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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Attention-Deficit–Hyperactivity Disorder (ADHD): Bridging Theory and Clinical Application
edited by Rafał R. Jaeschke
submission deadline 25 Sep 2025 | Viewed by 134 | Submission Open
Keywords: ADHD; emotional dysregulation; diagnosis and assessment; pharmacological and non-pharmacological treatments; neurobiology; comorbidities
(This special issue belongs to the Section Mental Health)
Clinical Management of Complications Following Kidney Transplant Surgery
edited by Ryoichi Imamura
submission deadline 25 Sep 2025 | Viewed by 128 | Submission Open
Keywords: kidney transplantation; complication; rejection; infectious disease; de novo cancer; cardiovascular disease; biomarkers
(This special issue belongs to the Section Nephrology & Urology)
Treatment Strategies for Prostate Cancer: An Update submission deadline 25 Sep 2025 | Viewed by 108 | Submission Open
Keywords: prostate cancer; robotic surgery; uro-oncology; focal therapy; single-port; radiotherapy
(This special issue belongs to the Section Nephrology & Urology)
Clinical Advances and Challenges in Laparoscopic Surgery
edited by Leonid Barkhatov
submission deadline 25 Sep 2025 | Viewed by 97 | Submission Open
Keywords: laparoscopic surgery; minimally invasive surgery; surgical outcomes; oncologic surgery; general surgery; learning curve
(This special issue belongs to the Section General Surgery)
Clinical Application of Artificial Intelligence in Vascular Surgery
edited by
submission deadline 25 Sep 2025 | Viewed by 95 | Submission Open
Keywords: artificial intelligence; machine learning; vision; vascular imaging; natural language processing; innovation; vascular surgery; vascular diseases; endovascular; aortic disease; carotid disease; peripheral artery disease; venous disease
(This special issue belongs to the Section Vascular Medicine)
State of the Art in Clinical Management of Sedation and Anesthesia Challenges
edited by Basavana Goudra
submission deadline 25 Sep 2025 | Viewed by 76 | Submission Open
Keywords: anesthesia; oxygenation; sedative agents; ventilation; airway management
(This special issue belongs to the Section Anesthesiology)
Vascular and Endovascular Surgery: Current Progress and Future Challenges
edited by Michael Keese and Martin Sigl
submission deadline 28 Sep 2025 | 5 articles | Viewed by 4873 | Submission Open
Keywords: vascular; endovascular; surgery; therapy; aneurysm; vascular; PAD; venous; interdisciplinary
(This special issue belongs to the Section Vascular Medicine)
New Perspectives in Liver Transplantation and Biliary Complications
edited by and Francesco Frongillo
submission deadline 28 Sep 2025 | 3 articles | Viewed by 3178 | Submission Open
Keywords: liver transplant; cholangiopathy; ischemia/reperfusion injury; machine perfusion; extended-criteria donors
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Echocardiographic Imaging in Transcatheter Structural Intervention: Current Practices and Future Directions
edited by and Fausto Pizzino
submission deadline 28 Sep 2025 | 2 articles | Viewed by 2989 | Submission Open
Keywords: echocardiographic imaging; transcatheter intervention; aortic stenosis; mitral regurgitation; tricuspid regurgitation; left atrial appendage closure; patent foramen ovale closure; atrial septal defect repair
(This special issue belongs to the Section Cardiology)
High-Flow Nasal Cannula (HFNC) and Noninvasive Ventilation: What Is New in Acute, Chronic and Rehabilitation Settings? submission deadline 28 Sep 2025 | 1 articles | Viewed by 1836 | Submission Open
Keywords: NIV; HFNC; noninvasive ventilation; acute respiratory insufficiency; chronic respiratory insufficiency
(This special issue belongs to the Section Respiratory Medicine)
Clinical Management and Treatment of Orthopedic Oncology: 2nd Edition
edited by and Danielle Elizabeth Greig
