
edited by
submission deadline 15 May 2027 | Viewed by 259 | Submission Open
Keywords: ultrasound; intensive care medicine; shock; hemodymanic monitoring; ARDS
(This special issue belongs to the Section Intensive Care)
Artificial Intelligence and Machine Learning in Cardiovascular Disease: Diagnosis, Risk Stratification, and Prognosis
edited by and Aonghus Lawlor
submission deadline 15 May 2027 | Viewed by 153 | Submission Open
Keywords: artificial intelligence; machine learning; cardiovascular disease; diagnosis; risk prediction; prognosis; tripod+ai; external validation; clinical decision support; predictive modeling
(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Clinical Medicine)
Clinical Intervention in Inflammatory Skin Diseases submission deadline 15 May 2027 | Viewed by 96 | Submission Open
Keywords: inflammatory skin diseases; rosacea; psoriasis; atopic dermatitis; acne; non invasive skin imaging; clinical intervention; laser therapy in dermatology; device-based dermatologic interventions
(This special issue belongs to the Section Dermatology)
Clinical Management in Hand Trauma: Diagnosis, Repair and Rehabilitation submission deadline 19 May 2027 | Viewed by 60 | Submission Open
Keywords: trauma prevention; fractures; nerve injuries; tendon surgery; hand rehabilitation
(This special issue belongs to the Section Orthopedics)
Knee Surgery: Clinical Treatment and Management
edited by Nikolai Ramadanov
submission deadline 20 May 2027 | 2 articles | Viewed by 1024 | Submission Open
Keywords: knee surgery; sports knee injuries; ligament reconstruction; meniscal surgery; cartilage repair; knee osteotomy; knee arthroplasty; clinical outcomes; surgical techniques
(This special issue belongs to the Section Orthopedics)
The Role of Cardiovascular Imaging in Pericardial, Myocardial and Vascular Inflammation submission deadline 20 May 2027 | 1 articles | Viewed by 768 | Submission Open
Keywords: inflammatory cardiovascular disease; pericarditis; myocarditis; inflammatory cardiomyopathy; echocardiography; nuclear techniques; cardiac computed tomography; cardiovascular magnetic resonance; arrhythmia; heart failure
(This special issue belongs to the Section Cardiology)
Cardiac Intensive Care: Clinical Insights and Advances
edited by , and Valentina Bellini
submission deadline 20 May 2027 | 1 articles | Viewed by 766 | Submission Open
Keywords: acute heart failure; artificial intelligence; cardiac intensive care; cardiogenic shock; cardiac surgery; extracorporeal life support; hemodynamic monitoring; machine learning; mechanical circulatory support; outcomes and prognostication; palliative care; postcardiotomy care; precision medicine; resuscitation science; shock management; ventricular assist devices
(This special issue belongs to the Section Intensive Care)
Clinical Management for Metabolic Syndrome and Obesity: 2nd Edition
edited by and Antonio De Arriba-Muñoz
submission deadline 20 May 2027 | 1 articles | Viewed by 450 | Submission Open
Keywords: obesity; metabolic syndrome; hepatic steatosis; diabetes mellitus; children; GLP-1
(This special issue belongs to the Section Endocrinology & Metabolism)
Current Advances in Dysphagia Assessment and Management
edited by
submission deadline 20 May 2027 | 1 articles | Viewed by 394 | Submission Open
Keywords: dysphagia; pathophysiology; swallowing; assessment; swallowing surgery; clinical outcomes
(This special issue belongs to the Section Otolaryngology)
Contemporary Advances in Abdominal Surgery: Precision Care, Digital Innovation, and Future Perspectives
edited by Calin Molnar
submission deadline 20 May 2027 | 1 articles | Viewed by 142 | Submission Open
Keywords: abdominal surgery; precision surgery; digital surgery; artificial intelligence; minimally invasive surgery; surgical oncology; perioperative care
(This special issue belongs to the Section General Surgery)
Modern Clinical Approaches to Cholestic Liver Diseases and Its Complications: Diagnosis, Prognosis, and Treatment
edited by
submission deadline 20 May 2027 | Viewed by 104 | Submission Open
Keywords: cholestatic liver disease; primary biliary cholangitis (PBC); primary sclerosing cholangitis (PSC); portal hypertension; cirrhosis; decompensation; cholangiocarcinoma; hepatocellular carcinoma
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Advanced Technologies in Prenatal Screening and Maternal Fetal Medicine
edited by Jeffrey Denney, Joshua Nitsche and Matthew Zuber
submission deadline 20 May 2027 | Viewed by 102 | Submission Open
Keywords: prenatal diagnosis; prenatal genetic testing; carrier screening; advances in fetal care; advances in prenatal ultrasound
(This special issue belongs to the Section Obstetrics & Gynecology)
Innovations in Endovascular Treatment of Thoracic, Thoracoabdominal and Abdominal Aortic Aneurysms
edited by , Enrico Gallitto and
submission deadline 20 May 2027 | Viewed by 97 | Submission Open
Keywords: endovascular aortic repair; TEVAR; EVAR; fenestrated endovascular repair; branched endovascular repair; aortic arch repair; physician-modified endograft; hostile neck anatomy; clinical application of 3D printing; artificial intelligence; aortic remodelling; robotic aortic surgery
(This special issue belongs to the Section Vascular Medicine)
Surgical Management of Brain–Spinal Cord–Nerve Axis Disorders
edited by Ismail Zaed
submission deadline 20 May 2027 | Viewed by 95 | Submission Open
Keywords: neurosurgery; brain disorders; spinal cord pathology; peripheral nerve disorders; surgical management
(This special issue belongs to the Section Clinical Neurology)
Clinical Advances in Multidisciplinary Emergency and Acute Disease Management: Risk, Triage and Clinical Strategies to Improve Patient Outcomes
edited by Aikaterini Apostolopoulou
submission deadline 20 May 2027 | Viewed by 93 | Submission Open
Keywords: emergency medicine; acute care; risk stratification; triage; patient outcomes
(This special issue belongs to the Section Emergency Medicine)
Rhinitis and Rhinosinusitis: Advances in Biomarker Discovery and Therapeutic Innovation
edited by Lara Derycke
submission deadline 20 May 2027 | Viewed by 92 | Submission Open
Keywords: rhinitis; rhinosinusitis; chronic rhinosinusitis; nasal polyps; nasal surgery; precise medicine; biomarker
(This special issue belongs to the Section Otolaryngology)
Strategies and Outcomes in Complex Cardiac Surgery
edited by Mohammed Morjan, Mateo Marin-Cuartas and Carlos Alberto Mestres
submission deadline 20 May 2027 | Viewed by 90 | Submission Open
Keywords: complex cardiac surgery; infective endocarditis; aortic dissection; aortic arch surgery; surgical innovation; hybrid pro-cedures; cerebral protection; surgical outcomes
(This special issue belongs to the Section Cardiology)
Outcome Measurement and Prediction in Spine Surgery
edited by and Il Choi
submission deadline 20 May 2027 | Viewed by 90 | Submission Open
Keywords: patient-reported outcome measures; spine surgery; endoscopic spine surgery; minimally invasive spine surgery; outcome prediction; machine learning; electronic PROM; measurement timing; patient expectations; clinical outcomes; AI; predictive modeling
(This special issue belongs to the Section Clinical Neurology)
Thoracolumbar Spine Injuries: Current Concepts and Future Directions submission deadline 20 May 2027 | Viewed by 89 | Submission Open
Keywords: thoracolumbar spine trauma; burst fracture; AO Spine classification; clinical trials; epidemiology; sex and gender; Hounsfield units; artificial intelligence; minimally invasive surgery; individualized care
(This special issue belongs to the Section Orthopedics)
Advances in Acute and Intermediate Critical Care: Management and Monitoring of High-Risk Medical Patients
edited by
