Molecular Control of Development and Function of the Cardiac Conduction System

Dear Colleagues,

In recent years our understanding of the molecular basis of cardiac conduction system (CCS) development has significantly improved. The transcriptional and signalling networks controlling CCS development have been unravelled to a significant extent. The origin and function of different cell lineages contributing to the CCS have been studied in model organisms. A comparative analysis of the CCS in different vertebrate species has helped to recognize the different building blocks and define their evolutionary origins. Until recently, the cardiac autonomous nervous system (CANS) was considered just a dispensable source for modulating the heart rate. However, recent research suggests that the CANS has a much more complex role and is for example also responsible for sinus node dysfunction, modulating cardiac hypertrophy and being essential for cardiac regeneration. We are still learning about the mechanisms of cardiac pacemaking, its modulation by the CANS and the role of cAMP compartmentation in pacemaker cells. The molecular basis of sinus node dysfunction. Our understanding of the molecular basis of CCS disfunction has improved. Likewise, the prospects of developing biological pacemakers is at the horizon. The goal of this issue is to stimulate new investigations into CCS development and its pathological and clinical implications. We invite you to consider contributing a research paper or review article on any aspect related to the topic of this Special Issue. This may be an opportunity for doctoral and post-doctoral trainees to contribute to a review articles and showcase their areas of expertise.

Prof. Dr. Takashi Mikawa
Prof. Dr. Thomas Brand
Guest Editors

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