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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Retinal Diseases: Recent Advances in Diagnosis and Treatment—2nd Edition
edited by Dario Giorgio and Dario Pasquale Mucciolo
submission deadline 20 Aug 2026 | Viewed by 67 | Submission Open
Keywords: retinal diseases; retinal degeneration; macular degeneration; OCT; retinal imaging
(This special issue belongs to the Section Ophthalmology)
Precision Neuroimaging in Mental and Behavioral Health Research
edited by Thomas Vanicek and Arkadiusz Komorowski
submission deadline 20 Aug 2026 | Viewed by 63 | Submission Open
Keywords: psychiatry; neuroimaging; addiction; substance use disorders (SUD); attention deficit hyperactivity disorder (ADHD); imaging genomics; imaging transcriptomics
(This special issue belongs to the Section Mental Health)
The Liver–Kidney Axis in Metabolic Diseases: Biomarkers and Clinical Implications
edited by
submission deadline 20 Aug 2026 | Viewed by 63 | Submission Open
Keywords: liver; kidney; cross-organ crosstalk; mechanisms; biomarkers; metabolic diseases; clinical implications
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Recent Advances in Hypercholesterolemia
edited by Ana Catarina Alves
submission deadline 20 Aug 2026 | Viewed by 61 | Submission Open
Keywords: hypercholesterolemia; cardiovascular risk; molecular diagnostics; variants of uncertain significance (VUS); functional characterisation; precision medicine; lipid-lowering therapy
(This special issue belongs to the Section Endocrinology & Metabolism)
Breaking the Barrier: Early Detection of Pancreatic Ductal Adenocarcinoma (PDAC) submission deadline 20 Aug 2026 | Viewed by 61 | Submission Open
Keywords: pancreatic ductal adenocarcinoma (PDAC); pancreatic cancer; IPMN; PDAC screening; early PDAC detection; PDAC biomarkers; CT; NMR
(This special issue belongs to the Section Oncology)
Clinical Approaches of Intracranial Aneurysm and Subarachnoid Hemorrhage
edited by Sylvia Bele
submission deadline 20 Aug 2026 | Viewed by 60 | Submission Open
Keywords: aSAH; clipping or coiling; extracranial complications; cerebral vasospasm; ICU treatment
(This special issue belongs to the Section Clinical Neurology)
Clinical Advances in Orthopedic Infections: 2nd Edition
edited by
submission deadline 20 Aug 2026 | Viewed by 59 | Submission Open
Keywords: orthopedic surgery; orthopedic infections; periprosthetic joint infection; surgical site infection; infection management
(This special issue belongs to the Section Orthopedics)
Clinical Advances in Hearing Loss: Diagnosis, Treatment, and Management submission deadline 20 Aug 2026 | Viewed by 59 | Submission Open
Keywords: hearing loss; deafness; bone conduction implants; middle ear implants; cochlear implants; myringoplasty; tympanoplasty; stapedotomy; ossicular chain reconstruction; imaging; audiological diagnostic
(This special issue belongs to the Section Otolaryngology)
Therapeutic Advances and Emerging Treatments in Inflammatory Bowel Disease
edited by
submission deadline 20 Aug 2026 | Viewed by 58 | Submission Open
Keywords: inflammatory bowel disease; therapeutic advances emerging treatments; biologics and small molecules; precision medicine in IBD; pharmacokinetic model
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Current Concepts and Technological Innovations in Hepato-Pancreato-Biliary Surgery and Transplantation
edited by Michele Finotti and Francesco D’Amico
submission deadline 20 Aug 2026 | Viewed by 58 | Submission Open
Keywords: hepato-pancreato-biliary surgery; hepato-pancreato-biliary transplantation; pancreatic cancer; hepatobiliary cancer; vascular reconstruction; minimally invasive in hepato-pancreato-biliary surgery; robotic techniques; organ-preservation strategies
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Updates on Neuromuscular Diseases