submission deadline 28 Sep 2025 | 2 articles | Viewed by 1420 | Submission Open
Keywords: bone metastasis; primary bone tumors; soft tissue sarcoma; limb salvage; multimodal treatment strategies
(This special issue belongs to the Section Orthopedics)
Current Progress in the Treatment of Cornea and Ocular Surface Diseases
edited by Marco Messina and
submission deadline 28 Sep 2025 | 2 articles | Viewed by 1269 | Submission Open
Keywords: dry eye disease; meibomian gland dysfunction; microbial keratitis; auto-immune keratitis; peripheral ulcerative keratitis; neurotrophic keratopathy; corneal dystrophies; corneal degenerations; mucous membrane pemphigoid; ocular cicatricial disease; Stevens– Johnson syndrome; pterygium; ocular graft-versus-host disease; limbal stem cell deficiency; keratoplasty; amniotic membrane transplantation; keratoconus; corneal collagen cross-linking; antimicrobial therapy; corneal neurotization; vernal keratoconjunctivitis; atopic keratoconjunctivitis
(This special issue belongs to the Section Ophthalmology)
Advances in the Diagnosis, Treatment of Intestinal Cancer: 2nd Edition
edited by and
submission deadline 28 Sep 2025 | Viewed by 127 | Submission Open
Keywords: colorectal cancer; early detection; treatment; immune therapy; radiation therapy; chemotherapy; risk factors; improved prognosis
(This special issue belongs to the Section Oncology)
New Advances in COVID-19 and Pregnancy
edited by
submission deadline 30 Sep 2025 | 12 articles | Viewed by 18632 | Submission Open
Keywords: COVID-19 and pregnancy; SARS-CoV-2 infection; maternal mortality and morbidity; pregnancy complication; management protocol; maternal comorbidities; severe disease; prevention; diagnosis; treatment; management
(This special issue belongs to the Section Obstetrics & Gynecology)
Orthodontics: Current Advances and Future Options submission deadline 30 Sep 2025 | 13 articles | Viewed by 16042 | Submission Open
Keywords: digital orthodontics; functional devices; cranial growth; orthodontic therapy; customized devices
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Atrial Fibrillation and Its Complications: Preventive Strategies and Relative Evidence
edited by Roberto Galea
submission deadline 30 Sep 2025 | 9 articles | Viewed by 14730 | Submission Open
Keywords: atrial fibrillation; catheter ablation; oral anticoagulation; left atrial appendage closure; stroke prevention
(This special issue belongs to the Section Cardiology)
New Insights into Pancreatic Surgery
edited by Mario Serradilla-Martín and José Manuel Ramia
submission deadline 30 Sep 2025 | 5 articles | Viewed by 9279 | Submission Open
Keywords: pancreas; pancreatectomy; surgery; outcomes; cancer; fistula; minimally invasive surgery; IPMT
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Clinical Advances in Malaria
edited by Marc Thellier
submission deadline 30 Sep 2025 | 2 articles | Viewed by 9164 | Submission Open
Keywords: malaria; diagnosis; treatment; vaccination; resistance; epidemiology; public health
(This special issue belongs to the Section Infectious Diseases)
Diagnosis, Treatment, and Prevention of Glaucoma: Second Edition submission deadline 30 Sep 2025 | 7 articles | Viewed by 8553 | Submission Open
Keywords: glaucoma; OCT; visual field; blindness; glaucoma surgery; intraocular pressure; glaucoma prevention; glaucoma treatment
(This special issue belongs to the Section Ophthalmology)
Recent Advances in Facial Palsy Management
edited by
submission deadline 30 Sep 2025 | 3 articles | Viewed by 8544 | Submission Open
Keywords: facial palsy; transplantation; facial cybernetics; facial therapy; nerve supermicrosurgery
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Chronic Kidney Disease: Clinical Challenges and Management submission deadline 30 Sep 2025 | 5 articles | Viewed by 6445 | Submission Open
Keywords: chronic kidney disease; clinical trial; end-stage renal disease; kidney dysfunction; management; challenge
