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Clinical Advances in Spine Disorders
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Clinical Advances in Spine Disorders

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Neurology".

Deadline for manuscript submissions: 30 May 2025 | Viewed by 3254

Special Issue Editors

Dr. Sokol Trungu

E-Mail Website
Guest Editor
Neurosurgery Unit, Cardinale G. Panico Hospital, 73039 Tricase, Italy
Interests: spinal surgery; spinal cord injury; spine surgery; microneurosurgery; neuro-oncology; glioma; traumatic brain injury; neuroanatomy; brain tumors; intervertebral disk degeneration
Dr. Luca Ricciardi

E-Mail Website
Guest Editor
Department of Neuroscience, Mental Health and Sense Organs (NESMOS), Sant’Andrea Hospital, Sapienza University of Rome, 00189 Rome, Italy
Interests: spine surgery; spinal surgery; spinal cord injury; microneurosurgery; neuroanatomy; brain injury; traumatic brain injury; glioma; spine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Clinical advances and surgical techniques for the treatment of spine disorders have been effective in minimizing invasiveness and reducing complications. However, there is always a need for improvements in patient outcomes with new understandings of the latest developments in lumbar spine surgery. In this Special Issue "Clinical Advances in Spine Disorders" of the Journal of Clinical Medicine, we are interested in providing a comprehensive overview of the latest evolution of emerging conservative treatment and surgical techniques, with a focus on minimally invasive surgery and the use of robotics and navigation systems.

We welcome authors to submit their papers in this Special Issue focusing on the newest clinical advances in spine disorders. We hope that it will stimulate interest regarding the unsolved challenges in spine surgery.

Dr. Sokol Trungu
Dr. Luca Ricciardi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • spine disorders
  • lumbar spine surgery
  • minimally invasive surgery
  • spine surgery
  • microneurosurgery

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

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Research

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8 pages, 409 KiB  
Article
Influence of a Lordotic Cage Profile on Global and Segmental Lordosis in the Context of Lumbar TLIF Surgeries: A Retrospective Radiological Analysis
by Steffen Schulz, Peter Fennema, Ali Darwich, Frederic Bludau and Marcus Rickert
J. Clin. Med. 2024, 13(23), 7012; https://doi.org/10.3390/jcm13237012 - 21 Nov 2024
Viewed by 616
Abstract
Background/Objectives: Cage implantation decompresses neural elements, stabilizes segments, and promotes fusion, with sagittal balance influenced by cage size, geometry, and position. This retrospective study compared the effects of lumbar interbody cages with 10° and 15° lordotic angles on global and segmental lordosis in [...] Read more.
Background/Objectives: Cage implantation decompresses neural elements, stabilizes segments, and promotes fusion, with sagittal balance influenced by cage size, geometry, and position. This retrospective study compared the effects of lumbar interbody cages with 10° and 15° lordotic angles on global and segmental lordosis in patients undergoing transforaminal lumbar interbody fusion (TLIF). Methods: Data from 215 patients who underwent 259 TLIF procedures between 2018 and 2022 were analyzed. All the surgeries were performed by a single senior orthopedic spine surgeon, and cages were selected by the surgeon based on patients’ clinical and anatomical factors. Radiographic assessments included measurements of global and segmental lordosis. Results: Patients who received 15° cages demonstrated significantly greater segmental lordosis compared to those who received 10° cages in both bisegmental and monosegmental procedures (p < 0.001). While the global lordosis in the 10°-cage group remained unchanged postoperatively (p = 0.687), bisegmental procedures showed a small but statistically significant increase (p = 0.035). Moreover, global lordosis did not significantly differ between the 10°- and 15°-cage groups. Conclusions: Cage geometry significantly influenced segmental lordosis, with 15° cages achieving overall more superior radiographic results compared to 10° cages. However, global lordosis was unaffected by cage angle, thereby highlighting the multifaceted nature of factors that influence overall spinal alignment. These findings provide valuable insights into lumbar spine surgery, thus emphasizing the need for comprehensive preoperative planning and consideration of individual patient characteristics. Full article
(This article belongs to the Special Issue Clinical Advances in Spine Disorders)
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Review

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21 pages, 20581 KiB  
Review
Postoperative Infection After Esophageal Injury in Anterior Cervical Spine Surgery: A Comprehensive Review of Diagnosis, Management, and Outcomes
by Chae-Gwan Kong and Jong-Beom Park
J. Clin. Med. 2025, 14(9), 3244; https://doi.org/10.3390/jcm14093244 - 7 May 2025
Viewed by 205
Abstract
Postoperative infection following anterior cervical spine surgery, particularly when complicated by esophageal injury, is a rare but serious condition associated with significant morbidity and mortality. This review elucidates the complex interplay between postoperative infection and esophageal injury. We systematically analyzed studies from 2000 [...] Read more.
Postoperative infection following anterior cervical spine surgery, particularly when complicated by esophageal injury, is a rare but serious condition associated with significant morbidity and mortality. This review elucidates the complex interplay between postoperative infection and esophageal injury. We systematically analyzed studies from 2000 to 2025 using PubMed, Scopus, and Web of Science, focusing on infection, esophageal injury, surgical outcomes, and management strategies, with emphasis on recent advances in diagnostics, surgical techniques, and postoperative care. Our findings highlight the multifactorial nature of these complications and the critical role of early recognition, accurate diagnosis, and timely management. Imaging modalities such as CT, MRI, and contrast esophagography, along with flexible esophagoscopy, are indispensable in assessing injury and infection extent. Effective management requires a multidisciplinary approach integrating broad-spectrum antibiotics, surgical debridement, vascularized flap reinforcement, negative pressure wound therapy, and antibiotic-loaded cement beads. Meticulous postoperative care with prolonged antibiotics, nutritional support, and imaging follow-up is vital for optimizing outcomes. Innovative approaches, including vascularized muscle flaps and hyperbaric oxygen therapy, show promise in enhancing healing and reducing infections. Our review underscores the need for future meta-analyses to strengthen evidence and refine protocols. As surgical techniques evolve, so too must our diagnostic, surgical, and postoperative strategies to minimize complications and improve patient outcomes. Full article
(This article belongs to the Special Issue Clinical Advances in Spine Disorders)
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Other

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28 pages, 914 KiB  
Systematic Review
Prognostic Factors in Patients Undergoing Physiotherapy for Chronic Low Back Pain: A Level I Systematic Review
by Alice Baroncini, Nicola Maffulli, Marco Pilone, Gennaro Pipino, Michael Kurt Memminger, Gaetano Pappalardo and Filippo Migliorini
J. Clin. Med. 2024, 13(22), 6864; https://doi.org/10.3390/jcm13226864 - 14 Nov 2024
Cited by 5 | Viewed by 1815
Abstract
Background: Low back pain is common. For patients with mechanic or non-specific chronic LBP (cLBP), the current guidelines suggest conservative, nonpharmacologic treatment as a first-line treatment. Among the available strategies, physiotherapy represents a common option offered to patients presenting with cLBP. The [...] Read more.
Background: Low back pain is common. For patients with mechanic or non-specific chronic LBP (cLBP), the current guidelines suggest conservative, nonpharmacologic treatment as a first-line treatment. Among the available strategies, physiotherapy represents a common option offered to patients presenting with cLBP. The present systematic review investigates the prognostic factors of patients with mechanic or non-specific cLBP undergoing physiotherapy. Methods: In September 2024, the following databases were accessed: PubMed, Web of Science, Google Scholar, and Embase. All the randomised controlled trials (RCTs) which evaluated the efficacy of a physiotherapy programme in patients with LBP were accessed. All studies evaluating non-specific or mechanical LBP were included. Data concerning the following PROMs were collected: the pain scale, Roland Morris Disability Questionnaire (RMQ), and Oswestry Disability Index (ODI). A multiple linear model regression analysis was conducted using the Pearson Product–Moment Correlation Coefficient. Results: Data from 2773 patients were retrieved. The mean length of symptoms before the treatment was 61.2 months. Conclusions: Age and BMI might exert a limited influence on the outcomes of the physiotherapeutic management of cLBP. Pain and disability at baseline might represent important predictors of health-related quality of life at the six-month follow-up. Further studies on a larger population with a longer follow-up are required to validate these results. Full article
(This article belongs to the Special Issue Clinical Advances in Spine Disorders)
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