edited by
submission deadline 20 Aug 2026 | Viewed by 57 | Submission Open
Keywords: neuromuscualr disorders; myopathies; neuropathies; neuromuscualr junction disorders; neurogenetics
(This special issue belongs to the Section Clinical Neurology)
Anesthesia and Intensive Care: Clinical Practices and Prospects
edited by
submission deadline 20 Aug 2026 | Viewed by 54 | Submission Open
Keywords: artificial intelligence; clinical decision support; perioperative risk stratification; perioperative patient safety; hemodynamic optimization
(This special issue belongs to the Section Intensive Care)
Orthopaedic Trauma and Bone Healing: Recent Advances and Future Perspectives
edited by Gheorghe Tomoaia and Daniel Oltean-Dan
submission deadline 20 Aug 2026 | Viewed by 52 | Submission Open
Keywords: orthopaedic trauma; fractures; minimally invasive fixation; bone healing; biomaterials; periprosthetic fractures; artificial intelligence; rehabilitation; complications; orthopaedic surgery
(This special issue belongs to the Section Orthopedics)
Clinical Perspectives on Extracorporeal Membrane Oxygenation (ECMO)
edited by
submission deadline 20 Aug 2026 | Viewed by 52 | Submission Open
Keywords: extracorporeal membrane oxygenation (ECMO); extracorporeal life support (ECLS); extracorporeal cardiopulmonary resuscitation (eCPR); extracorporeal gas exchange; extracorporeal circulation; acute respiratory distress syndrome (ARDS); cardiogenic shock (CS)
(This special issue belongs to the Section Intensive Care)
Diagnosis and Clinical Management in Hematologic Oncology
edited by Sunil Lakhwani and José María Raya-Sánchez
submission deadline 20 Aug 2026 | Viewed by 51 | Submission Open
Keywords: hematologic malignancies; lymphoma; multiple myeloma; acute leukemia; myeloproliferative neoplasms; molecular diagnostics; targeted therapy; immunotherapy; prognostic biomarkers; clinical management
(This special issue belongs to the Section Hematology)
Updates on Embolization and Embolotherapy for Benign Prostatic Hyperplasia and Men’s Health
edited by Sandeep L. Bagla, Ari J. Isaacson and Abin Sajan
submission deadline 20 Aug 2026 | Viewed by 49 | Submission Open
Keywords: benign prostatic hyperplasia; prostatic artery embolization; men’ s health; lower urinary tract symptoms; embolization therapy; radiation safety; prostate cancer and radiotherapy
(This special issue belongs to the Section Nephrology & Urology)
Pharmacological Pain Management Advances
edited by Michael A. Ueberall
submission deadline 20 Aug 2026 | Viewed by 47 | Submission Open
Keywords: pain management; drug therapy; analgesics; co-analgesics; drug safety and drug interactions; real-world evidence
(This special issue belongs to the Section Anesthesiology)
Advances in Trauma and Orthopedic Surgery: 3rd Edition submission deadline 20 Aug 2026 | Viewed by 47 | Submission Open
Keywords: trauma; fracture; fracture fixation; osteosynthesis; biomechanics; bone; approach; nonunion; joint replacement; outcome
(This special issue belongs to the Section Orthopedics)
New Perspectives and Innovations in Critical Illness submission deadline 20 Aug 2026 | Viewed by 47 | Submission Open
Keywords: critical illness; intensive care; ECMO; hemodynamic management; shock physiology; cardiovascular support
(This special issue belongs to the Section Intensive Care)
Physiotherapy: Multidisciplinary Interventions and Digital Health submission deadline 20 Aug 2026 | Viewed by 46 | Submission Open
Keywords: physiotherapy; rehabilitation; physical medicine; digital health; telemedicine; virtual reality; augmented reality; artifi-cial intelligence; robotic rehabilitation; wearable sensors; VR for educative goals; musculoskeletal; neurological; cognitive; pediatric; pulmonary; cardiac and gyneco-obstetric disorders; fibromyalgia syndrome; chronic pain; older adults
(This special issue belongs to the Section Clinical Rehabilitation)
