Key Advances in the Treatment of the Critically Ill: 3rd Edition
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Intensive Care".
Deadline for manuscript submissions: 15 December 2025 | Viewed by 71
Special Issue Editor
Interests: cardiac arrest; postcardiac arrest syndrome; mechanical ventilation; ethics of end-of-life decisions; hospital-acquired infections; airway management
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
It is my pleasure to invite you to contribute to the Special Issue entitled “Key Advances in the Treatment of the Critically Ill: 3rd Edition”. This is a new volume; for more details about the former two volumes, please visit the following links:
https://www.mdpi.com/journal/jcm/special_issues/critical_ill
https://www.mdpi.com/journal/jcm/special_issues/WC1XDY26S3
Intensive Care Medicine (ICM) fundamentally concerns the management of organ system failures arising from a wide array of acute and severe conditions, often compounded by coexisting comorbidities. Survival outcomes without severe disability vary dramatically—from less than 10% to more than 90%. Over several decades of rigorous randomized controlled trials, only a handful of key therapeutic interventions have been shown to directly and significantly improve patient outcomes. Landmark interventions include lung-protective mechanical ventilation and prone positioning in acute respiratory distress syndrome (ARDS); targeted temperature management, amiodarone, and the combination of vasopressin–steroids–epinephrine, in addition to extracorporeal cardiopulmonary resuscitation (ECPR) in selected cases of cardiac arrest; tranexamic acid in trauma (including head injury); and the prompt administration of antibiotics in sepsis and septic shock. Moreover, the systematic application of physiologically and pharmacologically sound intervention bundles—such as those outlined in current guidelines for sepsis, ARDS, and postcardiac arrest care—has played a pivotal role in enhancing patient outcomes over recent decades.
In recent years, the field has rapidly evolved through the development and application of novel therapeutic modalities. Advanced interventions—including immunomodulatory therapies, receptor-targeting proteins, adsorbent-based blood purification technologies, and increasingly sophisticated organ support systems—are redefining clinical practice in ICM. For example, extracorporeal membrane oxygenation (ECMO) has emerged as a promising option for select patients with refractory respiratory or circulatory failure, reflecting a broader trend toward personalized, technology-driven critical care. These innovations not only broaden the therapeutic arsenal but also hold the potential to substantially alter traditional treatment paradigms.
The present Special Issue invites submissions of reviews and original articles addressing any of the aforementioned topics related to ICM.
Prof. Dr. Spyros D. Mentzelopoulos
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- respiration
- artificial ventilation
- prone positioning
- respiratory distress syndrome
- respiratory insufficiency
- cardiac arrest
- induced hypothermia
- amiodarone
- vasopressin
- steroids
- epinephrine
- trauma
- injuries
- tranexamic acid
- sepsis
- antibiotics
- extracorporeal membrane oxygenation
- extracorporeal CPR
- blood purification
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