(This special issue belongs to the Section Nephrology & Urology)
Musculoskeletal Disorders: Clinical Diagnosis, Treatment and Rehabilitation submission deadline 30 Sep 2025 | 4 articles | Viewed by 6396 | Submission Open
Keywords: musculoskeletal disorders; therapeutic exercise; functional evaluation; rehabilitation protocols; musculoskeletal ultrasound; biomechanical aná lisis; quality of life; functional assessment of the musculoskeletal system; strength training; physical therapy; morphofunctional assessment; conservative treatments; range of motion evaluation; randomized controlled trials
(This special issue belongs to the Section Clinical Rehabilitation)
Clinical Diagnosis of Lung Cancer
edited by Andrea Bille and
submission deadline 30 Sep 2025 | 5 articles | Viewed by 6254 | Submission Open
Keywords: biomarkers; bronchoscopy; diagnosis; imaging; liquid biopsy; lung cancer; mediastinoscopy; minimally invasive surgery; pathology; screening; staging
(This special issue belongs to the Section Respiratory Medicine)
Dental Implantology: Clinical Updates and Perspectives
edited by
submission deadline 30 Sep 2025 | 6 articles | Viewed by 5650 | Submission Open
Keywords: dental implantology; reconstructive surgery; biomaterials; tissue engineering; regenerative medicine; digital dentistry; perimplantitis; peri-implant soft tissues
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Geriatric Diseases: Management and Epidemiology
edited by
submission deadline 30 Sep 2025 | 5 articles | Viewed by 5288 | Submission Open
Keywords: ageing and health; older care; chronic diseases; preventive health strategies; multidisciplinary approaches; health inequalities; innovation in care; global ageing challenges; epidemiology of ageing; quality of life in older adults
(This special issue belongs to the Section Geriatric Medicine)
Innovation in Hand Surgery
edited by Rocco De Vitis and Marco Passiatore
submission deadline 30 Sep 2025 | 6 articles | Viewed by 4594 | Submission Open
Keywords: hand surgery; hand reconstruction; hand deformities; reconstructive surgery; peripheral nerve surgery; hand tumors; thumb arthritis; wrist arthritis; arthroscopy; prosthesis
(This special issue belongs to the Section Orthopedics)
Current Advances in Aortic Valve Stenosis
edited by
submission deadline 30 Sep 2025 | 4 articles | Viewed by 4328 | Submission Open
Keywords: valvular heart diseases; aortic stenosis; prevention; diagnosis; management
(This special issue belongs to the Section Cardiology)
Clinical Advances in Ischemic Heart Disease
edited by Stefano Schena and
submission deadline 30 Sep 2025 | 2 articles | Viewed by 4184 | Submission Open
Keywords: multidisciplinary approach; modern imaging; myocardial pre-habilitation; revascularization in severe ischemic cardiomyopathy; guidelines; complex PCI; hybrid treatment; minimally invasive surgery
(This special issue belongs to the Section Cardiology)
Gastrointestinal Endoscopy: Clinical Advances in Diagnosis and Treatment, 2nd Edition
edited by Joao Santos-Antunes and
submission deadline 30 Sep 2025 | 2 articles | Viewed by 4127 | Submission Open
Keywords: diagnostic endoscopy; therapeutic endoscopy; gastrointestinal neoplasia; endoscopic mucosal resection; endoscopic submucosal dissection; early cancer; subepithelial lesions
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Clinical Management for Metabolic Syndrome and Obesity
edited by and Antonio De Arriba-Muñoz
submission deadline 30 Sep 2025 | 4 articles | Viewed by 3799 | Submission Open
Keywords: obesity; metabolic syndrome; estatosis hepatic; diabetes mellitus; children; GLP-1
(This special issue belongs to the Section Endocrinology & Metabolism)
Causes and Advanced Treatments of Macular Edema submission deadline 30 Sep 2025 | 3 articles | Viewed by 3673 | Submission Open
Keywords: macular edema; laser photocoagulation; subthreshold laser; anti-VEGF; optical coherence tomography; fluorescein angiography; angio-OCT
(This special issue belongs to the Section Ophthalmology)
Advancements in Venous Disease Management: From Conservative to Interventional Treatments
edited by and Chiara Lomazzi
submission deadline 30 Sep 2025 | 2 articles | Viewed by 3642 | Submission Open
Keywords: chronic venous disease; varicose veins; venoactive drugs; saphenous vein; venous stent; iliac vein; compression therapy; venous insufficiency
(This special issue belongs to the Section Vascular Medicine)
Toward Improved Evaluation, Treatment, and Management of Movement Disorders and Cognitive Impairments in People with Cerebral Palsy
edited by Elegast Monbaliu and
submission deadline 30 Sep 2025 | 4 articles | Viewed by 3606 | Submission Open
Keywords: cerebral palsy; movement disorders; cognition; technology; artificial intelligence; wearables; neuroimaging; telehealth
(This special issue belongs to the Section Clinical Neurology)
Renal Cell Carcinoma: From Diagnostic to Therapy
edited by Ithaar H. Derweesh and Zachary A. Hamilton
submission deadline 30 Sep 2025 | 3 articles | Viewed by 3293 | Submission Open
Keywords: biomarkers; clinical practice patterns; diagnosis; kidney cancer; metastasis; renal cell carcinoma; renal mass; staging; systemic therapy; surveillance
(This special issue belongs to the Section Nephrology & Urology)
Artificial Intelligence and Eye Disease submission deadline 30 Sep 2025 | 4 articles | Viewed by 3268 | Submission Open
Keywords: Artificial Intelligence; machine learning; deep learning; ophthalmology; eye disease; eye disorder
(This special issue belongs to the Section Ophthalmology)
The Challenges and Prospects in Cochlear Implantation submission deadline 30 Sep 2025 | 3 articles | Viewed by 3137 | Submission Open
Keywords: cochlear implant; hearing loss; image; modeling; cognition; electrophysiology; AI; big data; interdisciplinary assessment
(This special issue belongs to the Section Otolaryngology)
Clinical Advances in Breast Reconstruction: Treatment and Management
edited by Eric I-Yun Chang
submission deadline 30 Sep 2025 | 3 articles | Viewed by 2821 | Submission Open
Keywords: breast reconstruction; aesthetic breast surgery; robotic surgery; microsurgery; alloplastic breast reconstruction; autologous breast reconstruction
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Improving Diagnosis and Treatment of Vestibular Disorder: Latest Advances and Challenges
edited by , and Athanasia Korda
submission deadline 30 Sep 2025 | 2 articles | Viewed by 2792 | Submission Open
Keywords: vestibular system; balance disorders; dizziness; vertigo; vestibular testing; videonystagmography; video head impulse test; vestibular evoked myogenic potentials; vestibular rehabilitation therapy
(This special issue belongs to the Section Otolaryngology)
Advanced Strategy for Diagnosis and Treatment of Obstructive Sleep Apnea Syndrome (OSAS)
edited by
submission deadline 30 Sep 2025 | 2 articles | Viewed by 2628 | Submission Open
Keywords: obstructive sleep apnea syndrome; diagnosis; obesity; treatment; CPAP; comorbidities; cardiovascular risk
(This special issue belongs to the Section Respiratory Medicine)
Multiple Sclerosis and Demyelinating Diseases: Diagnosis, Treatment and Prognosis
edited by Alberto Gajofatto
submission deadline 30 Sep 2025 | 1 articles | Viewed by 2285 | Submission Open
Keywords: multiple sclerosis; neuromyelitis optica; MOG-antibody disease; diagnosis; prognosis; treatment
(This special issue belongs to the Section Clinical Neurology)
Clinical Management of Movement Disorders (Second Edition)
edited by
submission deadline 30 Sep 2025 | 2 articles | Viewed by 2270 | Submission Open
Keywords: Parkinson’ s disease; parkinsonism; tremor; tic; dystonia; chorea; athetosis; ballism; myoclonus; ataxia; diagnosis; symptom monitoring; treatments
(This special issue belongs to the Section Clinical Neurology)
Innovations in Head and Neck Surgery