Recent Clinical Perspectives on Chronic Kidney Disease
edited by Luca Visconti
submission deadline 20 Aug 2026 | Viewed by 45 | Submission Open
Keywords: chronic kidney disease; nephrology; hemodialysis; renal impairment; renal replacement therapy; new therapeutic approaches in CKD; clinical trials; renal complications
(This special issue belongs to the Section Nephrology & Urology)
Cardiovascular Prevention and Epidemiology: Innovations and Insights Bridging Research and Practice for Effective Risk Reduction
edited by and Maria Maiello
submission deadline 20 Aug 2026 | Viewed by 45 | Submission Open
Keywords: cardiovascular prevention; risk reduction; epidemiology; innovations; risk stratification; population health
(This special issue belongs to the Section Cardiovascular Medicine)
Heart Failure and Transplant Cardiology: Latest Advances and Prospects
edited by Monika Budnik
submission deadline 20 Aug 2026 | Viewed by 44 | Submission Open
Keywords: heart failure; heart transplantation; bridge to transplant; mechanical circulatory support; cardiomyopathies
(This special issue belongs to the Section Cardiology)
Endocrine Surgery: Current Treatment and Future Options
edited by Pietro Princi and
submission deadline 20 Aug 2026 | Viewed by 44 | Submission Open
Keywords: endocrine surgery; thyroid surgery; parathyroid surgery; adrenal gland surgery; neuroendocrine neoplasms; thyroid cancer; thyroid cancer treatment; surgical endocrinology; robotic endocrine surgery; laparoscopic adrenalectomy; ret-roperitoneoscopic adrenalectomy; parathyroidectomy; benign thyroid disease; thyroid ablation
(This special issue belongs to the Section General Surgery)
Clinical Advances in Adult Deformities and Spinal Disorders: Surgical Treatment and Pre- and Post-Operative Re-Habilitation
edited by
submission deadline 20 Aug 2026 | Viewed by 44 | Submission Open
Keywords: scoliosis; spine; kyphosis; degenerative spine; spine surgery
(This special issue belongs to the Section Orthopedics)
Advances in Pulmonary Embolism Therapeutic
edited by
submission deadline 20 Aug 2026 | Viewed by 43 | Submission Open
Keywords: acute pulmonary embolism; chronic pulmonary embolism; chronic thromboembolic disease; chronic thromboem-bolic pulmonary hypertension; catheter-directed therapy; pulmonary endarterectomy; balloon pulmonary angio-plasty
(This special issue belongs to the Section Vascular Medicine)
Revisional and Conversion Bariatric Surgery: Safety and Outcomes
edited by Jerry Dang
submission deadline 20 Aug 2026 | Viewed by 43 | Submission Open
Keywords: revisional bariatric surgery; conversion surgery; weight recurrence; surgical outcomes; sleeve gastrectomy; roux-en-y gastric bypass; post-bariatric complications; GERD
(This special issue belongs to the Section General Surgery)
Clinics and Management of Allergic and Inflammatory Skin Disorders submission deadline 20 Aug 2026 | Viewed by 42 | Submission Open
Keywords: allergic dermatoses; chronic inflammatory dermatoses; atopic dermatosis; contact dermatitis; chronic urticria; rosacea; psoriasis; hidradenitis suppurativa; diagnosis; comorbidities; management
(This special issue belongs to the Section Dermatology)
Contemporary Coronary Intervention: Innovation, Evidence, and Patient-Centred Outcomes
edited by Kevin Liou
submission deadline 20 Aug 2026 | Viewed by 40 | Submission Open
Keywords: percutaneous coronary interventions; coronary imaging; coronary physiology; precision medicine; CHIP PCI; stent-less technologies; clinical outcomes; pharmacotherapy in PCI; biomarkers; artificial intelligence in PCI; sustainability in PCI
(This special issue belongs to the Section Cardiology)
Optimizing Blood Management in Perioperative Cardiac Care: A Multidisciplinary Approach
edited by
submission deadline 20 Aug 2026 | Viewed by 40 | Submission Open
