Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
5.4
3.9
Journals
JCM
Special Issues
Hyponatremia: Challenges and Solutions
share announcement

Hyponatremia: Challenges and Solutions

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Endocrinology & Metabolism".

Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 18098

Special Issue Editor

Dr. Theodosios D. Filippatos

E-Mail Website
Guest Editor
Metabolic Diseases Research Unit, Internal Medicine Laboratory, School of Medicine, University of Crete, Voutes, Heraklion, Greece
Interests: diabetes; obesity; vascular disease prevention; electrolyte disorders

Special Issue Information

Dear Colleagues,

Hyponatremia is the most common electrolyte disorder and is related with increased morbidity and mortality. The appropriate diagnosis of the causative factor(s) is of paramount importance for the proper management of hyponatremia and avoidance of treatment pitfalls. Certain populations, such as the elderly, present certain challenges in the evaluation and treatment of hyponatremia. A number of pharmacological options is available for the treatment of reduced serum sodium levels. In this regard, vaptans are now available in many countries for the treatment of non-hypovolemic hyponatremia. Clinicians should be cautious during treatment of hyponatremia, as an overly rapid increase in serum sodium levels may lead to devastating consequences such as osmotic demyelination syndrome.

In this Special Issue, we invite researchers and clinicians to submit their works, including original clinical research studies, meta-analyses, and systematic reviews, which will provide additional knowledge for hyponatremia prevention, evaluation and treatment.

Dr. Theodosios D. Filippatos
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hyponatremia
  • electrolyte disorder
  • reduced serum sodium levels
  • vaptans

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

11 pages, 686 KiB  
Article
Increased Mortality in Elderly Patients Admitted with Hyponatremia: A Prospective Cohort Study
by Petros Ioannou, Symeon Panagiotakis, Emmanouela Tsagkaraki, Constantinos Tsioutis, Konstantinos Fragkiadakis, Achilleas Gikas and Theodosios D. Filippatos
J. Clin. Med. 2021, 10(14), 3059; https://doi.org/10.3390/jcm10143059 - 10 Jul 2021
Cited by 7 | Viewed by 4115
Abstract
Hyponatremia is the most common electrolyte disorder, commonly affecting older hospitalized individuals; however, the literature is not clear regarding its effect on mortality. The aim of this 2-year observational prospective cohort study was to evaluate the mortality and re-admission rates, the clinical and [...] Read more.
Hyponatremia is the most common electrolyte disorder, commonly affecting older hospitalized individuals; however, the literature is not clear regarding its effect on mortality. The aim of this 2-year observational prospective cohort study was to evaluate the mortality and re-admission rates, the clinical and laboratory characteristics and the causes of hyponatremia in patients older than 65 years admitted with a corrected serum sodium of 130 mEq/L or less in an internal medicine ward of a tertiary Greek university hospital. During the observation period, 138 patients (mean age 80.5 years, 36.2% male) fulfilled the inclusion criteria and were prospectively followed for 1 year after admission. Symptoms of hyponatremia were present in 59.4% of patients. Hypovolemia was the main sole cause of hyponatremia, but in about one third of patients, hyponatremia was multifactorial. Only a low proportion of patients (12.3%) fulfilled the criteria of the syndrome of inappropriate antidiuresis (SIAD) at admission according to the current guidelines. The re-admission rates at 3- and 12-months following discharge was 34.2% and 51.8%, respectively. Mortality during hospitalization was 17.4% and was higher compared to non-hyponatremic admitted older patients, while the total mortality at 1 year after admission was 28.3%, indicating that hyponatremia at admission is a marker of significant mortality during and after hospitalization in elderly patients. Full article
(This article belongs to the Special Issue Hyponatremia: Challenges and Solutions)
►▼ Show Figures