edited by and Giovanni Badiali
submission deadline 30 Sep 2025 | 1 articles | Viewed by 2204 | Submission Open
Keywords: reconstructive surgery; head and neck surgery; 3D printing; new technologies; virtual surgical planning; computer-assisted surgery; personalized reconstructive surgery; patient-specific implants; augmented reality; artificial intelligence; robotic surgery; surgical navigation
(This special issue belongs to the Section Otolaryngology)
Clinical and Surgical Updates on Bariatric Surgery submission deadline 30 Sep 2025 | 1 articles | Viewed by 2184 | Submission Open
Keywords: bariatric surgery; morbid obesity; sleeve gastrectomy; gastric bypass; surgical complications; diabetes remission; hypertension remission; hypercholesterolemia remission; GERD; de novo GERD
(This special issue belongs to the Section General Surgery)
Innovative Approaches to Upper Limb Rehabilitation in Orthopaedics: Advances in Functional Recovery and Pain Management
edited by and Danilo Donati
submission deadline 30 Sep 2025 | 1 articles | Viewed by 2088 | Submission Open
Keywords: upper limb rehabilitation; orthopaedics; musculoskeletal disorders; functional recovery; pain management
(This special issue belongs to the Section Orthopedics)
Periodontal and Other Associated Oral Diseases: Diagnosis and Management in the Context of Systemic Pathology, 2nd Edition submission deadline 30 Sep 2025 | 3 articles | Viewed by 1900 | Submission Open
Keywords: periodontitis; oral diseases; periimplantitis; biomarkers; cytokines; oxidative stress markers; PCR test; point-of-care test; CBCT; periodontal treatment; immunomodulatory therapy; local drug delivery
(This special issue belongs to the Section Otolaryngology)
Experience and New Application in Otolaryngology and Maxillofacial Surgery
edited by Riccardo Nocini
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1625 | Submission Open
Keywords: new surgical techniques; robotics; endoscopy; revascularized free flaps; innovation; 3D surgical planning.
(This special issue belongs to the Section Otolaryngology)
Mitral and Tricuspid Valve Disease and Imaging Techniques—2nd Edition
edited by and Annalisa Pasquini
submission deadline 30 Sep 2025 | 2 articles | Viewed by 1609 | Submission Open
Keywords: imaging in valvular heart disease; mitral valve disease; tricuspid valve disease; computed tomography; echocardiography; transesophageal echocardiography; cardiac magnetic resonance imaging; cardiac surgery; structural interventional cardiology; multi-modality imaging
(This special issue belongs to the Section Cardiovascular Medicine)
Targeted Diagnosis and Treatment of Coronary Artery Disease: 2nd Edition
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1541 | Submission Open
Keywords: coronary artery disease; myocardial revascularization; percutaneous coronary intervention; cardiac surgery; coronary artery bypass graft; intravascular ultrasound; fractional flow reserve; instantaneous wave-free ratio; angiogenesis
(This special issue belongs to the Section Cardiology)
Artificial Intelligence, Computer Modeling and Technology: Clinical Changing Practice in Reconstructive Surgery submission deadline 30 Sep 2025 | 1 articles | Viewed by 1385 | Submission Open
Keywords: reconstructive surgery; plastic surgery; breast surgery; breast reconstruction; oncologic surgery
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Clinical Medicine and Surgery in the Digital Age: Advances in Virtual, Augmented, Mixed, and Extended Reality
edited by Mohsen Annabestani and
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1379 | Submission Open
Keywords: virtual reality (VR); augmented reality (AR); mixed reality (MR); extended reality (XR); clinical medicine; surgery; diagnostic accuracy; surgical outcome; patient care; medical training
(This special issue belongs to the Section General Surgery)
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