Keywords: perioperative cardiac care; patient blood management; cardiac surgery; blood transfusion; transfusion thresholds; bleeding management; hemostatic therapy; anticoagulation management; point‑of‑care coagulation testing
(This special issue belongs to the Section Cardiology)
Future-Proof Care for Patients with Kidney Stones
edited by and Oliver Wiseman
submission deadline 20 Aug 2026 | Viewed by 39 | Submission Open
Keywords: effectiveness; resilience; prevention; care pathways; urolithiasis; kidney stones; PCNL; URS; ESWL; quality of life
(This special issue belongs to the Section Nephrology & Urology)
Managing Chronic Kidney Disease: Current Practices and Future Perspectives
edited by Maria L. Gonzalez-Suarez
submission deadline 20 Aug 2026 | Viewed by 38 | Submission Open
Keywords: chronic kidney disease; diabetic kidney disease; kidney failure; guideline-directed therapies; SLGT 2 inhibitors; GLP1 receptor agonists
(This special issue belongs to the Section Nephrology & Urology)
Integrated Ozone Therapy and Physical Rehabilitation for Musculoskeletal Disorders: A Comprehensive Approach submission deadline 20 Aug 2026 | Viewed by 38 | Submission Open
Keywords: ozone therapy; physical rehabilitation; musculoskeletal disorders; integrative medicine; rehabilitation therapy; regenerative medicine; clinical outcomes
(This special issue belongs to the Section Clinical Rehabilitation)
Clinical Applications and Surgical Integration of Advanced Ophthalmic Imaging
edited by Katarzyna Nowomiejska
submission deadline 20 Aug 2026 | Viewed by 34 | Submission Open
Keywords: ophthalmic imaging; retina; intraoperative OCT; personalized treatment; clinical applications
(This special issue belongs to the Section Ophthalmology)
Targeting Extravalvular Burden Associated with Valvular Heart Disease
edited by
submission deadline 20 Aug 2026 | Viewed by 33 | Submission Open
Keywords: valvular heart disease; systemic disorder; extravalvular burden; valve dysfunction; valve intervention; multimodality imaging
(This special issue belongs to the Section Cardiology)
From Histology to Clinical Immunology: Integrated Diagnosis in Oral and Maxillofacial Diseases
edited by Fabiana Nicita
submission deadline 20 Aug 2026 | Viewed by 24 | Submission Open
Keywords: clinical immunology; histology; immunopathology; immune-mediated oral disease; biomarkers
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Spine Surgery and Postoperative Management
edited by Mitchell K. Ng
submission deadline 20 Aug 2026 | Viewed by 21 | Submission Open
Keywords: spine surgery; perioperative care; enhanced recovery after surgery (ERAS); multimodal analgesia; opioid-sparing strategies; neuromonitoring; perioperative optimization
(This special issue belongs to the Section Orthopedics)
Spine Surgery: Clinical Advances and Future Directions—2nd Edition
edited by Eun-Sang Kim and
submission deadline 20 Aug 2026 | Viewed by 20 | Submission Open
Keywords: spine surgery; back pain; endoscopic spine surgery; cage implantation; neck pain
(This special issue belongs to the Section Clinical Neurology)
Carotid Artery Disease: Current Hurdles and Future Perspectives
edited by Andrej Udelnow
submission deadline 20 Aug 2026 | Viewed by 16 | Submission Open
Keywords: carotid artery disease; carotid stenosis; endovascular technique; CEUS; elastography; high resolution CTA; atherosclerotic diseases; inflammatory diseases
(This special issue belongs to the Section Vascular Medicine)
Current Trends and Progress in Eating Disorders and Obesity Management
edited by Davide Gravina, and
submission deadline 20 Aug 2026 | Viewed by 15 | Submission Open
Keywords: eating disorders; anorexia nervosa; bulimia nervosa; binge-eating disorder; ARFID; obesity; neuromodulation; bi-omarkers; gut microbiome; pharmacological interventions; incretin receptor agonists; GLP-1; metreleptin; psyche-delics