Figure 1

9 pages, 758 KiB  
Article
The Effect of the Dose of Isotonic Saline on the Correction of Serum Sodium in the Treatment of Hypovolemic Hyponatremia
by Jorge Gabriel Ruiz-Sánchez, Diego Meneses, Cristina Álvarez-Escolá, Martin Cuesta, Alfonso Luis Calle-Pascual and Isabelle Runkle
J. Clin. Med. 2020, 9(11), 3567; https://doi.org/10.3390/jcm9113567 - 05 Nov 2020
Cited by 6 | Viewed by 2540
Abstract
Background: Overcorrection of serum sodium (SNa) during therapy of hyponatremia can result in osmotic demyelination syndrome. Our aim was to determine the relationship between the isotonic saline solution dose (ISSD) administered and the 24-h SNa increase (24SNa) in patients with hypovolemic hyponatremia (HH). [...] Read more.
Background: Overcorrection of serum sodium (SNa) during therapy of hyponatremia can result in osmotic demyelination syndrome. Our aim was to determine the relationship between the isotonic saline solution dose (ISSD) administered and the 24-h SNa increase (24SNa) in patients with hypovolemic hyponatremia (HH). Methods: Retrospective study of HH patients treated with ISS in a tertiary hospital of Madrid, Spain, between 1 January–30 May 2019. The 24-h ISSD received and corresponding 24SNa were calculated. The latter was classified as 3 groups: ≥8 mmol/L, ≥6 mmol/L, or <4 mmol/L. Multivariate regression analyses were performed and ROC curves calculated to study the relationship between ISSD and 24SNa. Results: Thirty patients were included, age 72 years (60–80), 50% were women. 24SNa was ≥8 mmol/L/24 h in 33%, ≥6 mmol/L/24 h in 50%, and <4 mmol/L/24 h in 30%. Median ISSD in each group was: 32 mL/kg/24 h (29–37), 31 mL/kg/24 h (25–33), and 20 mL/kg/24 h (14–22), respectively. An ISSD ≥ 30 mL/kg/24 h had an odds ratio (OR) of 16 (95% CI: 2.5–95.1; p = 0.004) for a 24SNa ≥8 mmol/L, with a sensitivity and specificity of 80%. Conclusions: The 24SNa depends on ISSD. An ISSD between 23–30 mL/kg/24 h seems to be safe and effective. Full article
(This article belongs to the Special Issue Hyponatremia: Challenges and Solutions)
►▼ Show Figures

Figure 1

Review

Jump to: Research

24 pages, 1303 KiB  
Review
Hyponatremia in Patients with Hematologic Diseases
by Epameinondas Koumpis, Matilda Florentin, Eleftheria Hatzimichael and George Liamis
J. Clin. Med. 2020, 9(11), 3721; https://doi.org/10.3390/jcm9113721 - 19 Nov 2020
Cited by 10 | Viewed by 10782
Abstract
Hyponatremia is the most common electrolyte disorder in clinical practice and is associated with increased morbidity and mortality. It is frequently encountered in hematologic patients with either benign or malignant diseases. Several underlying mechanisms, such as hypovolemia, infections, toxins, renal, endocrine, cardiac, and [...] Read more.
Hyponatremia is the most common electrolyte disorder in clinical practice and is associated with increased morbidity and mortality. It is frequently encountered in hematologic patients with either benign or malignant diseases. Several underlying mechanisms, such as hypovolemia, infections, toxins, renal, endocrine, cardiac, and liver disorders, as well as the use of certain drugs appear to be involved in the development or the persistence of hyponatremia. This review describes the pathophysiology of hyponatremia and discusses thoroughly the contributing factors and mechanisms that may be encountered specifically in patients with hematologic disorders. The involvement of the syndrome of inappropriate antidiuretic hormone (SIADH) secretion and renal salt wasting syndrome (RSWS) in the development of hyponatremia in such patients, as well as their differential diagnosis and management, are also presented. Furthermore, the distinction between true hyponatremia and pseudohyponatremia is explained. Finally, a practical algorithm for the evaluation of hyponatremia in hematologic patients, as well as the principles of hyponatremia management, are included in this review. Full article
(This article belongs to the Special Issue Hyponatremia: Challenges and Solutions)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop