Inflammatory Diseases and Viral Immune Modulating Protein Therapeutics

Dear Colleagues,

Viruses have developed highly effective immune modulating proteins through millions of years of evolution. These immune modulating proteins allow viruses to avoid and/or actively combat inflammatory and immune responses from the infected host that are designed to block viral invasion and proliferation. These highly evolved and efficient virus-derived immune modulating mechanisms are often very potent, working at low concentrations in the picomolar range and targeting key immune pathways. In prior work, we and other investigators have examined these unique proteins as a new source for biologics, protein and peptide therapeutics. With this series of papers, our intent is to illustrate and to explore the potential of virus-derived immune modulating proteins to provide new and highly effective therapeutic approaches to alter immune responses in disease.

Prof. Dr. Alexandra Lucas
Guest Editor

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