(This special issue belongs to the Section Mental Health)
Clinical Update on Prenatal Diagnosis and Maternal Fetal Medicine
edited by Gianluca Campobasso
submission deadline 20 Aug 2026 | Viewed by 15 | Submission Open
Keywords: fetal medicine; malformations; obstetric; prenatal diagnosis; artificial intelligence
(This special issue belongs to the Section Obstetrics & Gynecology)
Musculoskeletal Pain: Clinical Management Updates submission deadline 20 Aug 2026 | Viewed by 12 | Submission Open
Keywords: musculoskeletal pain; chronic pain; gait assessment; musculoskeletal disorders; patellofemoral pain
(This special issue belongs to the Section Clinical Rehabilitation)
Clinical Advance and Perspective in Neuro-Oncology
edited by Mariko Sato and
submission deadline 20 Aug 2026 | Viewed by 5 | Submission Open
Keywords: neuro-oncology; diagnosis; treatment; minimally invasive surgery; skull base surgery; brain tumor; radiosurgery; neuro endoscopy
(This special issue belongs to the Section Clinical Neurology)
Clinical Advances in Diagnosis and Treatment of Metastatic Spinal Tumor
edited by
submission deadline 20 Aug 2026 | Viewed by 5 | Submission Open
Keywords: metastatic spinal tumors; spine surgery; bone metastasis; imaging diagnosis; minimally invasive surgery; decompres-sion surgery; fixation surgery; emergency surgery; prognosis prediction; elderly patients; nutrition; mental health
(This special issue belongs to the Section Oncology)
Novel Approaches in Obsessive–Compulsive and Related Spectrum Disorders
edited by and Andrea D. Guastello
submission deadline 20 Aug 2026 | Viewed by 4 | Submission Open
Keywords: OCD; misophonia; hoarding; tic disorders; assessment; treatment
(This special issue belongs to the Section Mental Health)
Hepatobiliary–Pancreatic Surgery in the Era of Interventional Radiology
edited by
submission deadline 20 Aug 2026 | Viewed by 3 | Submission Open
Keywords: hepato-biliary– pancreatic surgery; interventional radiology; percutaneous biliary drainage; percutaneous pancre-atic drainage; portal vein embolization; tumor ablation; minimally invasive surgery; cryoablation; thermoablation
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Clinical Outcomes of Glaucoma Surgery: Visual Acuity, Effectiveness and Quality of Life submission deadline 21 Aug 2026 | Viewed by 72 | Submission Open
Keywords: glaucoma surgery; visual acuity; intraocular pressure; surgical outcomes; trabeculectomy; microinvasive glaucoma surgery; postoperative complications; functional vision
(This special issue belongs to the Section Ophthalmology)
Advancements in Cardiomyopathies: Diagnosis, Treatment and Management—2nd Edition submission deadline 24 Aug 2026 | 1 articles | Viewed by 189 | Submission Open
Keywords: cardiomyopathies; multimodality imaging; cardiac magnetic resonance; genetic testing; cardiogenetics; genetic cardiovascular disease; rare cardiovascular diseases; risk stratification; genotype– phenotype correlations; rare variant interpretation; arrhythmias
(This special issue belongs to the Section Cardiology)
Knee Arthroplasty: Recent Advances and Future Challenges
edited by Matteo Marullo
submission deadline 25 Aug 2026 | Viewed by 91 | Submission Open
Keywords: knee arthroplasty; implant design; robotic surgery; revision surgery; biomechanics; clinical outcomes; perioperative care; fast-track surgery; digital orthopedics; partial knee replacement
(This special issue belongs to the Section Orthopedics)
Current and Emerging Strategies in Ischemic Stroke: Diagnosis, Treatment, and Prevention submission deadline 25 Aug 2026 | Viewed by 84 | Submission Open
Keywords: diagnosis; digital medicine; epidemiology; ischemic stroke; machine learning; neurorehabilitation; prevention; stroke imaging; treatment
(This special issue belongs to the Section Clinical Neurology)
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