submission deadline 20 May 2027 | Viewed by 83 | Submission Open
Keywords: intermediate care unit; critical care; emergency medicine; acute care; high-risk patients; sepsis; acute respiratory failure; non-invasive ventilation; hemodynamic monitoring; artificial intelligence; clinical decision support; point-of-care ultrasound; risk stratification; patient monitoring; critical illness
(This special issue belongs to the Section Emergency Medicine)
Lower Urinary Tract Symptoms and Benign Prostatic Hyperplasia (BPH): From Prevention to Diagnosis to Cure
edited by Ilias Giannakodimos
submission deadline 20 May 2027 | Viewed by 78 | Submission Open
Keywords: BPH; LUTS; minimally invasive surgery; diagnosis; treatment; prostate
(This special issue belongs to the Section Reproductive Medicine & Andrology)
Recent Clinical Advances in Endodontics
edited by Carlo Gaeta and
submission deadline 20 May 2027 | Viewed by 76 | Submission Open
Keywords: root canal treatment; endodontics; systemic diseases and apical periodontitis; irrigation; risk factors; new antimicrobial peptides; regenerative endodontics
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Radiology and Nuclear Medicine for Precision Medical Care: Bridging Innovation from Bench to Patient
edited by
submission deadline 20 May 2027 | Viewed by 76 | Submission Open
Keywords: radiology; precision medicine; diagnostic imaging; emergency radiology; computed tomography (CT); magnetic resonance imaging (MRI); multimodality imaging; quantitative imaging; imaging biomarkers; oncologic imaging; cancer imaging; prostate cancer imaging; renal tumors; pulmonary embolism; thoracic imaging; chest imaging; cardiac CT; abdominal imaging; trauma
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Recent Advances in Imaging and Interventional Techniques for Prostate Cancer
edited by Francesco Ziglioli and Umberto Vittorio Maestroni
submission deadline 20 May 2027 | Viewed by 75 | Submission Open
Keywords: prostate cancer; pobotic-assisted and focal therapies; artificial intelligence; radiomics image-guided interventions; multiparametric MRI; PSMA-PET/CT
(This special issue belongs to the Section Nephrology & Urology)
Clinical Treatment and Management of Rheumatic Diseases, Autoinflammatory Diseases and Autoimmune Disorders: 2nd Edition
edited by Merav Lidar and
submission deadline 20 May 2027 | Viewed by 75 | Submission Open
Keywords: rheumatic diseases; autoinflammatory diseases; autoimmune disorders; rheumatoid arthritis; diagnosis
(This special issue belongs to the Section Immunology & Rheumatology)
Advances in Ultrasound Imaging for Pulmonary Diseases
edited by Natalia Buda and
submission deadline 20 May 2027 | Viewed by 70 | Submission Open
Keywords: lung ultrasound; thoracic ultrasound; POCUS; respiratory medicine; interstitial lung diseases; pneumonia; acute respiratory failure; pleural diseases; pulmonary edema; pulmonary embolism; interventional pulmonology; critical care; heart failure; artificial intelligence
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Next-Generation Approaches to Out-of-Hospital Cardiac Arrest: From Triage to Post-Resuscitation Care
edited by Young Sun Ro, and Seok-Jin Ryu
submission deadline 20 May 2027 | Viewed by 70 | Submission Open
Keywords: out-of-hospital cardiac arrest; resuscitation; field triage; predictive modeling; artificial intelligence; digital healthcare; post-resuscitation care; neuroprognostication
(This special issue belongs to the Section Emergency Medicine)
Innovations and Clinical Advances in Endovascular Neurosurgery
edited by
submission deadline 20 May 2027 | Viewed by 68 | Submission Open
Keywords: endovascular neurosurgery; mechanical thrombectomy; intracranial aneurysm; flow diversion; arteriovenous malformation; acute ischemic stroke; neurointervention; cerebrovascular disease; minimally invasive techniques; neuroimaging
(This special issue belongs to the Section Clinical Neurology)
Renal Inflammation and Fibrosis and Retroperitoneal Fibroinflammatory Diseases: Molecular Mechanisms, Clinical Challenges, and Emerging Therapies
edited by
submission deadline 20 May 2027 | Viewed by 66 | Submission Open
Keywords: retroperitoneal fibrosis, renal fibrosis; IgG4-related disease (IgG4-RD); Erdheim-Chester Disease; lupus nephritis; systemic vasculitis; chronic periaortitis; chronic tubulointerstitial nephritis; obstructive nephropathy; fibroinflam-matory disorders; antifibrotic therapies; biomarkers
(This special issue belongs to the Section Nephrology & Urology)
Current Advances and Insights in Chronic Pain Management
edited by Héctor García-López
submission deadline 20 May 2027 | Viewed by 66 | Submission Open
Keywords: chronic pain management; musculoskeletal pain; fibromyalgia; physiotherapy interventions; rehabilitation; therapeutic exercise; physical agents; dry needling; manual therapy; pain neuroscience education; virtual reality-based rehabilitation; telerehabilitation; non-pharmacological interventions; randomized controlled trials; systematic reviews and meta-analyses
(This special issue belongs to the Section Clinical Neurology)
Obstructive Sleep Apnoea: Risk Factors, Associated Disorders, and Variability in Disease Severity
edited by Amro Daboul
submission deadline 20 May 2027 | Viewed by 66 | Submission Open
Keywords: obstructive sleep apnoea; interdisciplinary sleep medicine; risk factors; associated disorders; disease severity
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Gynecological Cancers and Precancerous Lesions: Diagnosis and Treatment for Better Outcomes
edited by Demetra Gabriela Socolov
submission deadline 20 May 2027 | Viewed by 63 | Submission Open
Keywords: gynecological cancers; precancerous lesions; HPV infection; cervical intraepithelial neoplasia; biomarkers; epigenetics; microbiota; molecular diagnostics; IOTA; IETA
(This special issue belongs to the Section Obstetrics & Gynecology)
Aortic Dissection: Clinical Diagnosis and Treatment for Better Outcomes
edited by Ilaria Franzese and Daniele Linardi
submission deadline 20 May 2027 | Viewed by 62 | Submission Open
Keywords: aortic imaging; aortic surgery; endovascular treatment; aortic dissection; cerebral perfusion; aortic valve
(This special issue belongs to the Section Cardiology)
Application of Imaging in Liver Diseases
edited by Hideaki Ishida
submission deadline 20 May 2027 | Viewed by 62 | Submission Open
Keywords: liver; ultrasound; imaging; fibrosis; gastroenterology; digestive system diseases; hepatology; cholecystitis; hepatocellular carcinoma; chronic liver disease
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Current Perspectives on Coronary Artery Disease
edited by
submission deadline 20 May 2027 | Viewed by 61 | Submission Open
Keywords: ischemic heart disease; coronary artery disease; prevention strategies; treatment options; multidisciplinary approach; interven-tional cardiology; research lines; bifurcation lesions; chronic total occlusion
(This special issue belongs to the Section Cardiology)
Cardiac Ablation: Emerging Technologies, Techniques, and Clinical Evidence
edited by and Mariusz Kowalewski
submission deadline 20 May 2027 | Viewed by 59 | Submission Open
Keywords: atrial fibrillation; arrhythmia; hybrid ablation; electrophysiology; cardiac surgery; pulsed field ablation; cardiac anatomy
(This special issue belongs to the Section Cardiology)
Contemporary Approaches to Heart Failure: Diagnosis and Therapy
edited by
submission deadline 20 May 2027 | Viewed by 59 | Submission Open
Keywords: heart failure; SGLT2 inhibitors; pulmonary hypertension; ATTR-CM; transcatheter structural intervention
(This special issue belongs to the Section Cardiology)
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